Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease DOI Creative Commons
Huimin Chen, Jiajia Cai,

Aozhe Wang

et al.

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 182, P. 112309 - 112309

Published: Oct. 1, 2023

Neuronal hyperactivity is a key abnormality in early stage Alzheimer's disease (AD). Medial entorhinal cortex (mEC) plays vital role memory function and affected AD. Growing evidence indicates benefits of regular exercise on cognitive humans with AD, although, the underlying mechanisms are not clear. Therefore, this study was designed to test effects 16 weeks treadmill spatial learning cellular 6-month-old 3xTg-AD mice. Whole-cell patch clamp used examine neuronal intrinsic excitability, spontaneous excitatory postsynaptic currents (sEPSCs) inhibitory (sIPSCs) mEC layer II/III pyramidal neurons following groups: wild type (WT + sham), (AD+sham), WT receiving Ex), AD (AD+Ex). We found that at behavioral level, decreased working errors radial arm maze (RAM) At we prevented abnormal increase neuron input resistance action potential firing mice compared sham AD+Ex mice; further, sEPSC amplitude frequency were normal but overactive AD+sham; additionally, GABAergic inhibition reduced AD+sham. In conclusion, our results indicate improves prevents network hyperexcitability by reducing excitability normalizing synaptic transmission

Language: Английский

Hippocampal SIRT1 signaling mediates the ameliorative effect of treadmill exercise on anxiety- and depression-like behavior in APP/PS1 mice DOI Creative Commons
Yarong Wang,

Zongbing Zhang,

Yumin Jiang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Dec. 18, 2024

Anxiety and depression-like symptoms occur in the early stages of Alzheimer's disease. Hippocampal Sirtuin 1 (SIRT1) signaling mediates anxiety- behavior. Exercise training improves anxiety behavior various disease models, such as rat chronic restraint stress model, model posttraumatic disorder, fetal alcohol spectrum disorders. Here, we aimed to investigate whether exercise ameliorates depression like behaviors APP/PS1 mice explore potential mechanisms.

Language: Английский

Citations

1

Treadmill running on neuropathic pain: via modulation of neuroinflammation DOI Creative Commons

Weichun He,

Shuang-Long Hou,

Kai-Bin Wang

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: June 26, 2024

Neuropathic pain is a type of chronic caused by an injury or somatosensory nervous system disease. Drugs and exercise could effectively relieve neuropathic pain, but no treatment can completely stop pain. The integration into management has attracted considerable interest in recent years, treadmill training the most used among therapies. be treated if its mechanism clarified. In association between neuroinflammation been explored. Neuroinflammation trigger proinflammatory cytokines, activate microglia, inhibit descending modulatory systems, promote overexpression brain-derived neurotrophic factor, which lead to generation hypersensitivity. Treadmill alleviate mainly regulating neuroinflammation, including inhibiting activity pro-inflammatory factors over activation microglia dorsal horn, expression mu opioid receptor rostral ventromedial medulla levels γ-aminobutyric acid factor. This article reviews summarizes research on effect role regulation explore benefits for treatment.

Language: Английский

Citations

0

Editorial: The impact of physical activity on white matter during healthy aging DOI Creative Commons
Elizabeta B. Mukaetova‐Ladinska, Yong Liu, Annalena Venneri

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Feb. 20, 2023

EDITORIAL article Front. Aging Neurosci., 20 February 2023Sec. Neurocognitive and Behavior Volume 15 - 2023 | https://doi.org/10.3389/fnagi.2023.1140767

Language: Английский

Citations

0

Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease DOI Creative Commons
Huimin Chen, Jiajia Cai,

Aozhe Wang

et al.

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 182, P. 112309 - 112309

Published: Oct. 1, 2023

Neuronal hyperactivity is a key abnormality in early stage Alzheimer's disease (AD). Medial entorhinal cortex (mEC) plays vital role memory function and affected AD. Growing evidence indicates benefits of regular exercise on cognitive humans with AD, although, the underlying mechanisms are not clear. Therefore, this study was designed to test effects 16 weeks treadmill spatial learning cellular 6-month-old 3xTg-AD mice. Whole-cell patch clamp used examine neuronal intrinsic excitability, spontaneous excitatory postsynaptic currents (sEPSCs) inhibitory (sIPSCs) mEC layer II/III pyramidal neurons following groups: wild type (WT + sham), (AD+sham), WT receiving Ex), AD (AD+Ex). We found that at behavioral level, decreased working errors radial arm maze (RAM) At we prevented abnormal increase neuron input resistance action potential firing mice compared sham AD+Ex mice; further, sEPSC amplitude frequency were normal but overactive AD+sham; additionally, GABAergic inhibition reduced AD+sham. In conclusion, our results indicate improves prevents network hyperexcitability by reducing excitability normalizing synaptic transmission

Language: Английский

Citations

0