International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10316 - 10316
Published: June 19, 2023
Vitamin D, often referred to as the "sunshine nutrient", has gained considerable attention in recent years due its multifaceted impact on health and disease [...].
Language: Английский
Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 672 - 672
Published: Feb. 13, 2025
Background/Objectives: Given the crucial health benefits of vitamin D, addressing severe deficiencies is a pressing medical concern. This study aimed to evaluate effectiveness and safety two new weekly doses calcifediol (100 µg 125 µg) for long-term management in patients with D deficiency, defined as plasma 25(OH)D levels ≤10 ng/mL. Methods: was randomized, two-cohort, controlled, double-blind, multicentre phase II-III trial. Subjects were randomized 2:2:1 100 µg, or placebo. The primary endpoint proportion achieving ≥20 ng/mL and/or ≥30 by week 16. Results: A total 276 (mean age: 55.2 years, SD 15.42) randomized. By 16, 92.3% 91.8% groups, respectively, reached ng/mL, compared 7.3% placebo group. Levels achieved 49% 76.4% (125 participants, none Calcifediol demonstrated superior efficacy at all response time points (p < 0.0001). Plasma concentrations increased 24 remained stable. incidence adverse events comparable across groups. Conclusions: dose demonstrates best profile tolerability, providing reliable solution maintaining adequate deficiency.
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: Dec. 20, 2022
Observational studies have identified associations between smoking, alcohol use, body mass index (BMI), and the levels of vitamin D with primary biliary cholangitis (PBC). However, there was a lack randomization control to estimate causal relationship. This study investigate estimates for effects those risk factors on PBC.The genetic instrument variants were extracted from genome-wide association in European ancestry. Two-sample mendelian (MR) multivariable used determine genetically estimates. Primary analyses consisted random-effects fix-mode inverse-variance-weighted methods, followed by secondary sensitivity verify results.Our showed that BMI factor PBC (OR 1.35; 95% CI=1.03-1.77; p=0.029). In addition, we found serum had protective effect after adjusting 0.51; CI=0.32-0.84; p=0.007). failed identify evidence supporting smoking intake associated countries.Our results enriched findings previous epidemiology provided MR concentrations independent PBC, suggesting ensuing sufficiency healthy lifestyles might be cost-effective measure early intervention PBC.
Language: Английский
Citations
37
Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 767 - 767
Published: Feb. 2, 2023
Vitamin D (vit D) is widely known for its role in calcium metabolism and importance the bone system. However, various studies have revealed a myriad of extra-skeletal functions, including cell differentiation proliferation, antibacterial, antioxidant, immunomodulatory, anti-inflammatory properties cells tissues. Vit mediates function via regulation gene expression by binding to receptor (VDR) which expressed almost all within body. This review summarizes pleiotropic effects vit D, emphasizing effect on different organ systems. It also provides comprehensive overview genetic epigenetic VDR genes pertaining immunity anti-inflammation. We speculate that context inflammation, might fulfill their roles as regulators through not only direct but mechanisms.
Language: Английский
Citations
21
Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 48, P. 217 - 231
Published: Sept. 1, 2024
Language: Английский
Citations
7
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Feb. 20, 2024
Metabolic-associated fatty liver disease (MAFLD) is a chronic characterized by the excessive accumulation of fat in hepatocytes. However, due to complex pathogenesis MAFLD, there are no officially approved drugs for treatment. Therefore, an urgent need find safe and effective anti-MAFLD drugs. Recently, relationship between gut microbiota MAFLD has been widely recognized, treating regulating may be new therapeutic strategy. Natural products, especially plant natural have attracted much attention treatment their multiple targets pathways few side effects. Moreover, structure function can influenced exposure products. effects products on through targeting underlying mechanisms poorly understood. Based above information address potential role we systematically summarize action prevention microbiota. This narrative review provides feasible ideas further exploration safer more MAFLD.
Language: Английский
Citations
6
World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(3), P. 361 - 377
Published: March 15, 2024
Diabetes, one of the world's top ten diseases, is known for its high mortality and complication rates low cure rate. Prediabetes precedes onset diabetes, during which effective treatment can reduce diabetes risk. risk factors include high-calorie high-fat diets, sedentary lifestyles, stress. Consequences may considerable damage to vital organs, including retina, liver, kidneys. Interventions treating prediabetes a healthy lifestyle diet pharmacological treatments. However, while these options are in short term, they fail due difficulty long-term implementation. Medications also be used treat prediabetes. This review examines prediabetic treatments, particularly metformin, glucagon-like peptide-1 receptor agonists, sodium glucose cotransporter 2 inhibitors, vitamin D, herbal medicines. Given remarkable impact on progression mellitus, it crucial intervene promptly effectively regulate current body research limited, there confusion surrounding clinically relevant medications. paper aims provide comprehensive summary pathogenesis pre-diabetes mellitus associated therapeutic drugs. The ultimate goal facilitate clinical utilization medications achieve efficient timely control mellitus.
Language: Английский
Citations
6
Expert Opinion on Therapeutic Targets, Journal Year: 2023, Volume and Issue: 27(11), P. 1145 - 1157
Published: Oct. 20, 2023
ABSTRACTIntroduction Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic worldwide, but underlying mechanisms are not fully understood. In recent years, a growing body evidence has emphasized therapeutic role vitamin D in NAFLD, specific mechanism remains to be investigated.Areas covered This review summarized roles D/VDR (vitamin receptor) pathway different types cells (such as hepatocytes, hepatic stellate cells, macrophages, T lymphocytes, and other immune cells) case NAFLD. Meanwhile, effects pathways gut-liver axis, adipose tissue-liver skeletal muscle-liver axis on development NAFLD were further reviewed. Relevant literature was searched PubMed for writing this review.Expert opinion The precise regulation regional signaling based cell-specific or tissue-specific function will help clarify potential which may provide new targets improve safety efficacy drugs.Display full sizeKEYWORDS: Adipose tissuegut-liver axishepatic cellsnon-alcoholic diseaseskeletal musclevitamin Article highlights there no pharmacological intervention NAFLD.Vitamin deficiency prevalent patients. However, relationship between still unclear.Vitamin receptor (VDR) mainly expressed non-parenchymal rather than hepatocytes normal liver.Vitamin can affect lipogenesis bile acid circulation inflammation by controlling macrophages polarization, maintain homeostasis regulating lymphocytes liver, inhibit fibrosis inhibiting activation.In addition, also alleviate improving intestinal permeability, microbial metabolites, inflammation, muscle dysfunction others through interplay extrahepatic tissues gut, tissues, muscles).Selective cell populations extra-hepatic future, contribute treatment.Reviewer disclosuresPeer reviewers manuscript have relevant financial relationships disclose.Declaration interestThe authors affiliations involvement with any organization entity interest conflict subject matter materials discussed manuscript. includes employment, consultancies, honoraria, stock ownership options, expert testimony, grants patents received pending, royalties.Additional informationFundingThe funded Foundation Fujian Key Laboratory Vascular Aging (grant number XHZDSYS202204) Provincial Natural Science projects 2019J01558 2020J01122587).
Language: Английский
Citations
11
Drug Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Abstract To investigate the effect of 1α,25(OH)2D3 on hepatic stellate cells and mechanism TGF-β1/Smad signaling pathway. LX2 were treated with TGF-β1 different concentrations 1α,25(OH)2D3. Cell proliferation was assessed using CCK8 assay to determine optimal concentration activity. The cell cycle apoptotic rates evaluated flow cytometry. expressions Samd2, Samd3, Samd4, Samd7 by western blotting, whereas expression MMP1, MMP13, TIMP-1 detected qPCR. Compared control group, group had a higher rate cells, blocked from G1 stage S stage, Samd7, MMP13 increased, while decreased. inhibits activation exerts anti-hepatic fibrosis effects downregulating upregulating MMP13.
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 378 - 378
Published: Jan. 21, 2025
Background: Total hip replacement (THR) significantly improves patients’ quality of life; however, prosthesis loosening remains a significant complication. Vitamin D, essential for calcium homeostasis and bone mineralization, is transported stabilized by vitamin D binding protein (VDBP). Common single nucleotide polymorphisms (SNPs) in the VDBP gene, rs4588 rs7041, may influence serum levels potentially impact THR outcomes. This study aimed to analyze association between these SNPs, 25(OH)D, their potential roles Methods: The included three patient groups: (1) patients undergoing arthroscopy after without (CA—Control Arthroplasty), (2) with (L—Loosening), (3) control group (C—Control). Genotyping rs7041 gene was conducted using PCR-RFLP TaqMan real-time PCR. Serum 25(OH)D were measured ELISA. Comparisons groups performed statistical analyses, including odds ratios (OR) significance testing (p-values). Results: There are differences concentrations L vs. CA (p < 0.0001), C = 0.0118), + 0.0013), 0.0008), 0.0001). Conclusions: findings suggest protective role against THR. SNP increase risk loosening, while highlight importance
Language: Английский
Citations
0
Endocrine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Language: Английский
Citations
0