Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 36(1), P. 109752 - 109752
Published: March 11, 2024
Language: Английский
Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111523 - 111523
Published: May 1, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 21, 2023
Atherosclerosis (AS) is the pathology of atherosclerotic cardiovascular diseases (ASCVD), characterized by persistent chronic inflammation in vessel wall, which monocytes/macrophages play a key role. It has been reported that innate immune system cells can assume proinflammatory state after short stimulation with endogenous atherogenic stimuli. The pathogenesis AS be influenced this hyperactivation system, termed trained immunity. Trained immunity also implicated as pathological mechanism, leading to AS. mediated via epigenetic and metabolic reprogramming occurs mature their bone marrow progenitors. Natural products are promising candidates for novel pharmacological agents used prevent or treat (CVD). A variety natural exhibiting antiatherosclerotic abilities have potentially interfere targets This review describes much detail possible mechanisms involved how phytochemicals process inhibit affecting monocytes/macrophages.
Language: Английский
Citations
8
Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)
Published: July 31, 2023
Abstract Osteoarthritis (OA) is a common chronic degenerative joint disease in clinical practice with high prevalence, especially the elderly. Traditional Chinese Medicine (TCM) believes that OA belongs to category of “Bi syndrome” and “bone Bi syndrome”. The etiology pathogenesis lie deficiency liver kidney, Qi blood, external exposure wind, cold, dampness. Epimedium yang-reinforcing herb TCM, which can tonify strengthen muscles bones, dispel cold dampness, treat both symptoms root cause In addition, contains large number ingredients. Through modern science technology, more than 270 compounds have been found , among flavonoids are main active Therefore, our study will review effects mechanisms genus treating from two aspects: (1) Introduction its ingredients; (2) Effects ingredients relevant signaling pathways, order provide ideas for treatment.
Language: Английский
Citations
8
Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(2), P. 025049 - 025049
Published: Feb. 28, 2024
Abstract Osteoporosis (OP) is a common metabolic bone disease. Excessive osteoclastic activity significantly contributes to the development of OP. Icariin (ICA) flavonol glycoside derived from herbal plants and possesses curative effects on postmenopausal OP fracture. This study aimed investigate ICA osteoclast differentiation induced by receptor activator nuclear factor kappa B (RANK) ligand (RANKL) involvement estrogen α (ER ) RANK signaling cascade in this process. RANKL was used induce RAW264.7 cells into osteoclasts. Small interfering RNA technique knockdown ER cells. Cell counting kit-8 assay performed determine cytotoxicity ICA. The number tartrate-resistant acid phosphatase (TRAP)-positive quantified TRAP staining. osteoclasts, while abolished pro-osteoporotic effect RANKL. Moreover, RANKL-induced osteoclastogenesis. Further exploration revealed that inhibited phosphorylation c -Src osteoclasts via regulating , inactivation reversed knockdown-promoted Lastly, activation mitogen-activated protein kinase pathway downregulated expressions target osteoclastogenic proteins RANKL-treated RAW 264.7 cells, almost completely diminished / -Src/RANK signaling. These findings elucidated novel mechanism which exerts an anti-osteoporotic effect.
Language: Английский
Citations
2
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 36(1), P. 109752 - 109752
Published: March 11, 2024
Language: Английский
Citations
2