HPV-related diseases in male patients: an underestimated conundrum

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 47(2), P. 261 - 274

Published: Sept. 28, 2023

Abstract Purpose Human papillomavirus (HPV) infection is the most common sexually transmitted disease, in males and females worldwide. While role of HPV female diseases well known largely studied, have negligibly been included these programs, also because proportion women suffering dying from HPV-related much larger than men. The aim this review to focus on male patients. Methods We performed a literature analysis electronic database PubMed. considered randomized trials, observational retrospective studies, original articles having as topic relationship between following items: oral, anal penile cancers, warts, condylomas, infertility, altered sperm parameters, anti-sperm antibodies (ASA). experimental vitro studies focused effects oocyte fertilization, blastocyst development, trophoblastic cell invasiveness. In addition, describing adjuvant administration vaccination possible strategy promote clearance semen infected were included. Results Regarding head neck diseases, important non-neoplastic disease recurrent respiratory papillomatosis (RRP). neoplastic cancers attributable has increased dramatically nowadays, it thought that half squamous carcinomas (HNSCCs) cases United States are caused by with high-risk HPV. noteworthy andrological practice too. It was described high prevalence, ranging 50 70%, shaft, glans penis/coronal sulcus, scrotal, perianal, regions. Moreover, patients, associated, among other cancers. reported about 10% men general population 16% unexplained although data seem widely underestimated according clinical experience. particular, seems be related asthenozoospermia (ASAs). Conclusions represents health problem detrimental social public impact. Despite evidence, little done date young males.

Language: Английский

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Advances in immunotherapy for gynecological malignancies

Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 188, P. 104063 - 104063

Published: June 28, 2023

Language: Английский

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Reappraisal of p16 for Determining HPV Status of Head and Neck Carcinomas Arising in HPV Hotspots

The American Journal of Surgical Pathology, Journal Year: 2024, Volume and Issue: 48(5), P. 581 - 587

Published: March 14, 2024

In an era of head and neck oncology where HPV status will soon dictate patient management, reliable detection is critical. P16 immunohistochemistry (IHC) currently recommended as the test choice for oropharyngeal squamous cell carcinomas (OPSCCs). The purpose this study was to determine performance characteristics p16 IHC based on a large clinical experience (SCC) arising from hot-spot regions neck. Consecutive OPSCCs, sinonasal SCCs, metastatic SCCs unknown primary sites were evaluated presence by PCR-based DNA testing part care. For discrepant cases, high-risk E6/E7 mRNA in situ hybridization (ISH) and, when possible, matrix-assisted laser desorption/ionization—time flight (MALDI-TOF) mass spectrometry (MassArray) genotyping performed. 746 cancers underwent PCR genotyping. There 95.6% concordance between 2 assays. Of 33 32 cases (4.3%) positive but negative. these 68% ISH, invariably related non-16 genotype. had overall accuracy 98.8%, sensitivity 99.8%, specificity 92.1%. sensitive specific assay determining status. appears vulnerable genotype diversity prone missing rare genotypes. ISH practical direct measure that may help eliminate small number false-positive avoid potential harm erroneous classification.

Language: Английский

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Sex-specific aspects in patients with oropharyngeal squamous cell carcinoma: a bicentric cohort study

BMC Cancer, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 2, 2023

Oropharyngeal squamous cell carcinoma (OPSCC) is the only subgroup of head neck cancer that presents with an increased incidence. Gender-specific studies in other entities have revealed differences treatment response and prognosis. However, limited data OPSCC according to gender human papillomavirus (HPV) status exist. Therefore, we aimed investigate sex-specific how these may be distributed relation HPV risk factors.This retrospective, bicentric study included 1629 patients diagnosed between 1992 2020. We formed subgroups based on TNM status, American Joint Cancer Committee 8th edition (AJCC8), modality (surgery (± radio(chemo)therapy (RCT) vs. definitive RCT) patient-related factors investigated their impact survival via descriptive-,uni- multivariate analysis.With exception alcohol abuse, no significant were found men women. Females presented better OS than males T1-2, N + , independent (p = 0.008). Males demonstrated stratification through all AJCC8 stages (all p < 0.050). In contrast, women lacking significance stage II III 0.992). With regard therapy R(C)T) - treated surgery had whole cohort Similar results detected HPV-negative sub-cohort 0.042) high-risk groups (AJCC8 IV M0, 0.003).Sex-specific represent a health disparity, particularly staging treatment, which need addressed future studies.

Language: Английский

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HPV vaccination for prevention of head and neck cancer among men

The Nurse Practitioner, Journal Year: 2023, Volume and Issue: 48(10), P. 25 - 32

Published: Sept. 26, 2023

The incidence of human papillomavirus (HPV)-associated head and neck cancer (HNC) has been rapidly increasing in developed countries, with HPV-associated HNC now accounting for 70% all cases. An increased noted particularly among males. disparities HPV vaccine uptake rates the number individuals suggest a lack public awareness both sequelae prevention options. This review highlights importance prophylactic vaccination preventing HNC, Current evidence substantiates need gender-neutral programs reinforces recommendations made by CDC. article raises association between as well effectiveness prevention.

Language: Английский

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Therapeutic Advances and Challenges for the Management of HPV-Associated Oropharyngeal Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4009 - 4009

Published: April 3, 2024

The use of conventional chemotherapy in conjunction with targeted and immunotherapy drugs has emerged as an option to limit the severity side effects patients diagnosed head neck cancer (HNC), particularly oropharyngeal (OPC). OPC prevalence increased exponentially past 30 years due human papillomavirus (HPV) infection. This study reports a comprehensive review clinical trials registered public databases reported literature (PubMed/Medline, Scopus, ISI web science databases). Of 55 identified, majority (83.3%) were conducted after 2015, which 77.7% performed United States alone. Eight have been approved by FDA for HNC, including both generic commercial forms: bleomycin sulfate, cetuximab (Erbitux), docetaxel (Taxotere), hydroxyurea (Hydrea), pembrolizumab (Keytruda), loqtorzi (Toripalimab-tpzi), methotrexate sodium (Trexall), nivolumab (Opdivo). most common treat HPV-associated under these implemented well HPV-negative HNC include cisplatin, nivolumab, cetuximab, paclitaxel, pembrolizumab, 5-fluorouracil, docetaxel. Few studies highlighted necessity new specifically tailored OPC, where molecular mechanisms prognosis are distinct from tumors. In this context, we identified mutated genes found that can represent potential targets drug development. These TP53, PIK3CA, PTEN, NOTCH1, RB1, FAT1, FBXW7, HRAS, KRAS, CDKN2A.

Language: Английский

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Perceptions of HPV-Linked Oropharyngeal Cancer Risk Messages Among a Sample of Young Adult Men in the US: A Pilot Study

American Journal of Men s Health, Journal Year: 2024, Volume and Issue: 18(3)

Published: May 1, 2024

Awareness of risk for oropharyngeal cancer from oral human papillomavirus (HPV) infection is low among men in the United States. This pilot study tested messages communicating HPV and a sample U.S. young adult (aged 18–26). Six were an online survey. Participants ( N = 68) randomly assigned to one two message sets, each containing three unique text-based messages. evaluated separately based on various measures (e.g., perceived effectiveness [PME], novelty). One-way repeated ANOVAs used assess evaluation differences within sets. provided open-ended feedback about message, which synthesized into overarching themes. receptive messages, rating them high PME (mean range 3.72–4.25 out 5) other measures. Analyses identified high-performing For example, participants rated HPV-linked rates versus women higher attention novelty than same set (both ps < .05). shown (instead all six) minimize survey fatigue. Common themes that liked short-form structure gender-tailored language. In conclusion, may be useful increasing awareness Further work should test such rigorous experimental contexts their efficacy modifying health outcomes, as vaccination behaviors.

Language: Английский

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Typing of Vulvar Squamous Cell Carcinoma: Why it is Important?

Advances in Anatomic Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

The classification of vulvar squamous cell carcinoma (VSCC), as in endometrial cancer, has shifted from the histology-based descriptors toward molecular-based identifiers. Recently, it been reported that there are 3 genetically distinct and clinically significant subtypes VSCC: HPV-associated VSCC, HPV-independent/p53 wild-type HPV-independent/p53-mutated VSCC. Each group different prognostic implications well response to treatment, thus reinforcing need for this 3-tier molecular classification. This subtyping can easily be done on biopsies using p16 p53 immunohistochemistry stains further improve risk prediction individualized treatment decisions, leading better patient outcomes.

Language: Английский

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Virus del papiloma humano como factor etiopatogénico en el desarrollo de cáncer oro faríngeo: Revisión Bibliográfica

MQRInvestigar, Journal Year: 2024, Volume and Issue: 8(1), P. 186 - 203

Published: Jan. 8, 2024

Introducción: El Virus del Papiloma Humano (VPH) se ha identificado como un factor etiológico significativo en el desarrollo cáncer orofaríngeo, particularmente carcinoma de células escamosas. Objetivo: Evaluar la relación entre infección por VPH y incidencia, progresión pronóstico orofaríngeo. Metodología: Se realizó una revisión bibliográfica exhaustiva bases datos PubMed, Scopus Google Scholar, utilizando palabras clave relacionadas con orofaríngeo. incluyeron estudios desde 2019 hasta 2023, abarcando investigaciones clínicas, análisis epidemiológicos revisiones. Resultados: Los revelaron que VPH, especialmente serotipo 16, está asociado aumento incidencia afectando principalmente a pacientes más jóvenes menos factores riesgo tradicionales. positivo presentaron mejor supervivencia comparación los negativo. La también destacó importancia vacunación estrategia preventiva. Conclusiones: es etiopatogénico implicaciones significativas gestión clínica enfermedad. emerge herramienta crucial prevención. Sin embargo, necesario mejorar las tasas detección temprana para combatir eficazmente

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The role of human papillomavirus in laryngeal cancer and recurrent respiratory papillomatosis: epidemiological and clinical aspects

Head and neck tumors (HNT), Journal Year: 2024, Volume and Issue: 14(2), P. 76 - 84

Published: Aug. 4, 2024

In the recent decade, number of laryngeal cancer cases increased worldwide by 23 %. Currently, morbidity and associated mortality do not show statistically significant trends toward a decrease. The main risk factors for carcinoma are smoking, alcohol consumption, human papilloma virus (HPV) infection, recurrent respiratory papillomatosis, genetic predisposition. Aim. To evaluate incidence role HPV in etiology clinical course papillomatosis. Analysis available literature sources published Medline, Pubmed, eLibrary databases was performed. review is based on 59 584 identified scientific studies. Frequency detection tumor tissue varies with studied country’s geographical location. these viruses between 2.7 62.6 Genotype 16 more common women ages 31 40 years mostly located near glottic aperture. 6 11 promote development papillomatosis larynx detected 0–87.5 % cases. It noted that patients HPV-positive neoplasms larynx, better response to radiation therapy higher survival rates observed compared without virus. countries where national programs vaccination against infection have been implemented, decrease observed. varies. carcinogenesis has yet fully understood. Clinical HPV-associated favorable than HPV-free carcinoma, however, this statement requires further confirmation. Evaluation results their effect important.

Language: Английский

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