The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model

Neurotoxicity Research, Journal Year: 2025, Volume and Issue: 43(2)

Published: Feb. 28, 2025

Language: Английский

---

Molecular Regulation and Therapeutic Applications of Brain-Derived Neurotrophic Factor–Tropomyosin-Related Kinase B Signaling in Major Depressive Disorder Though Its Interaction with Vascular Endothelial Growth Factor and N-Methyl-D-Aspartic Acid Receptors: A Narrative Review

Biologics, Journal Year: 2025, Volume and Issue: 5(1), P. 7 - 7

Published: March 3, 2025

The molecular regulation and therapeutic applications of brain-derived neurotrophic factor (BDNF)–tropomyosin-related kinase B (TrkB) signaling in major depressive disorder (MDD) through interaction with vascular endothelial growth (VEGF) N-methyl-D-aspartic acid (NMDA) receptors show promise. While BDNF-TrkB is implicated antidepressant action, the association between BDNFs depression has not yielded conclusive results. Some studies decreased BDNF levels depression, while others indicate that increased expression certain brain regions can induce susceptibility. role varies across different regions, necessitating further study individual mechanisms. This regional variability complicates development targeted therapies. antidepressant-like actions require VEGF signaling, but there also a reciprocal interdependence, as are dependent on BDNFs. complex relationship

Language: Английский

---

Exploring Alzheimer's Disease Treatment: Established Therapies and Novel Strategies for Future Care

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177520 - 177520

Published: March 1, 2025

Language: Английский

---

The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep

Mediators of Inflammation, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

According to statistics, more than one‐third of the global population currently experiences sleep problems, and about 10% adults have been diagnosed with insomnia, a proportion that is increasing annually. Most used insomnia medications are not specifically developed but discovered by chance, often resulting in unavoidable side effects like addiction. Thus, there an urgent need find safer effective therapeutic options. Resveratrol, natural polyphenolic compound, shows significant potential improving insomnia. Research its may be achieved through multiple biological processes, including antiapoptosis, antioxidant activity, anti‐inflammation, circadian rhythm regulation, modulation neurotransmitters (gamma‐aminobutyric acid (GABA), DA, 5‐HT, cortisol), increased levels neurotrophic factor BDNF. Additionally, resveratrol’s treatment closely linked SIRT1, AMPK, NF‐ κ B, mTOR, PI3K/Akt, MAPK pathways. This review summarizes mechanisms resveratrol treating provide researchers deeper understanding action, which can aid development novel targeted drugs offer innovative ideas methods for clinical treatment.

Language: Английский

---

Assessing Causality Between Plasma Brain‐Derived Neurotrophic Factor With Major Depression Disorder: A Bidirectional Mendelian Randomization Study

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

ABSTRACT Purpose This study employed a two‐sample Mendelian randomization (MR) approach to investigate the bidirectional relationship between brain‐derived neurotrophic factor (BDNF) and major depressive disorder (MDD), addressing gaps left by prior observational studies. Methods We utilized Genome‐Wide Association Study (GWAS) datasets, including MDD information from Psychiatric Genomics Consortium (PGC) UK Biobank ( N = 500,199), along with plasma BDNF measurements FinnGen 619). In subsequent phase, we analyzed data 448,069) three additional GWAS sources: 33,924), deCODE 35,353), INTERVAL 3301). Multiple MR methods were applied ensure robust analysis. Results The inverse variance weighted (IVW) method revealed no significant association levels risk of developing (IVW odds ratio [OR] 1.00, 95% confidence interval [CI] 0.99–1.01, p 0.769). Similarly, causal effect gene on was identified (OR 0.91, CI 0.23–3.56, 0.893). Furthermore, there evidence supporting link 0.99, 0.89–1.09, 0.783). second phase analysis confirmed absence relationships. Conclusion provides MDD. These findings prompt re‐evaluation as biomarker for emphasize need further investigation into its functional role within well activity in brain cerebrospinal fluid.

Language: Английский

---

Investigative assessment of the neuro-modulatory potentials of cannabichromene in TrkB/BDNF-mediated neurosignaling pathway

Comparative Clinical Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Language: Английский

---

The combined damage of bisphenol A and high fat diet to learning and memory in young male mice: the regulatory effect of BDNF/TrkB/PI3K/AKT pathway on autophagy

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121538 - 121538

Published: April 1, 2025

Language: Английский

---

Sex differences in the mediating role of brain-derived neurotrophic factor between inflammation and memory in cirrhotic patients with minimal hepatic encephalopathy

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: unknown, P. 100998 - 100998

Published: April 1, 2025

Language: Английский

---

Amomum tsao‐ko Attenuates Hyperglycemia and Cognitive Impairment via Regulating Gut Microbiota, SCFAs, and CREB/BDNF/TrkB Signaling Pathway in T2DM Mice

Neurogastroenterology & Motility, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

ABSTRACT Background As a medicine‐food fruit, Amomum tsao‐ko has been reported to be beneficial for the management of diabetes. However, its effects and mechanisms in cognitive impairment caused by diabetes remain unclear. This study aimed investigate influences A. on type 2 mellitus (T2DM) mice associated mechanisms. Methods was characterized using UHPLC‐Q‐Orbitrap‐MS/MS. T2DM induced high‐fat diet combined with streptozotocin were treated ethanol extract (EEAT) 8 weeks. The function evaluated Morris water maze (MWM) test, open field test (OFT), novel object recognition (NORT). Hippocampus colon tissues used histopathology, biochemical assays, or protein expression analysis. Additionally, fecal samples subjected 16S rRNA gene sequencing short‐chain fatty acids (SCFAs) detection. Key Results findings demonstrated that EEAT significantly reversed glucose metabolism disorders deficits mice. It promoted CREB/BDNF/TrkB pathway reduced hippocampal inflammatory responses, thereby improving neuronal damage. inhibited loss colonic tight junction proteins, decreased levels factors colon, also reshaped gut microbiota increased SCFAs. Notably, Spearman's correlation analysis indicated Lachnospiraceae NK4A136 group , Ruminococcaceae UCG‐014 Lactobacillus Blautia Lachnoclostridium obviously correlated (positive negative) homeostasis indexes, behavioral tissue factors, Conclusions regulating microbiota, SCFAs, may potential alleviating diabetes, which provides option treat diabetic impairment.

Language: Английский

---

Selection of sciatic nerve injury models: implications for pathogenesis and treatment

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 7, 2025

Sciatic nerve injury is one of the most frequent peripheral injuries in world. The loss motor and sensory function, along with chronic pain caused by sciatic injury, significantly impacts patients’ quality life. However, there are numerous restrictions on vitro studies regeneration healing damage. In contrast, vivo can more accurately mimic clinical pathology through a variety experimental animal models modeling methods. selection different has its focus, so this paper reviews animals, methods, common treatment protocols. advantages disadvantages each species discussed, methods five models, their characteristics applications, highlighted. Additionally, we briefly summarize treatments for sciatica injury. This review great significance further exploring model selection, mechanisms underlying therapies repair.

Language: Английский

---