Protection against Microglia Senescence by the Dietary Supplement Dekosilhue® in BV2 Cells: A New Perspective for Obesity and Related Complications DOI Creative Commons
Vittoria Borgonetti, Chiara Sasia, Martina Morozzi

et al.

Nutraceuticals, Journal Year: 2023, Volume and Issue: 3(2), P. 250 - 261

Published: May 23, 2023

Growing evidence indicates chronic low-grade systemic inflammation as a major pathophysiological mechanism of obesity. Systemic provokes an immune response in the brain through activation microglia that results development neuroinflammation, cellular senescence, and occurrence neurological dysfunction. In efforts to identify innovative intervention with potential efficacy on obesity associated complications, our aim was study capability dietary supplement Dekosilhue® (DKS), successfully used for improving control body weight, attenuate senescent phenotype. Microglia senescence induced by intermittent stimulation BV2 cells LPS 500 ng/mL every 72 h 4 h/day, over period 10 days. DKS (100 µg/mL) treatment reduced ß-galactosidase activity expression, formation senescence-associated heterochromatin foci levels, increased cell viability (2 folds control). DSK expression Nuclear Factor-kB (NF-kB) (20% lower than control), key molecule involved acquisition secretory phenotype (SASP). promoted neuroprotective effect increasing SH-SY5Y neuronal exposed conditioned medium values non-senescent cells. conclusion, attenuated phenotype, showing senotherapeutic might be further investigated adjunctive obesity-related disturbances.

Language: Английский

Body Composition and Alzheimer’s Disease: A Holistic Review DOI Open Access
Giulia Frank, Paola Gualtieri, Rossella Cianci

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9573 - 9573

Published: Sept. 4, 2024

Alzheimer’s disease (AD) represents a significant global health challenge and affects approximately 50 million people worldwide. This overview of published reviews provides comprehensive understanding the intricate correlations between AD body composition, focusing particularly on obesity. We used systematic approach to collect analyze relevant topic obesity disease. A search electronic databases, including PubMed, MEDLINE, Google Scholar, was conducted. searched keywords such as “Alzheimer’s disease”, “body composition”, “lean mass”, “bone “fat mass”. considered only written within past 5 years in English. Fifty-six were identified that shed light multiple connections composition. The review involves several aspects, impact lean mass, bone endocrinological factors related obesity, well inflammation, neuroinflammation, molecular/genetic factors. findings highlight complex interplay these elements development AD, underscoring need for holistic approaches reduce risk explore innovative strategies diagnosis, prevention, treatment.

Language: Английский

Citations

1
Neuroprotective Roles of Lauric Acid and Resveratrol: Shared Benefits in Neuroinflammation and Anxiety, Distinct Effects on Memory Enhancement DOI Creative Commons
Betul Kisioglu, Esra Önal, Derya Karabulut

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(11), P. 9735 - 9748

Published: Oct. 23, 2024

ABSTRACT Neuroinflammation can be triggered by a high‐fat/high‐fructose diet (HFFD), and CD36 may an underlying mechanism. Lauric acid (LA), the major fatty in coconut oil, resveratrol, plant‐based polyphenolic compound, exert anti‐inflammatory effects. Therefore, this study investigated possible effects of LA resveratrol on diet‐induced neuroinflammation CD36. Healthy male C57BL/6 mice (8 weeks age, n = 31) were fed control (10%kcal fat) or diets containing high fat (60%kcal fructose (5% w/v drinking water) for 6 weeks, ad libitum . Supplemented to HFFD, daily received (7.5 mg/kg) (HFFD‐RSV) (750 (HFFD‐LA). At end study, HFFD resulted anxiety‐like behavior, reduced locomotor activity, (increased brain GFAP, IL‐6, MCP‐1, IFN‐γ, TNF‐α), systemic inflammation plasma TNF‐α, IL‐12p70, IL‐10). HFFD‐RSV HFFD‐LA alleviated HFFD‐induced neuroinflammation, inflammation. improved memory. Brain levels increased HFFD‐LA. Dietary intake alleviate inflammation, behavior improve memory, as

Language: Английский

Citations

1
Neurometabolic Profile in Obese Patients: A Cerebral Multivoxel Magnetic Resonance Study DOI Creative Commons
Miloš Vuković, Igor Nosek, Johannes Slotboom

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(11), P. 1880 - 1880

Published: Nov. 16, 2024

Obesity-related chronic inflammation may lead to neuroinflammation and neurodegeneration. This study aimed evaluate the neurometabolic profile of obese patients using cerebral multivoxel magnetic resonance spectroscopy (mvMRS) assess correlations between brain metabolites obesity markers, including body mass index (BMI), waist circumference, waist-hip ratio, fat percentage, indicators metabolic syndrome (e.g., triglycerides, HDL cholesterol, fasting blood glucose, insulin, insulin resistance (HOMA-IR)).

Language: Английский

Citations

1
Educação em saúde focado na obesidade DOI Open Access
Andréia Felipe de Oliveira Nascente, Yan Fincatto, Vanessa Machry

et al.

Published: Jan. 1, 2023

Obesity is a multifactorial disease that presents worldwide growth, its causes are mainly due to the consumption of hypercaloric foods and sedentary lifestyle.Epidemiological data show in Brazil, last 13 years, obesity increased by 72%, reaching 20.3% population 2019.This phenomenon has also been observed children.It estimated 2025, 2.3 billion adults will be overweight there 700 million obese worldwide.Given above, objective work was research on health education focused obesity.For this, an exploratory descriptive literature review carried out.It acts as way building knowledge society general, promoting people's autonomy, helping structure critical order discern need change habits, adopt healthy diet practice physical activity.In addition, investing brings direct benefits each citizen, it manages lower costs part State or plans themselves.Therefore, fundamental tool for prevention control obesity.

Language: Английский

Citations

2
МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ II СЛОЯ ЗРИТЕЛЬНОЙ ЗОНЫ КОРЫ ПРИ ПРИМЕНЕНИИ ФРУКТОЗО-ЖИРОВОЙ ДИЕТЫ DOI Open Access

Елена Юрьевна Золокотская

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

МЦНП «НОВАЯ НАУКА» МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ II СЛОЯ ЗРИТЕЛЬНОЙ

Language: Русский

Citations

0
Large-Scale Population-Based Studies of Blood Metabolome and Brain Health DOI
Zdenka Pausová, Eeva Sliz

Current topics in behavioral neurosciences, Journal Year: 2024, Volume and Issue: unknown, P. 177 - 219

Published: Jan. 1, 2024

Language: Английский

Citations

0
Population Neuroscience: Principles and Advances DOI
Tomáš Paus

Current topics in behavioral neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Deciphering the Causal Influence of BMI and related Metabolic, Inflammatory, and Cardiovascular Factors on Brain Structure: A Mendelian Randomization Study DOI
Nils Opel, Jodie N. Painter, Alexander Refisch

et al.

Published: July 11, 2024

Abstract Obesity is a highly prevalent metabolic risk factor that commonly coincides with additional metabolic, cardiovascular, and inflammatory abnormalities. has frequently been shown to affect brain physiology at multiple levels, increase the for development of neuropsychiatric disorders such as major depression dementia. Previous large-scale neuroimaging research consistently overlapping structural alterations in obesity disorders, most pronounced being lower cortical thickness frontal temporal cortex. Yet, direction association, potential causal effect on decline, remains unclear. Moreover, it imperative determine which multifaceted biological systems impacted by obesity, encompassing aspects, may be implicated link between decline. In this study, we employed univariate multivariate Mendelian randomization (MR) an instrumental variable (IV) approach clarify relationship body mass index (BMI) structure disentangle factors might underlie relationship. We found evidence influence elevated BMI thickness, prominent effects regions. furthermore concurrent association serum marker CRP visceral adipose tissue (VAT) both globally regionally across regions, largely those associated increased BMI. contrast, very few associations emerged blood pressure or markers. Our findings thus corroborate notion indicate low-grade inflammation candidate mechanism Future should aim delineate if how related decline conveys disorders.

Language: Английский

Citations

0
The Obese Brain DOI
Sara Carmo‐Silva, Clévio Nóbrega

Obesity, Journal Year: 2024, Volume and Issue: unknown, P. 9 - 37

Published: Jan. 1, 2024

Citations

0
Single Nuclei Transcriptomics Reveals Obesity-Induced Endothelial and Neurovascular Dysfunction: Implications for Cognitive Decline DOI Open Access
Dragan Milenković, Saivageethi Nuthikattu, Jennifer Norman

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11169 - 11169

Published: Oct. 17, 2024

Obesity confers risk for cardiovascular disease and vascular dementia. However, genomic alterations modulated by obesity in endothelial cells the brain their relationship to other neurovascular unit (NVU) are unknown. We performed single nuclei RNA sequencing (snRNAseq) of NVU (endothelial cells, astrocytes, microglia, neurons) from hippocampus obese (

Language: Английский

Citations

0