Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118521 - 118521
Published: July 3, 2024
Sangju Cold Granule (SJCG) is a classical traditional Chinese medicine (TCM) prescription described in "Item Differentiation of Warm Febrile Diseases". Historically, SJCG was employed to treat respiratory illnesses. Despite its popular usage, the alleviating effect on influenza A virus infection and mechanisms have not been fully elucidated.
Language: Английский
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119460 - 119460
Published: Feb. 1, 2025
Fritillaria cirrhosa bulbs, referred to as Chuanbeimu in traditional Chinese medicine (TCM), are extensively used for recognized anti-inflammatory and anti-tussive effects. Both Songbei (SB) Qingbei (QB), which from this plant, have been separately medicine. However, the differences similarities their bioactive components effects remain unclear. We aimed analyse metabolic profiles of F. bulbs across different growth years explore properties two distinct medicinal materials. With nontargeted technology, main were detected. Principal component analysis (PCA) pathway enrichment carried out determine differentially expressed metabolites between years. Network pharmacology was subsequently relationships among components, diseases, key targets, pathways by constructing a network model. The drug-containing serum on cellular inflammatory factors analysed through vitro assays. A total 1349 compounds identified bulb samples. PCA revealed SB (1- 2-year-old) QB (3-, 4-, 5-year-old). Notably, 4-methoxycinnamaldehyde, tenuifoliside A, LysoPC 20:4, morpholine-4-carboximidamide hydrobromide potential distinguishing QB. more common targets related (PPARG, PPARA, PTGS1, XDH) OPRM1, DRD2, SLC6A4, HTR2A) than KEGG that inflammation cough, including tryptophan metabolism arachidonic acid metabolism, enriched group. Cellular assays effects, with having greater IL-6 TNF-α IL-1β overall By integrating metabolomic analyses, classification into based characteristics observed justified certain extent. This study provides new insights, guiding clinical use these treatments cough.
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156574 - 156574
Published: Feb. 27, 2025
Language: Английский
Citations
0
Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Abstract BACKGROUND Prenylated flavonoids are widely distributed in plants, including fruits and vegetables the Moraceae Fabaceae families. These chemicals potential functional food ingredients owing to their attractive biological activities. However, natural prenylated rare, which limits application. RESULTS Here, we reported prenylation of apigenin genistein catalyzed by DMATS1, a dimethylallyl‐ l ‐tryptophan synthase from Fusarium fujikuroi . High‐performance liquid chromatography–tandem mass spectrometry nuclear magnetic resonance identified structure as 6‐ C ‐prenylapigenin (6‐PA) ‐prenylgenistein (6‐PG), respectively. Cell‐based assay suggested that both 6‐PA 6‐PG induced proliferation THP‐1 cells under low concentrations were safe doses less than 50 μmol L −1 exhibited significant anti‐inflammatory activity lipopolysaccharide‐stimulated cells, inhibited production nitric oxide well downregulating transcriptional levels pro‐inflammatory cytokines, tumor necrosis factor‐α, interleukin‐8, interleukin‐1β. CONCLUSION The findings DMATS1 could catalyze genistein, generated activity, aiding recognition nutraceuticals. © 2025 Society Chemical Industry.
Language: Английский
Citations
0
Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)
Published: Feb. 27, 2025
Language: Английский
Citations
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Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127356 - 127356
Published: March 1, 2025
Language: Английский
Citations
0
BMC Veterinary Research, Journal Year: 2025, Volume and Issue: 21(1)
Published: April 2, 2025
In recent years, the livestock industry has shown increasing concern regarding need to find effective alternatives antibiotic products while also striving produce high-quality and poultry products. Woody feed sources exhibit wide distribution variety, containing a variety of bioactive substances such as flavonoids alkaloids. Among these woody plants, Neolamarckia cadamba (Nc) characteristics high leaf yield, fast growth rate, rich nutritional value, which great development potential. However, whether Nc supplementation can improve performance, immunity, gut health yellow-feathered broilers remains be explored. present study, we aimed investigate effects diet supplemented with dry powder or water extract on intestinal broilers. The results showed that, (1) There was no significant difference in Body weight (BW), Average daily gain (ADG), intake (ADFI), Feed conversion ratio (FCR) between experimental groups control group (P > 0.05); (2) Compared group, thymus index at 63 days significantly increased 1% < 0.05). Conversely, bursa Fabricius decreased 0.05) same group; (3) there were differences serum levels albumin (ALB), globulin (GLB), total protein (TP), alanine aminotransferase (ALT), aspartate (AST), triglycerides (TG) each (4) IgG both 0.05% (5) could increase mRNA expression ZO-1 TGF-β4 jejunum, well claudin-1, ZO-1, ileum(P Furthermore, use resulted jejunum ileum These suggest that dietary enhance immune function, small barrier integrity, reduce inflammation certain extent. four doses (1% powder, 2% 0.1% extract), more effective. findings underscore importance exploring alternative additives production, they may offer viable strategy for promoting animal performance absence traditional antibiotics.
Language: Английский
Citations
0
Asian Pacific Journal of Tropical Biomedicine, Journal Year: 2025, Volume and Issue: unknown
Published: May 23, 2025
Objective: To investigate the effect of synbiotic mulberry on kidney injury in a dextran sodium sulfate (DSS)-induced colitis model. Methods: Male Wistar rats were given drinking water containing 4% DSS for 7 days. Subsequently, treated by oral gavage with at 250, 500, and 1 000 mg/kg, sulfasalazine 100 or 1000 mg/kg an additional days while receiving 0.4% water. The severity was evaluated based disease activity index score. On day 14, plasma collected, kidneys harvested to evaluate parameters histological changes. In addition, expression genes associated determined quantitative RT-PCR. Results: Treatment all doses significantly lowered score, accompanied reductions histopathological changes, malondialdehyde concentration, cystatin C levels. Kidney fibrosis also ameliorated 500 mulberry. 250 downregulated IL-18 mRNA expression, KIM-1 reduced lipopolysaccharide-binding protein level restored Conclusions: Synbiotic ameliorates DSS-induced colitis. It may be further explored as treatment under conditions.
Language: Английский
Citations
0
Biology, Journal Year: 2023, Volume and Issue: 12(10), P. 1333 - 1333
Published: Oct. 13, 2023
Fruits contain many bioactive compounds, including polysaccharides, oligosaccharides, polyphenols, anthocyanins, and flavonoids. All of these bioactives in fruit have potentially beneficial effects on gut microbiota host health. On the one hand, rich active ingredients can act as substrates to interact with microorganisms produce metabolites regulate microbiota. other microbes could promote health by balancing dysbiosis We extensively analyzed significant information components fruits based Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA). Although deep mechanism action needs further study, results also provide supportive a source dietary support adjunctive role disease prevention treatment.
Language: Английский
Citations
9
Plant Signaling & Behavior, Journal Year: 2023, Volume and Issue: 18(1)
Published: Nov. 28, 2023
Mulberry leaves are served not only as fodder for silkworms but also potential functional food, exhibiting nutritional and medical benefits due to the complex diverse constituents, including alkaloids, flavonoids, phenolic acids, benzofurans, which possess a wide range of biological activities, such anti-diabete, anti-oxidant, anti-inflammatory, so on. Nevertheless, compared with well-studied phytochemistry pharmacology mulberry leaves, current understanding biosynthesis mechanisms regulatory active ingredients in remain unclear. Natural resources these limited owing their low contents tissues long growth cycle mulberry. Biosynthesis is emerging an alternative means accumulation desired high-value compounds, can broaden channels large-scale green productions. Therefore, this review summarizes recent research advance on correlative key genes, enzyme biocatalytic reactions biosynthetic pathways valuable natural (i.e. benzofurans) thereby offering important insights further biomanufacturing.
Language: Английский
Citations
9
Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 101074 - 101074
Published: Aug. 1, 2024
Inflammatory bowel disease (IBD) is a chronic and recurrent intestinal disease, has become major global health issue. Individuals with IBD face an elevated risk of developing colorectal cancer (CRC), recent studies have indicated that mitochondrial dysfunction plays pivotal role in the pathogenesis both CRC. This review covers CRC, focusing on dysfunction, explores pharmacological targets strategies for addressing conditions by modulating function. Additionally, advancements modulation treating encompassing damage, release DNA (mtDNA), impairment mitophagy, are thoroughly summarized. The also provides systematic overview natural compounds (such as flavonoids, alkaloids, diterpenoids), Chinese medicines, microbiota, which can alleviate attenuate progression CRC In future, it will be imperative to develop more practical methodologies real-time monitoring accurate detection function, greatly aid scientists identifying effective agents through
Language: Английский
Citations
3