Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures DOI Creative Commons
Rahel Feleke,

Simona Jogaudaite,

Elisavet Velentza‐Almpani

et al.

Acta Neuropathologica, Journal Year: 2025, Volume and Issue: 149(1)

Published: April 4, 2025

Language: Английский

Understanding monocyte-driven neuroinflammation in Alzheimers disease using human brain organoid microphysiological systems DOI Open Access

Chunhui Tian,

Zheng Ao,

Jonas Cerneckis

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Increasing evidence suggests that Alzheimer’s disease (AD) pathogenesis strongly correlates with neuroinflammation. Peripheral monocytes are crucial components of the human immune system may play a role in neuroinflammation, but their contribution to AD is largely understudied partially due lack appropriate models. Here, we present cortical organoid microphysiological systems (hCO-MPSs) for modeling dynamic neuroinflammation mediated by monocytes. By incorporating 3D printed devices into an existing protocol, 96 hCO-MPSs can be established significantly reduced necrosis and hypoxia as well enhanced viability within commonly used plate, each hCO-MPS consists doughnut-shaped hCO device per well. Using this approach, from patients exhibit higher infiltration, decreased amyloid-beta (Aβ) clearance, stronger inflammatory responses compared age-matched control donors. Moreover, pro-inflammatory effects such elevated astrocyte activation neuronal apoptosis were observed induced Furthermore, significant increase expression IL1B CCL3, both at transcriptional protein levels, indicated pivotal these cytokine chemokine monocyte-mediated Our findings provide insight understanding monocytes’ pathogenesis, user-friendly MPS models compatible laboratory settings, highlighting potential developing new therapeutics various neuroinflammatory diseases.

Language: Английский

Citations

0
Isorhapontigenin, a Potential Anti-Ad Natural Product by Multiple Pathways, Discovered Via Network Proximity and Gene Enrichment Analyses DOI
Pengfei Guo, Pengfei Guo, Jun Zhao

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Gliotransmission in physiologic and pathologic conditions DOI
Eunji Cheong, C. Justin Lee

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 93 - 116

Published: Jan. 1, 2025

Language: Английский

Citations

0
The future of healthy brain aging will be metabolic: a predictive lesson from data-driven modeling DOI Creative Commons
Luc Pellerin

Frontiers in Science, Journal Year: 2025, Volume and Issue: 3

Published: March 25, 2025

Language: Английский

Citations

0
Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures DOI Creative Commons
Rahel Feleke,

Simona Jogaudaite,

Elisavet Velentza‐Almpani

et al.

Acta Neuropathologica, Journal Year: 2025, Volume and Issue: 149(1)

Published: April 4, 2025

Language: Английский

Citations

0