SERPINE1AS2 regulates intramuscular adipogenesis by inhibiting PAI1 protein expression DOI

Dianqi Zhang,

Xinhao Ma,

Huaxuan Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133592 - 133592

Published: Aug. 1, 2024

Language: Английский

A review of the role of epigenetic studies for intramuscular fat deposition in beef cattle DOI
Belete Kuraz Abebe, Jianfang Wang, Juntao Guo

et al.

Gene, Journal Year: 2024, Volume and Issue: 908, P. 148295 - 148295

Published: Feb. 21, 2024

Language: Английский

Citations

7

Non-Coding RNAs and Adipogenesis DOI Open Access
Wenxiu Ru, Sihuan Zhang, Jianyong Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 9978 - 9978

Published: June 10, 2023

Adipogenesis is regarded as an intricate network in which multiple transcription factors and signal pathways are involved. Recently, big efforts have focused on understanding the epigenetic mechanisms their involvement regulation of adipocyte development. Multiple studies investigating regulatory role non-coding RNAs (ncRNAs) adipogenesis been reported so far, especially lncRNA, miRNA, circRNA. They regulate gene expression at levels through interactions with proteins, DNA, RNA. Exploring mechanism developments field RNA may provide a new insight to identify therapeutic targets for obesity related diseases. Therefore, this article outlines process adipogenesis, discusses updated roles ncRNAs development adipocytes.

Language: Английский

Citations

12

Novel regulatory role of non-coding RNAs in ankylosing spondylitis DOI Creative Commons
Yanyan Fang, Jian Liu

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 24, 2023

Ankylosing spondylitis (AS) is a type of arthritis that primarily affects the spine and involves disorders immune skeletal systems. However, exact pathogenesis AS not fully understood. Non-coding RNAs (ncRNAs), particularly, long non-coding (lncRNAs), circular (circRNAs), micro (miRNAs) their interactions have been shown to influence many biological processes such as inflammatory responses, osteogenic differentiation apoptosis, pyroptosis, proliferation. In addition, ncRNAs reflect disease activity AS. this review, we discuss regulatory roles in cell functions (inflammatory cellular proliferation) potential applications diagnosis treatment. Understanding role will lay foundation for exploring new therapeutic approaches

Language: Английский

Citations

10

LncIMF1 Promotes Adipogenesis of Porcine Intramuscular Preadipocyte by Sponging miR-187 DOI

Ming Feng,

Xudong Yi, Ziyi Zhang

et al.

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0

Long Non-Coding RNAs in Stem Cell Regulation and Regenerative Medicine: Stemness, Differentiation, and Therapeutic Innovation DOI Creative Commons

Melika Emarati,

Hossein Azizi, Nima Ghasemi

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Long non-coding RNAs (lncRNAs) have emerged as critical regulators in stem cell biology, influencing cellular functions such pluripotency, differentiation, and self-renewal. Their unique ability to modulate gene expression at multiple levels—epigenetic, transcriptional, post-transcriptional—makes lncRNAs powerful tools for controlling fate. In regenerative medicine, understanding the roles of specific can enhance therapeutic approaches, particularly cell-based tissue repair engineering. By modulating lncRNA activity, researchers potentially direct differentiation toward desired lineages, facilitating development functional tissues clinical applications. This chapter explores how influence states, highlights current research therapies, discusses potential future applications where lncRNA-based interventions could drive advancements engineering medicine.

Language: Английский

Citations

0

Unveiling Polysomal Long Non-Coding RNA Expression on the First Day of Adipogenesis and Osteogenesis in Human Adipose-Derived Stem Cells DOI Open Access
Bernardo Bonilauri, Annanda Lyra Ribeiro, Lucía Spangenberg

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2013 - 2013

Published: Feb. 7, 2024

Understanding the intricate molecular mechanisms governing fate of human adipose-derived stem cells (hASCs) is essential for elucidating delicate balance between adipogenic and osteogenic differentiation in both healthy pathological conditions. Long non-coding RNAs (lncRNAs) have emerged as key regulators involved lineage commitment cells, operating at various levels gene regulation, including transcriptional, post-transcriptional, post-translational processes. To gain deeper insights into role lncRNAs’ hASCs’ differentiation, we conducted a comprehensive analysis lncRNA transcriptome (RNA-seq) translatome (polysomal-RNA-seq) during 24 h period adipogenesis osteogenesis. Our findings revealed distinct expression patterns processes, highlighting 90 lncRNAs that are exclusively regulated polysomal fraction. These underscore significance investigating associated with ribosomes, considering their unique potential action, such translational regulation coding capacity microproteins. Additionally, identified specific programs osteogenesis early stages cell differentiation. By shedding light on functions these polysome-associated lncRNAs, aim to deepen our understanding involvement ultimately paving way novel therapeutic strategies regenerative medicine.

Language: Английский

Citations

3

Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (<i>NEAT1</i>) Facilitates Foam Cell Formation and Atherosclerosis Progression Through the miR-17-5p/Itchy E3 Ubiquitin Protein Ligase (ITCH)/Liver Kinase B1 (LKB1) Axis DOI Open Access

Haifen Huang,

Bin Peng, Qingyong Chen

et al.

Circulation Journal, Journal Year: 2024, Volume and Issue: 88(10), P. 1697 - 1708

Published: April 15, 2024

Background: Foam cell formation is an important step for atherosclerosis (AS) progression. We investigated the mechanism by which long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) regulates foam during AS

Language: Английский

Citations

3

LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial cancer by promoting DNMT1-mediated CDO1 promoter hypermethylation DOI Creative Commons

Ruiyu Wang,

Xiuzhang Yu,

Hui Ye

et al.

Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: 300(9), P. 107680 - 107680

Published: Aug. 17, 2024

Endometrial cancer (EC) is the most prevalent gynecological epithelial malignancy. DNA methylation a promising biomarker but limited use for detecting EC. We previously found that level of cysteine dioxygenase 1 (CDO1) promoter was elevated in EC patients through methylomics, role and mechanism CDO1 remained unclear. Here, detected by bisulfite-sequencing PCR methylation-specific (bisulfite conversion-based methods, which remain commonly used techniques detection). Cells were incubated with erastin (the ferroptosis activator). Cell vitality measured using cell counting kit-8 assay. FAM83H-AS1 cellular distribution analyzed fluorescence situ hybridization Lipid reactive oxygen species examined BODIPY-C11 staining. The interactions between FAM83H-AS1, CDO1, methyltransferase1 (DNMT1) RNA-binding protein immunoprecipitation or chromatin xenograft mouse model utilized to test FAM83H-AS1's influence on tumor development vivo. Results showed hypermethylated downregulated knockdown reduced erastin-induced cells. Mechanistically, DNMT1 methyltransferase, can transfer methyl groups cytosine nucleotides genomic DNA. Long noncoding RNA increased inhibited its expression cells recruiting DNMT1. overexpression promoted growth increase inhibit expression.

Language: Английский

Citations

3

Emerging role of mesenchymal stem cell-derived exosomes in the repair of acute kidney injury DOI
Juanjuan Wang, Yu Zheng, Yanlin Li

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 19, 2025

Acute kidney injury (AKI) is a clinical syndrome characterized by rapid deterioration in function and has significant impact on patient health survival. Mesenchymal stem cells (MSCs) have the potential to enhance renal suppressing expression of cell cycle inhibitors reducing senescence markers microRNAs via paracrine endocrine mechanisms. MSC-derived exosomes can alleviate AKI symptoms regulating DNA damage, apoptosis, other related signaling pathways through delivery proteins, microRNAs, long-chain noncoding RNAs, circular RNAs. This technique both safe effective. may great application prospects treatment AKI. Understanding underlying mechanisms will foster development new promising therapeutic strategies against review focused recent advancements role MSCs repair as well their secreted exosomes. It anticipated that novel profound insights into functionality derived emerge.

Language: Английский

Citations

0

Apolipoprotein A-1 Antisense RNA Exacerbates Atherosclerosis by Targeting MicroRNA-185 DOI Open Access
Li Che, Shihao Wu, Bin Zhang

et al.

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: May 26, 2025

Language: Английский

Citations

0