Androgens in cervical cancer: Their role in epidemiology and biology DOI Creative Commons

Yang Gu,

Qing Mu,

Dali Cheng

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(7), P. 110155 - 110155

Published: June 1, 2024

This comprehensive review delves into the significance of androgens in cervical cancer, examining both epidemiological evidence and underlying biological mechanisms. Cervical cancer ranks as fourth most prevalent among women globally, with disproportionately higher incidence mortality rates less developed regions where human papillomavirus (HPV) screening remains limited. Recent research highlights previously underexplored role cancer. Notably, tissues house androgen receptors, elevated levels endogenous have been linked to an increased risk Androgens exert their influence on development progression by impacting key cellular processes, including proliferation, apoptosis, differentiation, epithelial cell transformation. Furthermore, specific HPV subtypes may interact androgens, potentially modulating HPV-related degeneration In light these findings, it is evident that assume a crucial cancer's pathogenesis. Consequently, further investigations are warranted deepen our understanding intricate relationship between Such knowledge advancements can facilitate improved strategies for early prevention treatment especially limited access. underscores importance considering vital component multifaceted landscape etiology progression, ultimately contributing more effective clinical interventions.

Language: Английский

New Advances in Cervical Cancer: From Bench to Bedside DOI Open Access
Ottavia D’Oria, Giacomo Corrado, Antonio Simone Laganà

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(12), P. 7094 - 7094

Published: June 9, 2022

Cervical cancer is the most common gynecologic malignancy and fourth in women worldwide. Over last two decades, minimally invasive surgery (MIS) has emerged as mainstay surgical management of early-stage cervical cancer, bringing advantages such a lower operative morbidity shorter hospital stay compared to open surgery, while maintaining comparable oncologic outcomes numerous retrospective studies. Considering oncological patients, it mandatory assess safety this type surgery. Moreover, there are different future outlooks on therapy, based immunotherapy, target poly-ADP-ribose polymerases (PARP) inhibitors combination with each other, standard chemotherapy radiotherapy. The goal find an approach that personalized possible.

Language: Английский

Citations

73
Targeting the NRF2/KEAP1 pathway in cervical and endometrial cancers DOI
Giovanni Tossetta, Daniela Marzioni

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 941, P. 175503 - 175503

Published: Jan. 11, 2023

Language: Английский

Citations

67
Cancer Stem Cell Regulation as a Target of Therapeutic Intervention: Insights into Breast, Cervical and Lung Cancer DOI

S Kevat,

A. Mistry,

Naman Oza

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

1
Targeting Cancer Stemness Using Nanotechnology in a Holistic Approach: A Narrative Review DOI Creative Commons
Melinda-Ildiko Mitranovici, Laura Caravia,

Liviu Moraru

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 277 - 277

Published: Feb. 20, 2025

Increasing evidence shows that a very small population of cancer stem cells (CSCs) is responsible for recurrence, drug resistance, and metastasis. CSCs usually reside in hypoxic tumor regions are characterized by high tumorigenicity. Their inaccessible nature allows them to avoid the effects conventional treatments such as chemotherapy, radiotherapy, surgery. In addition, chemo- radiotherapy potentially toxic could help spread survive. New therapeutic targets against sought, including different signaling pathways distinct cell surface markers. Recent advances nanotechnology have provided hope development new avenues eradicate CSCs. this review, we present newly discovered nanoparticles can be co-loaded with an apoptosis-inducing agent or differentiation-inducing agent, stability, cellular penetration, release. We also summarize molecular characteristics their survival maintenance. Controlled release targeting aims reduce stemness-related suppress growth, prevent relapse metastases.

Language: Английский

Citations

1
Unveiling the future of cancer stem cell therapy: a narrative exploration of emerging innovations DOI Creative Commons

Joseph Nhyira Obisi,

Abike Ndidiamaka Josephine Abimbola,

Oluwasegun Adesina Babaleye

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 22, 2025

Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.

Language: Английский

Citations

1
SF1: A Standardised Fraction of Clinacanthus nutans That Inhibits the Stemness Properties of Cancer Stem-Like Cells Derived from Cervical Cancer DOI Open Access

Faridah Ismail,

Yusmazura Zakaria,

Muhammad Isa

et al.

Sains Malaysiana, Journal Year: 2024, Volume and Issue: 53(3), P. 667 - 679

Published: March 20, 2024

Cancer stem cells (CSCs) are a small population of tumour that responsible for initiation, metastases, recurrence, and resistance to conventional therapy. Hence, targeting CSCs is crucial in the fight against cancer. SF1, standardised fraction from Clinacanthus nutans leaf extract, has been reported exhibit potent selective antineoplastic effects cervical cancer cells. In this study, potential SF1 inhibit stemness stem-like evaluated. extraction was carried out using dry column vacuum chromatography technique. SiHa cell lines were cultured as spheres CSC-conditioned medium (cervospheres), IC50 cervospheres determined OZBlue Cell Viability Kit. The on cervosphere’s markers, including CD49f, CK17, SOX2, OCT4, NANOG, assessed flow cytometry assay. Self-renewal inhibition anti-tumorigenesis evaluated sphere formation assay xenograft mouse model. present study shows treatment at an 17.07 µg/mL inhibited proliferation, self-renewal, tumorigenic capacity vitro vivo. A decrease expressions OCT4 indicated SF1’s inhibitory also associated with suppression markers. These results suggest possesses antitumor effect may be regarded promising approach development targeted anticancer agents

Language: Английский

Citations

8
Unveiling diagnostic and therapeutic strategies for cervical cancer: biomarker discovery through proteomics approaches and exploring the role of cervical cancer stem cells DOI Creative Commons
Ameneh Jafari, Masoumeh Farahani, Meghdad Abdollahpour‐Alitappeh

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 24, 2024

Cervical cancer (CC) is a major global health problem and leading cause of deaths among women worldwide. Early detection through screening programs has reduced mortality; however, compliance remains low. Identifying non-invasive biomarkers proteomics for diagnosis monitoring response to treatment could improve patient outcomes. Here we review recent studies which have uncovered potential drug targets CC. Additionally, explore into the role cervical stem cells their implications in driving CC progression therapy resistance. Although challenges remain, revolutionize field research

Language: Английский

Citations

7
Research Progress of Plant-Derived Natural Products against Drug-Resistant Cancer DOI Open Access
Wenli Liu, Yuqin Wang, Lijie Xia

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 797 - 797

Published: March 11, 2024

As one of the malignant diseases globally, cancer seriously endangers human physical and mental health because its high morbidity mortality. Conventional treatment strategies, such as surgical resection chemoradiotherapy, are effective at early stage but have limited efficacy for advanced cancer. Along with progress treatment, resistance develops gradually within population tumor cells. a consequence, drug become major cause that leads to disease progression poor clinical prognosis in some patients. The mechanisms quite complex involve various molecular cellular mechanisms. Therefore, exploring finding specific targets becoming imperative overcome resistance. In recent years, plant-derived natural products been evaluated potential therapeutic candidates against due low side effects anticancer efficacy. A growing number studies shown can achieve superior antitumor through multiple signaling pathways. include regulation (MDR)-related genes, inhibition phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway, induction autophagy, blockade cell cycle. This paper reviews resistance, well It provides references developing medication drug-resistant effects.

Language: Английский

Citations

6
Public Health Approach in the Elimination and Control of Cervical Cancer: A Review DOI Open Access
John Kessellie Jallah, Ashish Anjankar,

Francis A Nankong

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Public health experts worldwide have emphasized cervical cancer since it is a substantial global burden primarily affecting women. This article thoroughly reviews the public approach to eradicating and managing cancer. The community seeks lower prevalence, morbidity, mortality linked this preventable disease by integrating primary prevention means of vaccination against human papillomavirus (HPV), secondary using screening early identification, tertiary through improved therapy supportive care. In order accomplish broad coverage ultimately effectively prevent cancer, remains crucial address obstacles vaccine accessibility, reluctance, fair distribution. Early identification subsequent treatments depend greatly on programs. study explores several methods, such as Papanicolaou (Pap) tests based cytology cutting-edge technologies like molecular assays HPV detection. detection precancerous lesions early-stage malignancies, permitting prompt treatment, has shown significant promise when these into coordinated population-based also underlines significance addressing inequities, particularly in resource-constrained areas where access preventative curative care constrained. Innovative affordable methods for marginalized groups are studied, including community-based outreach programs, mobile technology, local healthcare practitioners leaders awareness campaigns. research examines improvements treatment procedures, surgery, radiation, chemotherapy, immunotherapy. It improves therapeutic efficacy patient survival rates incorporating various modalities multidisciplinary strategy. Highlighted palliative psychological support patients who advanced carcinoma.

Language: Английский

Citations

11
DNA methyltransferase 1/miR-342-3p/Forkhead box M1 signaling axis promotes self-renewal in cervical cancer stem-like cells in vitro and nude mice models DOI

Xiaozheng Cao,

Yaofeng Zhang, Yuwei Song

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 19, 2025

Cervical cancer (CC) stem cell-like cells (CCSLCs), defined by the capacity of differentiation and self-renewal proliferation, play a significant role in progression CC. However, molecular mechanisms regulating their are poorly understood. Therefore, elucidation epigenetic that drive cell will enhance our ability to improve effectiveness targeted therapies for cells. To explore how DNA methyltransferase 1 (DNMT1)/miR-342-3p/Forkhead box M1 (FoxM1), which have been shown abnormal expression CCSLCs, signaling pathways could stimulate self-renewal-related stemness CCSLCs. Sphere-forming derived from CC lines HeLa, SiHa CaSki served as Self-renewal-related was identified determining sphere colony formation efficiency, CD133 CD49f protein level, SRY-box transcription factor 2 octamer-binding 4 mRNA level. The microRNA profiles between HeLa HeLa-derived CCSLCs or were transfected with without miR-342-3p mimic compared using quantitative PCR analysis. levels DNMT1 mRNA, miR-342-3p, FoxM1 examined real-time western blotting. In vivo carcinogenicity assessed mouse xenograft model. functional effects DNMT1/miR-342-3p/FoxM1 axis vitro gain-of-activity loss-of-activity assessments. Interplay among DNMT1, tested methylation-specific respective luciferase reporter assay. established displayed higher stemness, including enhanced increased heightened transcriptional quantity stemness-related factors well stronger tumorigenic potential parental Moreover, showed level downregulated Its significantly decreased Knockdown transfection suppressed expression, promoter demethylation, inhibited CCSLC self-renewal. Inhibition shRNA also resulted attenuation but had little effect on activity expression. Furthermore, loss exerted inverted overexpression FoxM1. recognized straight targets Our findings suggested novel signal promotes presented target treatment through suppression this pathway has previously implicated CC, evidenced prior studies showing miR-342-3p-mediated downregulation cervical Additionally, research liver further supports involvement suppressing While study contributed body knowledge, we did not present completely reinforced therapeutic targeting suppress treatment.

Language: Английский

Citations

0