Alcohol and the mechanisms of liver disease

Journal of Gastroenterology and Hepatology, Journal Year: 2023, Volume and Issue: 38(8), P. 1233 - 1240

Published: July 9, 2023

Abstract Alcoholic liver disease (ALD), which is a leading cause of morbidity and mortality worldwide, covers large spectrum injuries ranging from simple steatosis to steatohepatitis, advanced fibrosis, cirrhosis, hepatocellular carcinoma. The pathogenesis ALD includes genetic epigenetic alterations, oxidative stress, acetaldehyde‐mediated toxicity cytokine chemokine‐induced inflammation, metabolic reprogramming, immune damage, dysbiosis the gut microbiota. This review discusses progress in molecular mechanism ALD, could provide evidence for further research on potential therapeutic strategies targeting these pathways.

Language: Английский

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Pathogenesis of Hepatocellular Carcinoma: The Interplay of Apoptosis and Autophagy

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1166 - 1166

Published: April 13, 2023

The pathogenesis of hepatocellular carcinoma (HCC) is a multifactorial process that has not yet been fully investigated. Autophagy and apoptosis are two important cellular pathways critical for cell survival or death. balance between autophagy regulates liver turnover maintains intracellular homeostasis. However, the often dysregulated in many cancers, including HCC. may be either independent parallel one influence other. inhibit promote apoptosis, thus regulating fate cancer cells. In this review, concise overview HCC presented, with emphasis on new developments, role endoplasmic reticulum stress, implication microRNAs gut microbiota. characteristics associated specific disease also described brief description provided. initiation, progress metastatic potential reviewed experimental evidence indicating an interplay extensively analyzed. ferroptosis, recently pathway regulated death, presented. Finally, therapeutic implications drug resistance examined.

Language: Английский

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Effect of Tetrastigma hemsleyanum leaves and Extract supplementation on liver metabolomics and the gut microbiota in alcohol-induced liver injury

Food Bioscience, Journal Year: 2024, Volume and Issue: 58, P. 103617 - 103617

Published: Jan. 20, 2024

Language: Английский

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Mallotucin D, a Clerodane Diterpenoid from Croton crassifolius, Suppresses HepG2 Cell Growth via Inducing Autophagic Cell Death and Pyroptosis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 14217 - 14217

Published: Nov. 17, 2022

Hepatocellular carcinoma (HCC) is a major subtype of primary liver cancer with high mortality rate. Pyroptosis and autophagy are crucial processes in the pathophysiology HCC. Searching for efficient drugs targeting pyroptosis lower toxicity useful HCC treatment. Mallotucin D (MLD), clerodane diterpenoid from Croton crassifolius, has not been previously reported its anticancer effects This study aims to evaluate inhibitory MLD explore underlying mechanism. We found that cell proliferation, DNA synthesis, colony formation HepG2 cells angiogenesis HUVECs were all greatly inhibited by MLD. caused mitochondrial damage decreased TOM20 expression membrane potential, inducing ROS overproduction. Moreover, promoted cytochrome C mitochondria into cytoplasm, leading cleavage caspase-9 caspase-3 GSDMD-related pyroptosis. In addition, we revealed activated mitophagy inhibiting PI3K/AKT/mTOR pathway. Using ROS-scavenging reagent NAC, activation on pyroptosis- autophagy-related pathways inhibited. xenograft model, effectively tumor growth without detectable toxicities normal tissue. conclusion, could be developed as candidate drug treatment via promoting mitochondrial-related production.

Language: Английский

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Novel NIR fluorescent probe based on BODIPY for diagnosis and treatment evaluation of alcoholic liver disease via visualizing HClO fluctuation

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 328, P. 125497 - 125497

Published: Nov. 26, 2024

Language: Английский

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Comparison of Surgical Resection and Percutaneous Ultrasonographic Guided Radiofrequency Ablation for Initial Recurrence of Hepatocellular Carcinoma in Early Stage following Curative Treatment

Cancers, Journal Year: 2022, Volume and Issue: 14(22), P. 5524 - 5524

Published: Nov. 10, 2022

Background/Aim: The SURF trial showed that surgical resection (SR) and percutaneous ultrasonographic guided radiofrequency ablation (RFA) had equal therapeutic effects for small hepatocellular carcinoma (HCC). However, consensus regarding which treatment is appropriate initial recurrent early-stage HCC remains lacking. This study aimed to elucidate efficacy differences between SR RFA HCC. Materials/Methods: From 2000 2021, 371 patients with (≤3 cm, ≤3 nodules) after undergoing curative or were enrolled (median age 72 years; males 269; Child−Pugh A:B, n = 328:43; SR:RFA, 36:335). Recurrence-free survival (RFS) overall (OS) retrospectively evaluated. Results: Although the median albumin−bilirubin (ALBI) score was better in than group (−2.90 vs. −2.50, p < 0.01), there no significant them regard RFS 28.1 months, 95% CI 23.4−50.0 22.1 19.3−26.2; 0.34), OS (78.9 49.3—not applicable 71.2 months CI, 61.8−84.7; 0.337), complications (8.3% 9.3%; 1.0). In sub-analysis according ALBI grade revealed groups (ALBI 1/2 28.2/17.5 24.0/23.4 months; 0.881/0684 78.9/58.9 115.3/52.6 0.651/0.578, respectively). Conclusion: retrospective found recurrence of treatment. These results showing confirm findings trial.

Language: Английский

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Potential of African plants and their derived phytochemicals against hepatocellular carcinoma

Advances in botanical research, Journal Year: 2024, Volume and Issue: unknown, P. 409 - 458

Published: Jan. 1, 2024

Language: Английский

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A near-infrared ONOO−-activated fluorescent probe for real-time visualizing of alcoholic liver disease

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140805 - 140805

Published: Nov. 1, 2024

Language: Английский

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Self-Reported Nutritional Status and Breakfast Characterization in Latin American University Students

Journal of the American Nutrition Association, Journal Year: 2023, Volume and Issue: 43(3), P. 252 - 260

Published: Oct. 6, 2023

AbstractObjective To associate breakfast consumption frequency with self-reported nutritional status and dietary patterns of Latin American university students by human development.Material methods This was a cross-sectional, multicenter observational study. University from 11 countries (Argentina, Chile, Colombia, Costa Rica, Ecuador, Guatemala, Mexico, Peru, Paraguay, Panama Uruguay) were invited to participate answering an online self-administered questionnaire on food sociodemographic indicators, associations investigated using logistic regression.Results The regression analysis showed significant between the crude model, models 2 3 in very high upper-middle/high development. However, after adjustment most comprehensive association is no longer statistically significant. In fully adjusted model variables, relationship observed both healthy unhealthy patterns. Specifically, who typically consume exhibit greater oatmeal fruits, as well healthier dinner choices. Conversely, they lower fast food, sugary drinks, juices. particular, highly developed countries, along mentioned foods, dairy linked positive way, while alcohol negatively associated.Conclusion eat regular basis maintain diet comparison those do not, irrespective their country's level development.Keywords: Breakfastuniversity studentsnutritional Disclosure statementNo potential conflict interest reported author(s).Data availability statementData are available upon request principal investigator.Additional informationFundingThis study self-financed.

Language: Английский

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Silencing of keratin 15 impairs viability and mobility while facilitating the doxorubicin chemosensitivity by inactivating the β‑catenin pathway in liver cancer

Oncology Letters, Journal Year: 2023, Volume and Issue: 26(4)

Published: Aug. 30, 2023

Keratin 15 (KRT15) regulates the invasion as well stemness and is associated with tumor size metastasis of several gastrointestinal cancers apart from liver cancer. The present study aimed to explore effect KRT15 knockdown on cancer malignant behaviors its interaction β-catenin pathway. Small interfering (si)-KRT15 si-negative control (NC) were transfected into cell lines, followed by addition or not CHIR-99021 (a agonist). Cell viability, invasion, apoptosis, half maximal inhibitory concentration (IC50) value doxorubicin (Dox) then assessed. illustrated that gene protein expression levels upregulated in most lines (Huh7, PLC, Hep3B HepG2) compared normal line THLE-2. si-KRT15 reduced viability invasive count while promoting apoptosis rate Huh7 HepG2 cells. In addition, also IC50 Dox. Furthermore, inactivated pathway reflected β-catenin, cyclin D1 c-Myc Subsequently, treatment increased reducing Concurrently, Dox was increased. Notably, attenuated mediating aforementioned chemosensitivity. conclusion, suppressed mobility but facilitated chemosensitivity via inactivating cancer, suggesting potential a target for treatment.

Language: Английский

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