Role of TRAP1 Protein in the Development and Progression of Glioblastoma DOI Creative Commons
Ilgiz Gareev, A. S. Yasinskaya, S. A. Roumiantsev

et al.

Creative Surgery and Oncology, Journal Year: 2024, Volume and Issue: 14(4), P. 369 - 381

Published: Dec. 28, 2024

Glioblastoma is recognized as the most aggressive type of primary brain tumor. Despite recent advances in understanding molecular mechanisms involved biology glioblastoma, patient survival rates remain disappointing, primarily due to lack effective treatment options. Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member heat shock 90 (Hsp90) family, refers predominantly localized mitochondria that regulates both cellular metabolic reprogramming and mitochondrial apoptosis. This highly expressed several types tumors, including colorectal cancer, breast prostate lung often associated with drug resistance. However, TRAP1 also downregulated certain cancers such ovarian bladder renal where its lower expression correlates poorer prognoses chemoresistance. The role lies enhancing or suppressing oxidative phosphorylation, impact regulation on tumor development progression being matter ongoing debate. These observations prompt further investigation into responsible for dual an oncogene suppressor specific particularly glioblastoma. present study reviews glioblastoma discusses potential targeting novel therapeutic approach against tumors.

Language: Английский

Unraveling the impact of miR-21 on apoptosis regulation in glioblastoma DOI
Mohammad Arshad Javed Shaikh, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155121 - 155121

Published: Jan. 10, 2024

Language: Английский

Citations

21
Deciphering glioma epitranscriptome: focus on RNA modifications DOI
Christina Piperi,

Mariam Markouli,

Antonios N. Gargalionis

et al.

Oncogene, Journal Year: 2023, Volume and Issue: 42(28), P. 2197 - 2206

Published: June 15, 2023

Language: Английский

Citations

12
The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer DOI Creative Commons

Qiu Li,

Shourong Wu, Lei Zhang

et al.

Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101567 - 101567

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advances in brain epitranscriptomics research and translational opportunities DOI
Feng Zhang, V. V. Ignatova, Guo‐li Ming

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(2), P. 449 - 463

Published: Dec. 20, 2023

Language: Английский

Citations

6
Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system DOI Creative Commons

Antonia Barry,

Sabrina F. Samuel,

Inès Hosni

et al.

Lab on a Chip, Journal Year: 2023, Volume and Issue: 23(11), P. 2664 - 2682

Published: Jan. 1, 2023

Treatment of human brain tumour biopsies, maintained on-chip, with type I PRMT inhibitors leads to apoptosis through changes in gene expression and RNA processing, mediated by cross-talk II PRMT.

Language: Английский

Citations

5
The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses DOI Creative Commons
Christian Ramsoomair, Michele Ceccarelli, John D. Heiss

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Dec. 9, 2023

Abstract Glioblastoma (GBM) comprises 45.6% of all primary malignant brain cancers and is one the most common aggressive intracranial tumors in adults. Intratumoral heterogeneity with a wide range proteomic, genetic, epigenetic dysregulation contributes to treatment resistance poor prognosis, thus demanding novel therapeutic approaches. To date, numerous clinical trials have been developed target proteome epigenome high-grade gliomas promising results. However, studying RNA modifications, or epitranscriptomics, new frontier within neuro-oncology. epitranscriptomics was discovered 1970s, but last decade, extent modification mRNA various non-coding RNAs has emerged implicated transposable element activation many other oncogenic processes tumor microenvironment. This review provides background information discusses potential agents modulating gliomas. A particular emphasis will be placed on how combination therapies that include immune targeting hERV-mediated viral mimicry could improve GBM.

Language: Английский

Citations

5
Dual-space disentangled-multimodal network (DDM-net) for glioma diagnosis and prognosis with incomplete pathology and genomic data DOI
Lu Qiu, Lu Zhao, Wangyuan Zhao

et al.

Physics in Medicine and Biology, Journal Year: 2024, Volume and Issue: 69(8), P. 085028 - 085028

Published: April 10, 2024

Abstract Objective . Effective fusion of histology slides and molecular profiles from genomic data has shown great potential in the diagnosis prognosis gliomas. However, it remains challenging to explicitly utilize consistent-complementary information among different modalities create comprehensive representations patients. Additionally, existing researches mainly focus on complete multi-modality usually fail construct robust models for incomplete samples. Approach In this paper, we propose a dual-space disentangled-multimodal network (DDM-net) glioma prognosis. DDM-net disentangles latent features generated by two separate variational autoencoders (VAEs) into common specific components through disentangled approach, facilitating construction More importantly, imputes unavailable modality feature space, making Main results We evaluated our approach TCGA-GBMLGG dataset grading survival analysis tasks. Experimental demonstrate that proposed method achieves superior performance compared state-of-the-art methods, with competitive AUC 0.952 C-index 0.768. Significance The model may help clinical understanding gliomas can serve as an effective multimodal data. is capable handling samples, less constrained limitations.

Language: Английский

Citations

1
The association of sperm BAX and BCL-2 gene expression with reproductive outcome in Oligoasthenoteratozoospermia cases undergoing intracytoplasmic sperm injection: A case-control study DOI Creative Commons

Fatemeh Babaei,

Maryam Khoshsokhan Muzaffar,

Rahil Jannatifar

et al.

International Journal of Reproductive BioMedicine (IJRM), Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

The B-cell lymphoma 2 (

Language: Английский

Citations

0
Role of TRAP1 Protein in the Development and Progression of Glioblastoma DOI Creative Commons
Ilgiz Gareev, A. S. Yasinskaya, S. A. Roumiantsev

et al.

Creative Surgery and Oncology, Journal Year: 2024, Volume and Issue: 14(4), P. 369 - 381

Published: Dec. 28, 2024

Glioblastoma is recognized as the most aggressive type of primary brain tumor. Despite recent advances in understanding molecular mechanisms involved biology glioblastoma, patient survival rates remain disappointing, primarily due to lack effective treatment options. Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member heat shock 90 (Hsp90) family, refers predominantly localized mitochondria that regulates both cellular metabolic reprogramming and mitochondrial apoptosis. This highly expressed several types tumors, including colorectal cancer, breast prostate lung often associated with drug resistance. However, TRAP1 also downregulated certain cancers such ovarian bladder renal where its lower expression correlates poorer prognoses chemoresistance. The role lies enhancing or suppressing oxidative phosphorylation, impact regulation on tumor development progression being matter ongoing debate. These observations prompt further investigation into responsible for dual an oncogene suppressor specific particularly glioblastoma. present study reviews glioblastoma discusses potential targeting novel therapeutic approach against tumors.

Language: Английский

Citations

0