International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133592 - 133592
Published: Aug. 1, 2024
Language: Английский
Gene, Journal Year: 2024, Volume and Issue: 908, P. 148295 - 148295
Published: Feb. 21, 2024
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 9978 - 9978
Published: June 10, 2023
Adipogenesis is regarded as an intricate network in which multiple transcription factors and signal pathways are involved. Recently, big efforts have focused on understanding the epigenetic mechanisms their involvement regulation of adipocyte development. Multiple studies investigating regulatory role non-coding RNAs (ncRNAs) adipogenesis been reported so far, especially lncRNA, miRNA, circRNA. They regulate gene expression at levels through interactions with proteins, DNA, RNA. Exploring mechanism developments field RNA may provide a new insight to identify therapeutic targets for obesity related diseases. Therefore, this article outlines process adipogenesis, discusses updated roles ncRNAs development adipocytes.
Language: Английский
Citations
12
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 24, 2023
Ankylosing spondylitis (AS) is a type of arthritis that primarily affects the spine and involves disorders immune skeletal systems. However, exact pathogenesis AS not fully understood. Non-coding RNAs (ncRNAs), particularly, long non-coding (lncRNAs), circular (circRNAs), micro (miRNAs) their interactions have been shown to influence many biological processes such as inflammatory responses, osteogenic differentiation apoptosis, pyroptosis, proliferation. In addition, ncRNAs reflect disease activity AS. this review, we discuss regulatory roles in cell functions (inflammatory cellular proliferation) potential applications diagnosis treatment. Understanding role will lay foundation for exploring new therapeutic approaches
Language: Английский
Citations
10
Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Language: Английский
Citations
0
IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
Long non-coding RNAs (lncRNAs) have emerged as critical regulators in stem cell biology, influencing cellular functions such pluripotency, differentiation, and self-renewal. Their unique ability to modulate gene expression at multiple levels—epigenetic, transcriptional, post-transcriptional—makes lncRNAs powerful tools for controlling fate. In regenerative medicine, understanding the roles of specific can enhance therapeutic approaches, particularly cell-based tissue repair engineering. By modulating lncRNA activity, researchers potentially direct differentiation toward desired lineages, facilitating development functional tissues clinical applications. This chapter explores how influence states, highlights current research therapies, discusses potential future applications where lncRNA-based interventions could drive advancements engineering medicine.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2013 - 2013
Published: Feb. 7, 2024
Understanding the intricate molecular mechanisms governing fate of human adipose-derived stem cells (hASCs) is essential for elucidating delicate balance between adipogenic and osteogenic differentiation in both healthy pathological conditions. Long non-coding RNAs (lncRNAs) have emerged as key regulators involved lineage commitment cells, operating at various levels gene regulation, including transcriptional, post-transcriptional, post-translational processes. To gain deeper insights into role lncRNAs’ hASCs’ differentiation, we conducted a comprehensive analysis lncRNA transcriptome (RNA-seq) translatome (polysomal-RNA-seq) during 24 h period adipogenesis osteogenesis. Our findings revealed distinct expression patterns processes, highlighting 90 lncRNAs that are exclusively regulated polysomal fraction. These underscore significance investigating associated with ribosomes, considering their unique potential action, such translational regulation coding capacity microproteins. Additionally, identified specific programs osteogenesis early stages cell differentiation. By shedding light on functions these polysome-associated lncRNAs, aim to deepen our understanding involvement ultimately paving way novel therapeutic strategies regenerative medicine.
Language: Английский
Citations
3
Circulation Journal, Journal Year: 2024, Volume and Issue: 88(10), P. 1697 - 1708
Published: April 15, 2024
Background: Foam cell formation is an important step for atherosclerosis (AS) progression. We investigated the mechanism by which long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) regulates foam during AS
Language: Английский
Citations
3
Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: 300(9), P. 107680 - 107680
Published: Aug. 17, 2024
Endometrial cancer (EC) is the most prevalent gynecological epithelial malignancy. DNA methylation a promising biomarker but limited use for detecting EC. We previously found that level of cysteine dioxygenase 1 (CDO1) promoter was elevated in EC patients through methylomics, role and mechanism CDO1 remained unclear. Here, detected by bisulfite-sequencing PCR methylation-specific (bisulfite conversion-based methods, which remain commonly used techniques detection). Cells were incubated with erastin (the ferroptosis activator). Cell vitality measured using cell counting kit-8 assay. FAM83H-AS1 cellular distribution analyzed fluorescence situ hybridization Lipid reactive oxygen species examined BODIPY-C11 staining. The interactions between FAM83H-AS1, CDO1, methyltransferase1 (DNMT1) RNA-binding protein immunoprecipitation or chromatin xenograft mouse model utilized to test FAM83H-AS1's influence on tumor development vivo. Results showed hypermethylated downregulated knockdown reduced erastin-induced cells. Mechanistically, DNMT1 methyltransferase, can transfer methyl groups cytosine nucleotides genomic DNA. Long noncoding RNA increased inhibited its expression cells recruiting DNMT1. overexpression promoted growth increase inhibit expression.
Language: Английский
Citations
3
World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(3)
Published: March 19, 2025
Acute kidney injury (AKI) is a clinical syndrome characterized by rapid deterioration in function and has significant impact on patient health survival. Mesenchymal stem cells (MSCs) have the potential to enhance renal suppressing expression of cell cycle inhibitors reducing senescence markers microRNAs via paracrine endocrine mechanisms. MSC-derived exosomes can alleviate AKI symptoms regulating DNA damage, apoptosis, other related signaling pathways through delivery proteins, microRNAs, long-chain noncoding RNAs, circular RNAs. This technique both safe effective. may great application prospects treatment AKI. Understanding underlying mechanisms will foster development new promising therapeutic strategies against review focused recent advancements role MSCs repair as well their secreted exosomes. It anticipated that novel profound insights into functionality derived emerge.
Language: Английский
Citations
0
Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown
Published: May 26, 2025
Language: Английский
Citations
0