Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

Inflammation and Regeneration, Journal Year: 2022, Volume and Issue: 42(1)

Published: Oct. 4, 2022

Abstract Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions. Nevertheless, ROS act as “double-edged swords” that have an unstable redox balance between production removal. A little raise of results in cell proliferation enhancement, survival, soft immune responses, while a high level could lead to damage consequently protein, nucleic acid, lipid damages finally death. play important role various pathological circumstances. On the contrary, can show selective toxicity is used against cancer cells pathogens. Photodynamic therapy (PDT) based on three components including photosensitizer (PS), oxygen, light. Upon excitation PS at specific wavelength, PDT process begins leads generation. produced during induce two different pathways. If produces control low ROS, it differentiation. However, excess by causes photo main mechanism treatment. This review summarizes functions living systems describes controllable special focus current ROS-generating therapeutic protocols regeneration wound healing.

Language: Английский

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Bacterial Biofilm in Chronic Wounds and Possible Therapeutic Approaches

Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 109 - 109

Published: Feb. 9, 2024

Wound repair and skin regeneration is a very complex orchestrated process that generally composed of four phases: hemostasis, inflammation, proliferation, remodeling. Each phase involves the activation different cells production various cytokines, chemokines, other inflammatory mediators affecting immune response. The microbial composition plays an important role in wound healing. Indeed, commensals are essential maintenance epidermal barrier function, regulation host response, protection from invading pathogenic microorganisms. Chronic wounds common considered major public health problem due to their difficult-to-treat features frequent association with challenging chronic infections. These infections can be tough manage ability some bacteria produce multicellular structures encapsulated into matrix called biofilms. bacterial species contained biofilm often different, as capability influence healing wounds. Biofilms are, fact, tolerant resistant antibiotics antiseptics, leading failure treatment. For these reasons, biofilms impede appropriate treatment and, consequently, prolong period. Hence, there urgent necessity deepen knowledge pathophysiology delayed develop more effective therapeutic approaches able restore tissue damage. This work covers wound-healing pathogenesis infected by biofilm-forming pathogens. An overview strategies counteract formation or destroy existing also provided.

Language: Английский

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Chitosan-Based Scaffolds Incorporated with Silver Nanoparticles for the Treatment of Infected Wounds

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 327 - 327

Published: Feb. 26, 2024

Bacterial infections are major problems in wound care due to their impact on the retarded process of healing, leading chronic wounds. Most presently utilized dressing products exhibit poor antimicrobial properties. Wound dressings formulated from chitosan have been reported be effective for treating infected wounds, resulting antibacterial properties chitosan. The chitosan-based can further enhanced by incorporating metallic nanoparticles into them, such as silver, zinc, titanium, etc. incorporation silver has widely explored design dressings. promotes accelerated wound-healing processes activity. healing these metal-based is via regulation re-epithelialization and inflammation without affecting viability normal cells. However, there few reports that evaluate infectious animal models prove efficacy. vivo toxicity still needs addressed, revealing need preclinical clinical trials. fabrication incorporated with not fully explored, especially wounds requiring immediate treatment. possible interactions between scaffolds result synergistic effects understood studied. This review provides a comprehensive report outcomes materials loaded managing

Language: Английский

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Innovative Approaches to Wound Healing: Insights into Interactive Dressings and Future Directions

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(33), P. 7977 - 8006

Published: Jan. 1, 2024

The objective of this review is to provide an up-to-date and all-encompassing account the recent advancements in domain interactive wound dressings. Considering gap between achieved desired clinical outcomes with currently available or under-study healing therapies, newer more specific options based on type phase are reviewed. Starting from comprehensive description process, a detailed classification dressings presented. Subsequently, we present elaborate significant discussion describing (unconventional) Latter includes biopolymer-based, bioactive-containing biosensor-based smart dressings, which discussed separate sections together their applications limitations. Moreover, (2-5 years) trials, patents unconventional marketed products, other information advanced care designs techniques discussed. future research direction highlighted, peptides, proteins, human amniotic membranes as potential Finally, conclude that field needs further development offers scope for integrating process technologies.

Language: Английский

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New Perspectives of Hydrogels in Chronic Wound Management

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 686 - 686

Published: Feb. 4, 2025

Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.

Language: Английский

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Copper‐Based Nanozymes: Potential Therapies for Infectious Wounds

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Bacterial infections are a significant obstacle to the healing of acute and chronic wounds, such as diabetic ulcers burn injuries. Traditional antibiotics primary treatment for bacterial infections, but they present issues antibiotic resistance, limited efficacy, potential side effects. This challenge leads exploration nanozymes alternative therapeutic agents. Nanozymes nanomaterials with enzyme‐like activities. Owing their low production costs, high stability, scalability, multifunctionality, have emerged prominent focus in antimicrobial research. Among various types nanozymes, metal‐based offer several benefits, including broad‐spectrum activity robust catalytic properties. Specifically, copper‐based (CuNZs) shown considerable promoting wound healing. They exhibit strong effects, reduce inflammation, enhance tissue regeneration, making them highly advantageous use care. review describes dual functions CuNZs combating infection facilitating repair. Recent advancements design synthesis CuNZs, evaluating promotion, biosafety both vitro vivo on basis core components, critically important.

Language: Английский

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Skin substitutes as treatment for chronic wounds: current and future directions

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Aug. 29, 2023

Chronic wounds such as diabetic foot ulcers and venous leg place a significant burden on the healthcare system in some cases, have 5-year mortality rates comparable to cancer. They negatively impact patients’ quality of life due pain, odor, decreased mobility, social isolation. Skin substitutes are an advanced therapy recommended for that fail show decrease size with standard care. The choice substitute used should be based evidence, which often differs wound etiology. There more than 75 skin currently available, number is rising. In this review, we discuss current management future directions chronic while providing review available randomized control trial data various substitutes.

Language: Английский

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Copper-Epigallocatechin Gallate Enhances Therapeutic Effects of 3D-Printed Dermal Scaffolds in Mitigating Diabetic Wound Scarring

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(32), P. 38230 - 38246

Published: Aug. 3, 2023

Morbid dermal templates, microangiopathy, and abnormal inflammation are the three most critical reasons for scarred healing high recurrence rate of diabetic wounds. In this present study, a combination methacrylated decellularized extracellular matrix (ECMMA, aka EM)-based hydrogel system loaded with copper-epigallocatechin gallate (Cu-EGCG) capsules is proposed to fabricate bio-printed scaffolds wound treatment. Copper ions act as bioactive element promoting angiogenesis, EGCG can inhibit on site. addition above activities, EM/Cu-EGCG (E/C) also provide optimized templates nutrient exchange space guiding orderly deposition remodeling ECM. vitro experiments have shown that E/C promote angiogenesis polarization macrophages M1 pro-inflammatory phenotype. full-thickness skin defect model rats, scaffold combined split-thickness graft transplantation alleviate pathological scarring via driving macrophage anti-inflammatory M2 These may be attributed scaffold-actuated expression angiogenesis-related genes in HIF-1α/vascular endothelial growth factor pathway decreased inflammation-related TNF-α/NF-κB/MMP9 pathway. The results study show could serve promising artificial analogue solving problems delayed reulceration

Language: Английский

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Flexible Organic Photovoltaic‐Powered Hydrogel Bioelectronic Dressing With Biomimetic Electrical Stimulation for Healing Infected Diabetic Wounds

Advanced Science, Journal Year: 2023, Volume and Issue: 11(10)

Published: Dec. 25, 2023

Abstract Electrical stimulation (ES) is proposed as a therapeutic solution for managing chronic wounds. However, its widespread clinical adoption limited by the requirement of additional extracorporeal devices to power ES‐based wound dressings. In this study, novel sandwich‐structured photovoltaic microcurrent hydrogel dressing (PMH dressing) designed treating diabetic This innovative comprises flexible organic (OPV) cells, micro–electro–mechanical systems (MEMS) electrode, and multifunctional serving an electrode–tissue interface. The PMH engineered administer ES, mimicking physiological injury current occurring naturally in wounds when exposed light; thus, facilitating healing. vitro experiments are performed validate dressing's exceptional biocompatibility robust antibacterial properties. vivo proteomic analysis reveal that significantly accelerates healing infected enhancing extracellular matrix regeneration, eliminating bacteria, regulating inflammatory responses, modulating vascular functions. Therefore, potent, versatile, effective care, paving way advancements wireless ES

Language: Английский

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Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 155 - 155

Published: Jan. 23, 2024

Wound infection due to bacterial invasion at the wound site is one of primary challenges associated with delayed healing. Microorganisms tend form biofilms that protect them from harm, leading their multidrug resistance. The alarming increase in antibiotic resistance poses a threat Hence, urgent need for novel dressing materials capable managing crucial expediting recovery. There considerable interest polymeric dressings embedded bioactive substances, such as metal-based nanoparticles, potential solutions treating microbially infected wounds. Metal-based nanoparticles have been widely used management wounds broad antimicrobial efficacy. This review focuses on polymer-based and loaded like silver, gold, magnesium oxide, or zinc oxide. When compared, oxide-loaded exhibited higher antibacterial activity against Gram-positive strains silver nanoparticle-loaded gram-negative strains. However, infused both displayed synergistic effect bacteria. Furthermore, these antibiofilm generation reactive oxygen species while accelerating closure vitro vivo.

Language: Английский

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