Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice

Immunity & Ageing, Journal Year: 2022, Volume and Issue: 19(1)

Published: Dec. 22, 2022

Obesity rates are increasing worldwide. leads to many complications, including predisposing individuals the development of cognitive impairment as they age. Immune dysregulation, inflammaging (e.g., increased circulating cytokines) and immunosenescence (declining immune system function), commonly occur in obesity aging may impact impairment. As such, changes across lifespan effects on neuroinflammation associated However, role age obesity-induced is unclear. To further define this putative relationship, current study examined metabolic inflammatory profiles, along with using a high-fat diet (HFD) mouse model obesity.

Language: Английский

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Effects of High-Fat and High-Fat High-Sugar Diets in the Anxiety, Learning and Memory, and in the Hippocampus Neurogenesis and Neuroinflammation of Aged Rats

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1370 - 1370

Published: March 11, 2023

High-caloric diets induce several deleterious alterations in the human body, including brain. However, information on effects of these elderly brain is scarce. Therefore, we studied 2 months treatment with high-fat (HF) and high-fat-high-sugar (HFHS) aged male Wistar rats at 18 months. Anxiety levels were analyzed using open-field plus-maze tests, while learning memory processes Morris water maze test. We also neurogenesis doublecortin (DCX) neuroinflammation glial fibrillary acidic protein (GFAP). In rats, HFHS diet impaired spatial learning, memory, working increased anxiety levels, associated a reduction number DCX cells an increase GFAP hippocampus. contrast, HF lighter, impairing Thus, our results suggest that are highly susceptible to high-caloric diets, even if they only started elderly, impact cognition emotions. Furthermore, rich saturated fats sugar more detrimental than are.

Language: Английский

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High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 119, P. 236 - 250

Published: April 9, 2024

Language: Английский

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Untargeted Metabolomics Revealed that Quercetin Inhibited Ferroptosis by Improving Metabolic Disorder in the Hippocampus of Perimenopausal Depression Model Rats

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 24, 2024

Language: Английский

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JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111218 - 111218

Published: Jan. 1, 2025

Language: Английский

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Age-Related Differences in Lipopolysaccharide-Induced Delirium-like Behavior Implicate the Distinct Microglial Composition in the Hippocampus

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2055 - 2055

Published: Feb. 26, 2025

As the global population ages, mechanisms underlying age-related susceptibility to delirium have attracted attention. Given central role of microglia in pathogenesis inflammation-related delirium, we investigated temporal dynamics neurobehavioral changes and microglial responses, following lipopolysaccharide (LPS, 200 μg/kg) administration young old male C57BL/6 mice. Although a similar illness trajectory across 48 h post-treatment (HPT) was observed both age groups, old-LPS mice exhibited worsened delirium-like behavior. At HPT, but not mice, significantly decreased hippocampal neuronal activity coincided with overactivation. Widespread activation present at 3 HPT subsided by 12 indicating generally retarded prolonged response LPS challenge However, for p16INK4a-negative (with low abundance aged brain) comparable morphological activation, which p16INK4a-positive (highly abundant brain). These results suggest that LPS-induced behavior accompanied different patterns might implicate composition shifts optimizing represents promising approach reduce vulnerability inflammatory challenge.

Language: Английский

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Behavioral and pathological characteristics of 5xFAD female mice in the early stage

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

Alzheimer's disease (AD) is a central nervous system degenerative with insidious onset and gradual development caused by selective progressive loss of neurons. The 5xFAD mouse relatively mature model AD. However, the behavioral research on female more focused changes late memory function, exploration its early pathological still incomplete. This aims to explore in emotional function (including anxiety depression), motor ability, amyloid plaques, glial cell response neurogenesis hippocampus mice stage, laying foundation for comprehensive mechanism results this study found that 4-month-old mainly showed decline without other dysfunction. Accompanied large amount protein plaques deposited hippocampus, it induced microglia astrocytes, decreased significantly age, especially mice, which resulted decrease number new may be an important reason stage.

Language: Английский

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AdipoRon Attenuates Depression-Like Behavior in T2DM Mice via Inhibiting Inflammation and Regulating Autophagy

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111308 - 111308

Published: March 1, 2025

Language: Английский

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Minocycline treatment attenuates neurobehavioural abnormalities and neurostructural aberrations in the medial prefrontal cortex in mice fed a high-fat diet during adolescence

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9394 - 9394

Published: May 28, 2023

The association between a high-fat diet (HFD) consumption and emotional/cognitive disorders is widely documented. One distinctive feature of the prefrontal cortex (PFC), kernel emotion- cognition-related brain region, its protracted adolescent maturation, which makes it highly vulnerable to detrimental effects environmental factors during adolescence. Disruption PFC structure function linked disorders, especially those that emerge in late A HFD common among adolescents, yet potential on PFC-related neurobehavior adolescence any related underlying mechanisms are be established. In present study, (postnatal days 28–56) male C57BL/6J mice were fed control (CD) or underwent behavioral tests addition Golgi staining immunofluorescence targeting medial (mPFC). HFD-fed exhibited anxiety- depression-like behavior abnormal mPFC pyramidal neuronal morphology accompanied by alterations microglial indicative heightened state activation increased PSD95+ inclusions signifying excessive phagocytosis synaptic material mPFC. These findings offer novel insights into neurobehavioral due suggest contributing role dysfunction neuroplasticity deficits for HFD-associated mood adolescents.

Language: Английский

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