Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(23), P. 7243 - 7243
Published: Nov. 23, 2023
The
EMCOVID
project
conducted
a
multi-centre
cohort
study
to
investigate
the
impact
of
COVID-19
on
patients
with
Multiple
Sclerosis
(pwMS)
receiving
disease-modifying
therapies
(DMTs).
aimed
evaluate
seroprevalence
and
persistence
SARS-CoV-2
antibodies
in
MS
enrolled
database.
DMTs
were
used
manage
by
reducing
relapses,
lesion
accumulation,
disability
progression.
However,
concerns
arose
regarding
susceptibility
pwMS
due
potential
interactions
between
immune
system,
as
well
immunomodulatory
effects
DMTs.
This
prospective
observational
utilized
data
from
(EMCOVID-19)
study.
Demographic
characteristics,
history,
laboratory
data,
serology,
symptoms
extracted
for
any
type
DMT.
relationship
demographics,
phenotype,
DMTs,
was
evaluated.
evolution
over
6-month
period
also
assessed.
included
709
pwMS,
376
providing
samples
at
follow-up
visit.
higher
among
than
general
population,
Interferon
treatment
being
significantly
associated
greater
(16.9%
vs.
8.4%;
p
0.003).
no
other
specific
DMT
showed
significant
association
antibody
presence.
A
total
32
(8.5%)
tested
positive
IgG,
IgM,
or
IgA
against
baseline,
but
then
negative
6
months.
Most
asymptomatic
and,
even
symptomatic
cases,
prognosis
generally
favourable.
undergoing
exhibited
population.
seroprevalence,
suggesting
more
robust
humoral
response.
provides
valuable
insights
into
contributes
our
understanding
amongst
this
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(16), P. 4692 - 4692
Published: Aug. 9, 2024
Background:
Depression
is
one
of
the
most
severe
sequelae
COVID-19,
with
major
depressive
disorder
often
characterized
by
disruption
in
white
matter
(WM)
connectivity
stemming
from
changes
brain
myelination.
This
study
aimed
to
quantitatively
assess
myelination
clinically
diagnosed
post-COVID
depression
(PCD)
using
recently
proposed
MRI
method,
macromolecular
proton
fraction
(MPF)
mapping.
Methods:
The
involved
63
recovered
COVID-19
patients
(52
mild,
11
moderate,
and
2
severe)
at
13.5
±
10.0
months
post-recovery,
matched
controls
without
prior
history
(n
=
19).
A
group
(PCD,
n
25)
was
identified
based
on
psychiatric
diagnosis,
while
a
comparison
(noPCD,
38)
included
participants
neurological
complications,
excluding
clinical
depression.
Results:
Fast
MPF
mapping
revealed
extensive
demyelination
PCD
patients,
particularly
juxtacortical
WM
(predominantly
occipital
lobe
medial
surface),
tracts
(inferior
fronto-occipital
fasciculus
(IFOF),
posterior
thalamic
radiation,
external
capsule,
sagittal
stratum,
tapetum),
grey
(GM)
structures
(hippocampus,
putamen,
globus
pallidus,
amygdala).
noPCD
also
displayed
notable
demyelination,
but
less
magnitude
propagation.
Multiple
regression
analysis
highlighted
IFOF
as
primary
predictor
Hamilton
scores,
presence,
severity.
number
symptoms
significant
acute
Conclusions:
study,
for
first
time,
reveals
numerous
GM
PCD,
outlining
key
biomarker.
Depression
is
one
of
the
most
severe
sequelae
COVID-19,
with
major
depressive
disorder
often
characterized
by
disruption
in
white
matter
(WM)
connectivity
,
stemming
from
changes
brain
myelination.
This
study
aimed
to
quantitatively
assess
myelination
clinically
diagnosed
post-COVID
depression
using
recently
proposed
MRI
method,
macromolecular
proton
fraction
(MPF)
mapping.
The
involved
63
recovered
COVID-19
patients
(52
mild,
11
moderate,
2
severe)
at
13.5±10.0
months
post-recovery,
matched
controls
without
prior
history
(n=19).
A
group
(PCD,
n=25)
was
identified
based
on
psychiatric
diagnosis,
while
a
comparison
(noPCD,
n=38)
included
participants
neurological
complications,
excluding
clinical
depression.
Fast
MPF
mapping
revealed
extensive
demyelination
PCD
patients,
particularly
juxtacortical
WM
(predominantly
occipital
lobe
and
medial
surface),
tracts
(inferior
fronto-occipital
fasciculus
(IFOF),
posterior
thalamic
radiation,
external
capsule,
sagittal
stratum,
tapetum),
grey
(GM)
structures
(hippocampus,
putamen,
globus
pallidus,
amygdala).
noPCD
also
displayed
notable
but
less
magnitude
propagation.
Multiple
regression
analysis
highlighted
IFOF
as
primary
predictor
presence
severity
according
Hamilton
scores.
number
symptoms
significant
acute
severity.
study,
for
first
time,
reveals
numerous
GM
PCD,
outlining
key
biomarker.
Long
Covid
is
a
heterogeneous
clinical
condition
in
which
Myalgic
Encephalomyelitis/Chronic
Fatigue
Syndrome
(ME/CFS)
and
brain
fog
stand
out
among
the
different
symptoms
syndromes.
The
cerebral
metabolic
alterations
neuroendocrine
disorders
seem
to
constitute
an
important
part
of
Covid.
Given
substantial
lack
drugs
effective
therapeutic
strategies,
hypothalamic
phospholipid
liposomes
have
been
on
market
for
several
years
as
adjuvant
therapy
resulting
from
disorders,
can
be
taken
into
consideration
overall
strategy
that
aims
control
associated
Their
pharmacological
mechanisms
effects
strongly
support
their
usefulness
Our
initial
experience
corroborates
this
rationale.
Further
research
imperative
order
obtain
robust
evidence.
Long
Covid
is
a
heterogeneous
clinical
condition
in
which
Myalgic
Encephalomyelitis/Chronic
Fatigue
Syndrome
(ME/CFS)
and
brain
fog
stand
out
among
the
different
symptoms
syndromes.
The
cerebral
metabolic
alterations
neuroendocrine
disorders
seem
to
constitute
an
important
part
of
Covid.
Given
substantial
lack
drugs
effective
therapeutic
strategies,
hypothalamic
phospholipid
liposomes
have
been
on
market
for
several
years
as
adjuvant
therapy
resulting
from
disorders,
can
be
taken
into
consideration
overall
strategy
that
aims
control
associated
Their
pharmacological
mechanisms
effects
strongly
support
their
usefulness
Our
initial
experience
corroborates
this
rationale.
Further
research
imperative
order
obtain
robust
evidence.
Reports — Medical Cases Images and Videos,
Journal Year:
2024,
Volume and Issue:
7(4), P. 104 - 104
Published: Nov. 21, 2024
Background:
Persistent
alterations
in
taste
and
smell
affect
a
significant
proportion
of
individuals
following
COVID-19,
representing
component
post-acute
COVID-19
syndrome,
commonly
referred
to
as
long
COVID.
The
degradation
sphingomyelin
by
acid
sphingomyelinase
is
regarded
biomarker
for
acquired
demyelinating
neuropathies.
Objectives:
This
study
was
aimed
enroll
women
who
contracted
during
pregnancy
experienced
persistent
and/or
more
than
1
year
post-infection,
comparison
pregnant
without
any
disturbances
these
senses.
Methods:
patients
were
subjected
questionnaire
investigating
disorders
after
the
infection.
Then,
levels
plasma
participants
assessed.
Results:
results
showed
that
had
been
infected
with
SARS
Cov-2
COVID
period
still
later,
double
infection
but
not
reported
analyzed
period.
Conclusions:
suggest
hypothesis
persistence
sensory
probably
due
failure
utilize
brain
circuitry
demyelination
resulting
from
chemosensory
dysfunction
olfactory
epithelium.
Revista Eletrônica Acervo Saúde,
Journal Year:
2024,
Volume and Issue:
24(11), P. e16907 - e16907
Published: Nov. 30, 2024
Objective:
Summarizes
the
current
knowledge
on
ageusia/dysgeusia
in
post-COVID
patients
focusing
taste
pathway
as
a
possible
gateway
for
central
nervous.
Literature
review:
Observational
studies
have
revealed
that
loss
of
smell
and
may
be
more
predictive
diagnosis
COVID-19
than
other
symptoms
such
fatigue,
fever
or
cough.
Taste
dysfunction
was
associated
with
moderate
infection.
The
duration
is
seven
days
average,
almost
all
recover
within
month.
However,
there
are
reports
whose
has
not
returned
to
normal
prolonged
periods
after
infection
still
alterations
certain
flavors.
Final
considerations:
mechanisms
by
which
these
occur
yet
well
clarified,
but
it
known
neuroinvasive
potential
SARS-CoV-2
play
role
pathophysiology
alterations,
due
hyperinflammatory
state,
viral
invasion
peripheral
nervous
system,
post-infection
immune
reactions.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(23), P. 7243 - 7243
Published: Nov. 23, 2023
The
EMCOVID
project
conducted
a
multi-centre
cohort
study
to
investigate
the
impact
of
COVID-19
on
patients
with
Multiple
Sclerosis
(pwMS)
receiving
disease-modifying
therapies
(DMTs).
aimed
evaluate
seroprevalence
and
persistence
SARS-CoV-2
antibodies
in
MS
enrolled
database.
DMTs
were
used
manage
by
reducing
relapses,
lesion
accumulation,
disability
progression.
However,
concerns
arose
regarding
susceptibility
pwMS
due
potential
interactions
between
immune
system,
as
well
immunomodulatory
effects
DMTs.
This
prospective
observational
utilized
data
from
(EMCOVID-19)
study.
Demographic
characteristics,
history,
laboratory
data,
serology,
symptoms
extracted
for
any
type
DMT.
relationship
demographics,
phenotype,
DMTs,
was
evaluated.
evolution
over
6-month
period
also
assessed.
included
709
pwMS,
376
providing
samples
at
follow-up
visit.
higher
among
than
general
population,
Interferon
treatment
being
significantly
associated
greater
(16.9%
vs.
8.4%;
p
0.003).
no
other
specific
DMT
showed
significant
association
antibody
presence.
A
total
32
(8.5%)
tested
positive
IgG,
IgM,
or
IgA
against
baseline,
but
then
negative
6
months.
Most
asymptomatic
and,
even
symptomatic
cases,
prognosis
generally
favourable.
undergoing
exhibited
population.
seroprevalence,
suggesting
more
robust
humoral
response.
provides
valuable
insights
into
contributes
our
understanding
amongst
this
