Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Applied Microbiology and Biotechnology, Journal Year: 2023, Volume and Issue: 107(4), P. 1039 - 1061

Published: Jan. 13, 2023

Language: Английский

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Copper oxide nanoparticles: In vitro and in vivo toxicity, mechanisms of action and factors influencing their toxicology

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2023, Volume and Issue: 271, P. 109682 - 109682

Published: June 15, 2023

Language: Английский

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Progress in the development of copper oxide-based materials for electrochemical water splitting

International Journal of Hydrogen Energy, Journal Year: 2024, Volume and Issue: 62, P. 209 - 227

Published: March 12, 2024

Language: Английский

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Simultaneous Protonation and Metalation of a Porphyrin Covalent Organic Framework Enhance Photodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(24), P. 16609 - 16618

Published: June 5, 2024

Covalent organic frameworks (COFs) have been explored for photodynamic therapy (PDT) of cancer, but their antitumor efficacy is limited by excited state quenching and low reactive oxygen species generation efficiency. Herein, we report a simultaneous protonation metalation strategy to significantly enhance the PDT nanoscale two-dimensional imine-linked porphyrin-COF. The neutral unmetalated porphyrin-COF (Ptp) protonated metalated (Ptp-Fe) were synthesized via imine condensation between 5,10,15,20-tetrakis(4-aminophenyl)porphyrin terephthalaldehyde in absence presence ferric chloride, respectively. chloride generated both doubly Fe3+-coordinated porphyrin units, which red-shifted increased Q-band absorption disrupted exciton migration prevent quenching, Under light irradiation, rapid energy transfer from porphyrins Ptp-Fe enabled 1O2 hydroxyl radical type II I processes. also catalyzed conversion hydrogen peroxide hydroxy through photoenhanced Fenton-like reaction under slightly acidic conditions illumination. As result, Ptp-Fe-mediated exhibited much higher cytotoxicity than Ptp-mediated on CT26 4T1 cancer cells. afforded potent subcutaneous murine colon orthotopic triple-negative breast tumors prevented metastasis lungs. This work underscores role fine-tuning molecular structures COFs enhancing efficacy.

Language: Английский

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Application of Fourier Transform Infrared (FTIR) Spectroscopy in Characterization of Green Synthesized Nanoparticles

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 684 - 684

Published: Feb. 4, 2025

The fundamental principle of Fourier Transform Infrared (FTIR) spectroscopy is based on the vibration and rotation atoms, it has become a universal widely used spectral methodology for detection internal molecular structures in diverse range fields. A considerable number review articles pertaining to applications FTIR have been published recent years. Nevertheless, comprehensive summary application nanoparticles’ (NPs’) green synthesis yet be presented. In present paper, we propose series case studies that demonstrate analysis metal oxide NPs synthesized using processes. Furthermore, presented position functional group bands spectra are responsible reduction, capping stabilization NPs. this review, explore advantages limitations methodologies overcoming these challenges. We also potential solutions complex spectra. intended serve as compendium information researchers engaged field NPs, utilizing research tool.

Language: Английский

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Tryptophan capped gold–silver bimetallic nanoclusters-based turn-off fluorescence sensor for the determination of histamine

Talanta, Journal Year: 2023, Volume and Issue: 256, P. 124321 - 124321

Published: Jan. 30, 2023

Language: Английский

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The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activities

Green Chemistry Letters and Reviews, Journal Year: 2023, Volume and Issue: 16(1)

Published: Jan. 2, 2023

This study aims to biosynthesize zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and investigate their biological activities. UV–Vis Spectroscopy, FT-IR, SEM TEM were used for characterization. The antioxidant properties determined H2O2, NO, ABTS, FRAP DPPH scavenging assays. For anti-inflammatory activities, membrane stabilization, albumin denaturation proteinase inhibitory activity assayed. antibacterial effect was tested well diffusion method. Statistical analyses done ANOVA. Synthesized showed an intensity peak at 378 nm in Spectroscopy. FT-IR shows the presence O-H stretching, C = bending, bending C–N stretching functional groups stabilizing action plant extract on surface nanoparticles. NPs shown be spherical by analysis, sizes 100 analysis. ZnO compared ascorbic acid standard significant potential excellent with synthesized performing better stabilization. Clinical pathogens inhibited when Cefuroxime, a drug. These efficient activities could utilized several applications.

Language: Английский

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MoO3 nanoplates reinforced the structural, electrical, mechanical, and antibacterial characteristics of polyvinyl pyrrolidone/sodium alginate polymer blend for optoelectronics and biological applications

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127894 - 127894

Published: Nov. 4, 2023

Language: Английский

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Activities against Lung Cancer of Biosynthesized Silver Nanoparticles: A Review

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 389 - 389

Published: Jan. 28, 2023

Nanomedicine is an interdisciplinary field where nanostructured objects are applied to treat or diagnose disease. Nanoparticles (NPs) a special class of materials at nanometric scale that can be prepared from lipids, polymers, noble metals through bottom-up approaches. Biological synthesis reliable, sustainable, and non-toxic method uses phytochemicals, microorganisms, enzymes induce the reduction metal ions into NPs. Silver (Ag) NPs exhibit potent therapeutic properties exploited overcome limitations current treatment modalities for human health issues such as lung cancer (LC). Here, we review preparation AgNPs using biological their application against LC in vitro vivo models. An overview staging, diagnosis, genetic mutations, LC, well its main subtypes, presented. A summary reaction mechanisms microbial cell cultures, plant extracts, amino acids included. The use capping agents biosynthesis with anticancer activity also detailed. history activities metal-based nanostructures synthesized gold, copper, palladium, platinum considered. possible models covered. Our perspective about future nanomedicine added.

Language: Английский

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Green synthesis of silver nanoparticle prepared with Ocimum species and assessment of anticancer potential

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 22, 2024

Abstract Silver nanoparticles (AgNPs) have gained much attention due to their unique physical, and chemical properties. Integration of phytochemicals in nanoformulation might higher applicability healthcare. Current work demonstrates the synthesis green AgNPs with O. gratissimum (gr-AgNPs) tenuiflorum (te-AgNPs) americanum (am-AgNPs) followed by an evaluation antimicrobial anticancer SEM analysis revealed spherical-shaped particles average particle sizes 69.0 ± 5 nm for te-AgNPs, 46.9 9 gr-AgNPs, 58.5 18.7 am-AgNPs a polydispersity index below 0.4. The synthesized effectively inhibited Klebsiella pneumonia , Escherichia coli Staphylococcus aureus, Aspergillus niger, Candida albicans 23 1.58 mm, 20 1.68 22 1.80 26 1.85 1.40 zone inhibition respectively . Synthesized also induced apoptotic cell death MCF-7 concentration-dependent manner. IC 50 values am-AgNPs, gr-AgNPs were 14.78 0.89 µg, 18.04 0.63 15.41 0.37 µg which suggested that most effective against cancer. At dose size (20 µg) equally commercial standard Doxorubicin (DOX). In comparison te-AgNPs vitro effects. reported Ocimum its properties profile (GCMS) compared it earlier species. activity microbial pathogens selected cancer cells clearly depicted these species distinct variations activity. results emphasized on potential biogenic silver healthcare but before formulation products, detailed is required human animal models.

Language: Английский

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