Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 21, 2025
Language: Английский
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 18, 2025
Ischemic stroke (IS) as a detrimental neurological disease is accompanied by oxidative-stress-induced injury, concurrent inflammatory response, overactivated brain immune microenvironment, and disruption of the blood-brain barrier (BBB). This cascade events ultimately leads to neuronal death significantly impairs recovery function. In this study, we presented extracellular vesicles derived from gut probiotic Lactobacillus reuteri (LrEVs) integrated with targeting, reactive oxygen species (ROS) scavenging, reduced infiltration cells for effective multiple therapeutic interventions IS. LrEVs inherited peptidoglycan (PGN) specifically targeted upregulated toll-like receptor 2 (TLR2) in injured region ischemic brain, achieving penetration BBB accumulation brain. meantime, prevented apoptosis after scavenging ROS overproduction modulating microglial polarization through inhibition MAPK NF-κB pathways. Furthermore, inhibited aggregation C-C motif chemokine ligand (CCL2), peripheral such macrophages neutrophils into tissue, suppressed impairment BBB, thereby improving microenvironment. The findings provide vesicle that combines modulation showcasing potential gut-probiotic-derived treat damage.
Language: Английский
Citations
0
Cell & Bioscience, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 19, 2025
Abstract The phenomenon of endothelial–mesenchymal transition (EndMT), a distinct subtype epithelial–mesenchymal (EMT), has garnered significant attention from scholars. EndMT refers to the process whereby endothelial cells (ECs) transform into mesenchymal in response various stimuli, resulting loss their original characteristics. This diverse implications both physiological and pathological states. Under conditions, plays crucial role development cardiovascular system. Conversely, under been identified as pivotal factor diseases. Nonetheless, comprehensive overview cerebrovascular disease is currently lacking. Here, we discuss heterogeneity occurrence regulatory factors involved its analyze feasibility therapeutic target, aiming provide solid theoretical foundation evidence address diseases caused by EndMT.
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 21, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3915 - 3915
Published: April 21, 2025
Neurological diseases, including neurodegenerative disorders and stroke, represent significant medical challenges due to their complexity the limitations of current treatment approaches. This review explores potential stem cell (SC)-derived exosomes (Exos) as a transformative therapeutic strategy for these diseases. Exos, especially those derived from SCs, exhibit natural targeting ability, biocompatibility, capacity cross blood-brain barrier (BBB), making them ideal vehicles drug delivery. provides an in-depth discussion properties advantages SC-Exos. It highlights synergistic benefits in approaches treat neurological article discusses mechanisms action SC-Exos, highlighting ability target specific cells, modulate disease pathways, provide controlled release agents. Applications have been investigated, demonstrating improve outcomes conditions such Alzheimer's Disease (AD), Parkinson's (PD), stroke. Moreover, Exos-coated nanoparticles (NPs) combine Exos with multifunctionality NPs. integration takes advantage exosome membrane biocompatibility capabilities while preserving NPs' beneficial features, loading release. As result, NPs may enhance precision, efficacy, safety interventions. In conclusion, SC-Exos promising innovative approach treating
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 21, 2025
Language: Английский
Citations
0