Epigenetic modifications in solid tumor metastasis in people of African ancestry DOI Creative Commons
Elijah Kolawole Oladipo,

Seun Elijah Olufemi,

Daniel Adewole Adediran

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 21, 2024

This review focuses on the critical role of epigenetic modifications in solid tumor metastasis, particularly people African ancestry. Epigenetic alterations, such as DNA methylation, histone modifications, alterations non-coding RNAs, and mRNA significantly influence gene expression, contributing to cancer development progression. Despite primary focus populations European, American, Asian descent most research, this work emphasizes importance studying unique genetic landscapes for a more inclusive approach understanding treating cancer. Insights from have potential pave way effective, tailored treatments, provide richer resource progression metastasis. Specific was placed methylation including how these contribute regulation suppressor genes oncogenes, cellular pathways signaling, interact with immune system. Moreover, elaborates epigenetic-targeted therapeutic strategies current advances field, highlighting promising applications therapies improving outcomes ancestry disproportionately affected by certain types Nevertheless, acknowledges challenges that lie ahead, under-representation genomic epigenomic studies technical complications associated detecting subtle modifications. Emphasis is necessity research practices, robust sensitive methods interpreting changes, interplay between variations. The concludes an optimistic outlook future People ancestry, urging concerted efforts researchers, clinicians, funding agencies, policymakers extend benefits all populations.

Language: Английский

Insights into DNMT1 and programmed cell death in diseases DOI Open Access
Lan Yan, Qi Geng,

Zhiwen Cao

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115753 - 115753

Published: Oct. 21, 2023

DNMT1 (DNA methyltransferase 1) is the predominant member of DNMT family and most abundant in various cell types. It functions as a maintenance involved diseases, including cancer nervous system diseases. Programmed death (PCD) fundamental mechanism that regulates proliferation maintains development homeostasis multicellular organisms. plays regulatory role types PCD, apoptosis, autophagy, necroptosis, ferroptosis, others. closely associated with diseases by regulating key genes pathways caspase 3/7 activities Beclin 1, LC3, some autophagy-related proteins glutathione peroxidase 4 (GPX4) nuclear receptor coactivator (NCOA4) receptor-interacting protein kinase 1-receptor-interacting 3-mixed lineage domain-like (RIPK1-RIPK3-MLKL) necroptosis. Our study summarizes relationship between different PCD discusses potential common hub multiple offering perspective for therapeutic approaches disease.

Language: Английский

Citations

21
Targeting DNA methyltransferases for cancer therapy DOI
Kaiyue Wang,

Zhangxu He,

Gang Jin

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 151, P. 107652 - 107652

Published: July 15, 2024

Language: Английский

Citations

8
Role of Epigenetics for the Efficacy of Cisplatin DOI Open Access

Tatjana Lumpp,

Sandra Stößer,

Franziska Fischer

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1130 - 1130

Published: Jan. 17, 2024

The clinical utility of the chemotherapeutic agent cisplatin is restricted by cancer drug resistance, which either intrinsic to tumor or acquired during therapy. Epigenetics increasingly recognized as a factor contributing resistance and hence influences efficacy outcomes. In particular, epigenetics regulates gene expression without changing DNA sequence. Common types epigenetic modifications linked chemoresistance are methylation, histone modification, non-coding RNAs. This review provides an overview current findings various related in cell lines vitro samples. Furthermore, it discusses whether alterations might be used predictors platinum response order prevent avoidable side effects patients with resistant malignancies. addition, targeting therapies described possible strategy render cells more susceptible drugs.

Language: Английский

Citations

6
Research progress and applications of epigenetic biomarkers in cancer DOI Creative Commons
Jianjun Gao, Wujiang Shi,

Jiangang Wang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 12, 2024

Epigenetic changes are heritable in gene expression without the nucleotide sequence of genes. play an important role development cancer and process malignancy metastasis. Previous studies have shown that abnormal epigenetic can be used as biomarkers for disease status prediction. The reversibility controllability modification also provide new strategies early prevention treatment. In addition, corresponding drug has reached clinical stage. this paper, we will discuss recent progress application tumor from three perspectives: DNA methylation, non-coding RNA, histone modification, order to opportunities additional research applications.

Language: Английский

Citations

5
ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma DOI Creative Commons
Tushuai Li, Longjiang Xu,

Zhe Wei

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Nov. 18, 2023

Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system. Angiogenesis main contributing factor for tumorigenesis. E74-like transcription 5 (ELF5) has been verified to participate in progression different cancers and can regulate angiogenesis. This study was aimed explore functions ELF5 RCC.Bioinformatics tools were used predict expression RCC. RT-qPCR applied testing RCC cells. Cell behaviors evaluated by colony formation, CCK-8, transwell assays. The tube formation assay determining Methylation-specific PCR (MSP) utilized measuring methylation level ChIP luciferase reporter assays assessing binding ubiquitin-specific protease 3 (USP3). Co-IP GST pull-down detecting interaction WD40 tetratricopeptide repeats 1 (WDTC1) USP3. Ubiquitination WDTC1 determined ubiquitination assay.ELF5 lowly expressed cells tissues. High notably suppressed proliferative, migratory, invasive capabilities, inhibited growth mice overexpression. highly methylated samples, DNA methyltransferases (DNMTs) promote hypermethylation further proved transcriptionally activate USP3 Moreover, ubiquitination. USP3-mediated stabilization. Additionally, silencing reversed overexpression on progression.Downregulation due inhibits development though USP3/WDTC1axis

Language: Английский

Citations

10
A Review of Advanced Cutaneous Melanoma Therapies and Their Mechanisms, from Immunotherapies to Lysine Histone Methyl Transferase Inhibitors DOI Open Access
Renato Santos de Oliveira Filho, Daniel Arcuschin de Oliveira,

Melissa Maeda Nisimoto

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(24), P. 5751 - 5751

Published: Dec. 8, 2023

Advanced cutaneous melanoma is considered to be the most aggressive type of skin cancer and has variable rates treatment response. Currently, there are some classes immunotherapy target therapies for its treatment. Immunotherapy can inhibit tumor growth recurrence by triggering host's immune system, whereas targeted therapy inhibits specific molecules or signaling pathways. However, responses these treatments highly heterogeneous, patients develop resistance. Epigenomics (DNA/histone modifications) contribute initiation progression. Epigenetic alterations divided into four levels gene expression regulation: DNA methylation, histone modification, chromatin remodeling, non-coding RNA regulation. Deregulation lysine methyltransferase enzymes associated with initiation, invasion, development metastases, changes in microenvironment, drug The study (KMT) nicotinamide N-methyltransferase (NNMT) inhibitors important understanding epigenetic mechanisms biological processes. In addition therapy, research KMT NNMT ongoing. Many studies exploring therapeutic implications possible side effects compounds, their adjuvant potential approved current therapies. Importantly, as any development, safety, efficacy, specificity crucial considerations when developing clinical applications. Thus, this review article presents recently available those advanced therapy.

Language: Английский

Citations

10
Epigenetic Regulation of EMP/EMT-Dependent Fibrosis DOI Open Access
Margherita Sisto, Sabrina Lisi

Published: Jan. 3, 2024

Fibrosis represents a process characterized by excessive deposition of extracellular matrix (ECM) proteins. It often the evolution pathological conditions, causes organ failure, and can, in extreme cases, compromises functionality organs to point causing death. In recent years, considerable efforts have been made understand molecular mechanisms underlying fibrotic identify possible therapeutic strategies. Great interest has aroused discovery association between epithelial mesenchymal plasticity (EMP), particular transition (EMT), fibrogenesis, which led identification complex closely interconnected with each other, could explain EMT-dependent fibrosis. However, result remains unsatisfactory from view. advances epigenetics, is based on chromatin remodeling through various histone modifications or intervention non-coding RNAs (ncRNAs), provided more information process, this represent promising path forward for innovative strategies review, we summarize current research epigenetic involved fibrosis, focus regulation EMP/EMT-dependent

Language: Английский

Citations

4
Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis DOI Creative Commons

Fanhao Wei,

Binjia Ruan,

Jian Dong

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Diabetic osteoporosis (DOP) is an insidious complication of diabetes with limited therapeutic options. DOP pathologically associated various types regulated cell death, but the precise role ferroptosis in process remains poorly understood. Asperosaponin VI (AVI), known for its clinical efficacy treating bone fractures and osteoporosis, may exert osteoprotective effects through mechanisms involving ferroptosis, however this has not been established.

Language: Английский

Citations

3
Epigenetics in Skin Homeostasis and Ageing DOI Creative Commons
Iasonas Dermitzakis, Stella Aikaterini Kyriakoudi,

Sofia Chatzianagnosti

et al.

Epigenomes, Journal Year: 2025, Volume and Issue: 9(1), P. 3 - 3

Published: Jan. 9, 2025

The skin, the largest organ of human body, plays numerous essential roles, including protection against environmental hazards and regulation body temperature. processes skin homeostasis ageing are complex influenced by many factors, with epigenetic mechanisms being particularly significant. Epigenetics refers to gene expression without altering underlying DNA sequence. dynamic nature characterized constant cellular turnover responsiveness stimuli, requires precise activity control. This control is largely mediated modifications such as methylation, histone modification, non-coding RNAs. present review endeavours provide a comprehensive exploration elucidation role in regulating ageing. By integrating our current knowledge latest advancements dermatological research, we can gain deeper comprehension regulatory networks that govern biology. Understanding these also presents promising avenues for therapeutic interventions aimed at improving health mitigating age-related conditions.

Language: Английский

Citations

0
Embryo vitrification impacts learning and spatial memory by altering the imprinting genes expression level in the mouse offspring’ hippocampus DOI Creative Commons

Samira Hosseini,

Sara Hosseini, Hadi Aligholi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 13, 2025

The safety and impact of embryo vitrification as a more reliable approach for cryopreservation in assisted reproductive techniques (ARTs) on the nervous system is uncertain. This study was aimed to investigate expression level imprinting genes hippocampus offspring derived from vitrified transfer. 2-day-old three experimental groups included (blastocysts embryos), sham (the embryos at blastocyst stage obtained through vitro fertilization (IVF)) control removed molecular, histological behavioral analysis. There no statistically noteworthy difference survival, cleavage blastocysts rate between groups. Dnmt1, Dnmt3a, 3b Igf2 upregulated group compared gene Meg3 declined dramatically intensity DNA methylation CpG island significantly elevated group. A notable disparity observed quantity dark neurons offspring, spatial learning memory abilities According these results, may alters brain tissue disturbs genomic imprinting, neuron formation memory.

Language: Английский

Citations

0