Brain Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 100189 - 100189
Published: Feb. 1, 2025
Language: Английский
Chemosensors, Journal Year: 2025, Volume and Issue: 13(1), P. 11 - 11
Published: Jan. 8, 2025
Dual- or multi-template molecularly imprinted polymers have been an attractive research field for many years as they allow simultaneous detection of more than one target with high selectivity and sensitivity by creating template-specific recognition sites multiple targets on the same functional monomer. Dual/multi-template molecular imprinting techniques applied to identify, extract, detect targets, from heavy metal ions viruses, different methods, such high-performance liquid chromatography (HPLC), chromatography–mass spectrometry (LC-MS), piezoelectric, optical, electrochemical methods. This article focuses sensors based dual/multi-template detecting a wide range Furthermore, this work highlights use these point-of-care applications, their commercialization integration microfluidic systems.
Language: Английский
Citations
1
Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Abstract Fast‐scan cyclic voltammetry (FSCV) is a popular approach for real‐time neurochemical sensing. Using carbon‐fiber microelectrode (CFME), sensitive sensing can be achieved in the acute setting with sub‐second resolution monoamine neurotransmitters. However, to study neuropsychiatric conditions and neurological functions, it often of interest perform longitudinal monitoring neurotransmitters over chronic timepoints. Despite notable successes, there remains substantial room improvement performance. Electrode fouling cellular encapsulation that occur following surgical implantation lead diminished sensor performance time. Additionally, working reference electrodes suffer from etching polarization hinder their longevity stability. Here, this work reviews current challenges facing sensors discusses state‐of‐the‐art advancements electrode material device design choices. This covers how biological environment negatively affect mitigate these effects. also provides examples technologies have been developed improve Improvements FSCV as tool neurotransmitter will open new opportunities neurodegenerative diseases, develop feedback systems neuromodulation, explore underpinnings normal brain function behavior.
Language: Английский
Citations
1
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 19, 2025
A critical global concern in the modern era is mental health and well-being, where rapid socioeconomic change, technological advancements, lifestyle shifts have significantly impacted individuals' psychological health. Primary stressors today include urbanization, digital dependency, social isolation, economic pressures, alongside escalating prevalence of disorders such as depression, anxiety, burnout. The COVID-19 pandemic has further exacerbated crises, increasing vulnerability populations during times uncertainty instability. This paper critically examines emerging connections between factors sleep, diet, exercise. Interventions are discussed from a multidimensional perspective, encompassing pharmacological treatments, psychotherapy, tools, community-based programs. Special attention given to rise telemedicine mobile apps, offering innovative solutions bridge gaps healthcare accessibility. Furthermore, review underscores importance preventive approaches, promoting literacy, reducing stigma, fostering resilience through mindfulness, cognitive behavioral techniques, support systems.
Language: Английский
Citations
1
Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(1)
Published: Jan. 20, 2025
Backgrounds: Memory and emotion are especially vulnerable to psychiatric disorders such as post-traumatic stress disorder (PTSD), which is linked disruptions in serotonin (5-HT) metabolism. Over 90% of the 5-HT precursor tryptophan (Trp) metabolized via Trp-kynurenine (KYN) metabolic pathway, generates a variety bioactive molecules. Dysregulation KYN metabolism, particularly low levels kynurenic acid (KYNA), appears be neuropsychiatric disorders. The majority KYNA produced by aadat (kat2) gene-encoded mitochondrial kynurenine aminotransferase (KAT) isotype 2. Little known about consequences deleting enzyme gene. Methods: In CRISPR/Cas9-induced knockout (kat2-/-) mice, we examined effects on emotion, memory, motor function, Trp its metabolite levels, activities plasma urine 8-week-old males compared wild-type mice. Results: Transgenic mice showed more depressive-like behaviors forced swim test, but not tail suspension, anxiety, or memory tests. They also had fewer center field corner entries, shorter walking distances, jumping counts open test. Plasma generally consistent with those urine: antioxidant KYNs, 5-hydroxyindoleacetic acid, indole-3-acetic were lower; KATs, kynureninase, monoamine oxidase/aldehyde dehydrogenase lower, 3-monooxygenase was higher; oxidative excitotoxicity indices higher. displayed depression-like behavior learned helplessness model, emotional indifference, deficits, coupled decrease KYNA, shift metabolism toward KYN-3-hydroxykynurenine partial gut microbial Trp-indole pathway metabolite. Conclusions: This first evidence that gene induces uniquely experiences despair, appear associated excitatory neurotoxic stresses. may lead development double-hit preclinical model despair-based depression, better understanding these complex conditions, effective therapeutic strategies elucidating relationship between PTSD pathogenesis.
Language: Английский
Citations
1
Brain Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 100189 - 100189
Published: Feb. 1, 2025
Language: Английский
Citations
1