EJNMMI Radiopharmacy and Chemistry, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 4, 2024

Abstract Background Radiation nanomedicines are nanoparticles labeled with radionuclides that emit α- or β-particles Auger electrons for cancer treatment. We describe here our 15 years scientific journey studying locally-administered radiation further present a view of the nanomedicine landscape by reviewing research reported other groups. Main body Gold were studied initially radiosensitization breast to X-radiation therapy. These 111 In assess their biodistribution after intratumoural vs. intravenous injection. Intravenous injection was limited high liver and spleen uptake low tumour uptake, while provided but normal tissue uptake. Further, [ In]In-labeled gold modified trastuzumab injected iintratumourally exhibited strong growth inhibition in mice subcutaneous HER2-positive human xenografts. subsequent studies, achieved without toxicity xenografts intratumourally β-particle emitting 177 Lu panitumumab specifically bind EGFR HER2, respectively. A nanoparticle depot (nanodepot) designed incorporate deliver radiolabeled tumours using brachytherapy needle insertion techniques. Treatment s.c. 4T1 murine mammary carcinoma nanodepot incorporating 90 Y]Y-labeled inserted into one arrested caused an abscopal growth-inhibitory effect on distant second tumour. Convection-enhanced delivery Lu]Lu-AuNPs orthotopic glioblastoma multiforme (GBM) toxicity. Other groups have explored treatment preclinical animal xenograft models nanoparticles, liposomes, block copolymer micelles, dendrimers, carbon nanotubes, cellulose nanocrystals iron oxide nanoparticles. ( In, 99m Tc, 125 I, 103 Pd, 193m Pt, 195m Pt), Lu, 186 Re, 188 Y, 198 Au, 131 I) α-particles 225 Ac, 213 Bi, 212 Pb, 211 At, 223 Ra). studies employed convection enhanced delivery. Local administration these most effective minimized Conclusions shown great promise treating studies. avoids sequestration is tumours, minimizing

Language: Английский