Nutraceuticals,
Journal Year:
2023,
Volume and Issue:
3(2), P. 250 - 261
Published: May 23, 2023
Growing
evidence
indicates
chronic
low-grade
systemic
inflammation
as
a
major
pathophysiological
mechanism
of
obesity.
Systemic
provokes
an
immune
response
in
the
brain
through
activation
microglia
that
results
development
neuroinflammation,
cellular
senescence,
and
occurrence
neurological
dysfunction.
In
efforts
to
identify
innovative
intervention
with
potential
efficacy
on
obesity
associated
complications,
our
aim
was
study
capability
dietary
supplement
Dekosilhue®
(DKS),
successfully
used
for
improving
control
body
weight,
attenuate
senescent
phenotype.
Microglia
senescence
induced
by
intermittent
stimulation
BV2
cells
LPS
500
ng/mL
every
72
h
4
h/day,
over
period
10
days.
DKS
(100
µg/mL)
treatment
reduced
ß-galactosidase
activity
expression,
formation
senescence-associated
heterochromatin
foci
levels,
increased
cell
viability
(2
folds
control).
DSK
expression
Nuclear
Factor-kB
(NF-kB)
(20%
lower
than
control),
key
molecule
involved
acquisition
secretory
phenotype
(SASP).
promoted
neuroprotective
effect
increasing
SH-SY5Y
neuronal
exposed
conditioned
medium
values
non-senescent
cells.
conclusion,
attenuated
phenotype,
showing
senotherapeutic
might
be
further
investigated
adjunctive
obesity-related
disturbances.
Professare,
Journal Year:
2023,
Volume and Issue:
unknown, P. e2971 - e2971
Published: March 16, 2023
A
obesidade
é
uma
doença
multifatorial
que
apresenta
crescimento
mundial.
As
suas
causas
são,
principalmente,
devido
ao
consumo
de
alimentos
hipercalóricos
e
sedentarismo.
Os
dados
epidemiológicos
mostram
que,
no
Brasil,
nos
últimos
13
anos,
a
sofreu
um
acréscimo
72%
alcançando
20,3%
da
população
em
2019.
Nas
crianças
também
se
tem
observado
esse
fenômeno.
Estima-se
2025,
2,3
bilhões
adultos
estejam
com
sobrepeso
existam
700
milhões
obesos,
todo
o
mundo.
Diante
do
exposto,
objetivo
trabalho
foi
pesquisar
sobre
educação
saúde
focada
na
obesidade.
Para
isso
realizada
revisão
literatura
caráter
exploratório
descritivo.
Foi
atua
como
forma
construção
conhecimento
pela
sociedade
geral,
promovendo
autonomia
das
pessoas
auxiliando
estruturação
crítico
para
poder
discernir
necessidade
mudança
hábitos,
adoção
alimentação
saudável
prática
atividade
física.
Além
disso,
investir
traz
benefícios
diretos
cada
cidadão,
consegue
ainda
baixar
custos
pública
por
parte
Estado
ou
dos
próprios
planos
saúde.
Portanto,
constitui
ferramenta
fundamental
prevenção
controle
Palavras-chave:
Obesidade.
Manejo
Educação
ABSTRACT
Obesity
is
multifactorial
disease
that
presents
worldwide
growth,
its
causes
are
mainly
due
to
the
consumption
of
hypercaloric
foods
and
sedentary
lifestyle.
Epidemiological
data
show
in
Brazil,
last
years,
obesity
increased
by
72%,
reaching
20.3%
population
This
phenomenon
has
also
been
observed
children.
It
estimated
2.3
billion
adults
will
be
overweight
there
million
obese
worldwide.
Given
above,
objective
work
was
research
on
health
education
focused
obesity.
For
this,
an
exploratory
descriptive
literature
review
carried
out.
acts
as
way
building
knowledge
society
general,
promoting
people's
autonomy,
helping
structure
critical
order
discern
need
change
habits,
adopt
healthy
diet
practice
physical
activity.
In
addition,
investing
brings
direct
benefits
each
citizen,
it
manages
lower
costs
part
State,
or
plans
themselves.
Therefore,
tool
for
prevention
control
Keywords:
Obesity.
management.
Health
education.
Current Opinion in Nephrology & Hypertension,
Journal Year:
2022,
Volume and Issue:
32(2), P. 165 - 171
Published: Dec. 23, 2022
Purpose
of
review
Transition
from
acute
kidney
injury
(AKI)
to
chronic
disease
(CKD)
is
increasingly
accepted.
Less
well
recognized,
but
supported
by
very
similar
data,
development
other
organ
systems
after
AKI.
Awareness
other-organ
sequelae
AKI
may
inform
efforts
improve
the
care
patients
Recent
findings
Stroke,
hypertension,
reproductive
risk,
dementia,
and
death
(SHReDD)
are
sequelae,
which
occur
with
increased
risk
relative
that
non-AKI
within
6
months–3
years
diagnosis,
preclinical/mechanistic
study.
Adjusted
hazard
ratios
for
these
strikingly
AKI–CKD,
ranging
1.2
3.0.
Mechanistic
studies
suggest
kidney-centric
mechanisms
including
sodium
regulation,
volume
status
renin-angiotensin
system
drivers
long-term,
extra-renal,
change.
Summary
Further
clinical
characterization
mechanistic
insight
necessary,
have
considerable
translational
impact.
Programs
screen
or
follow
post-AKI
increase
utility
if
focus
expanded
include
SHReDD
complications.
Nutraceuticals,
Journal Year:
2023,
Volume and Issue:
3(2), P. 250 - 261
Published: May 23, 2023
Growing
evidence
indicates
chronic
low-grade
systemic
inflammation
as
a
major
pathophysiological
mechanism
of
obesity.
Systemic
provokes
an
immune
response
in
the
brain
through
activation
microglia
that
results
development
neuroinflammation,
cellular
senescence,
and
occurrence
neurological
dysfunction.
In
efforts
to
identify
innovative
intervention
with
potential
efficacy
on
obesity
associated
complications,
our
aim
was
study
capability
dietary
supplement
Dekosilhue®
(DKS),
successfully
used
for
improving
control
body
weight,
attenuate
senescent
phenotype.
Microglia
senescence
induced
by
intermittent
stimulation
BV2
cells
LPS
500
ng/mL
every
72
h
4
h/day,
over
period
10
days.
DKS
(100
µg/mL)
treatment
reduced
ß-galactosidase
activity
expression,
formation
senescence-associated
heterochromatin
foci
levels,
increased
cell
viability
(2
folds
control).
DSK
expression
Nuclear
Factor-kB
(NF-kB)
(20%
lower
than
control),
key
molecule
involved
acquisition
secretory
phenotype
(SASP).
promoted
neuroprotective
effect
increasing
SH-SY5Y
neuronal
exposed
conditioned
medium
values
non-senescent
cells.
conclusion,
attenuated
phenotype,
showing
senotherapeutic
might
be
further
investigated
adjunctive
obesity-related
disturbances.
