Ibuprofen: Toxicology and Biodegradation of an Emerging Contaminant
Molecules,
Journal Year:
2023,
Volume and Issue:
28(5), P. 2097 - 2097
Published: Feb. 23, 2023
The
anti-inflammatory
drug
ibuprofen
is
considered
to
be
an
emerging
contaminant
because
of
its
presence
in
different
environments
(from
water
bodies
soils)
at
concentrations
with
adverse
effects
on
aquatic
organisms
due
cytotoxic
and
genotoxic
damage,
high
oxidative
cell
stress,
detrimental
growth,
reproduction,
behavior.
Because
human
consumption
rate
low
environmental
degradation
rate,
represents
problem.
Ibuprofen
enters
the
environment
from
sources
accumulates
natural
matrices.
problem
drugs,
particularly
ibuprofen,
as
contaminants
complicated
few
strategies
consider
them
or
apply
successful
technologies
remove
a
controlled
efficient
manner.
In
several
countries,
ibuprofen’s
entry
into
unattended
contamination
It
concern
for
our
health
system
that
requires
more
attention.
Due
physicochemical
characteristics,
difficult
by
microorganisms.
There
are
experimental
studies
currently
focused
drugs
potential
contaminants.
However,
these
insufficient
address
this
ecological
issue
worldwide.
This
review
focuses
deepening
updating
information
concerning
using
bacteria
biodegradation
alternative
technology.
Language: Английский
Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin
Veterinární Medicína,
Journal Year:
2025,
Volume and Issue:
70(1), P. 20 - 29
Published: Jan. 20, 2025
The
present
study
aimed
to
evaluate
the
biochemical
and
antioxidant
responses
of
common
carp
after
exposure
antiepileptic
analgesic
drug
gabapentin
at
concentrations
0.1,
1,
10,
100
μg/l
for
4
weeks.
highest
two
resulted
in
significant
changes
plasma
indices
such
as
glucose
(only
group
μg/l),
alanine
aminotransferase
(ALT),
lactate
dehydrogenase
(LDH),
lipase,
creatine
kinase
(CK),
amylase
well
butyrylcholinesterase
(BChE).
Similar
trends
were
found
both
groups
exposed
environmentally
relevant
(i.e.,
0.1
1
μg/l).
In
addition,
a
increase
ferric-reducing
power
was
noted
all
treated
groups.
Numerous
enzymes,
superoxide
dismutase,
catalase,
glutathione-S-transferase,
lipid
peroxidation,
observed
especially
caudal
kidney
μg/l.
Significant
findings
also
confirmed
an
concentration
(1
with
decrease
dismutase
gill
increased
lipoperoxidation
kidney.
Our
research
shows
that
subchronic
may
pose
risk
non-target
aquatic
organisms,
disruption
metabolic
pathways
or
induction
oxidative
stress,
even
concentrations.
Language: Английский
Toward Real-Time Animal Tracking with Integrated Stimulus Control for Automated Conditioning in Aquatic Eco-Neurotoxicology
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(48), P. 19453 - 19462
Published: Nov. 13, 2023
Aquatic
eco-neurotoxicology
is
an
emerging
field
that
requires
new
analytical
systems
to
study
the
effects
of
pollutants
on
animal
behaviors.
This
especially
true
if
we
are
gain
insights
into
one
least
studied
aspects:
potential
perturbations
neurotoxicants
can
have
cognitive
The
paucity
experimental
data
partly
caused
by
a
lack
low-cost
technologies
for
analysis
higher-level
neurological
functions
(e.g.,
associative
learning)
in
small
aquatic
organisms.
Here,
present
proof-of-concept
prototype
utilizes
real-time
tracking
software
on-the-fly
video
and
closed-loop,
external
hardware
communications
deliver
stimuli
based
specific
behaviors
organisms,
spanning
three
phyla:
chordates
(fish,
frog),
platyhelminthes
(flatworm),
arthropods
(crustacean).
system's
open-source
features
intuitive
graphical
user
interface
advanced
adaptive
threshold-based
image
segmentation
precise
detection.
We
demonstrate
precision
across
multiple
species
with
varying
modes
locomotion.
presented
technology
interfaces
easily
such
as
Arduino
microcontroller
family
closed-loop
control.
system
has
future
applications
eco-neurotoxicology,
where
it
could
enable
opportunities
research
diverse
model
Language: Английский