GWAS Enhances Genomic Prediction Accuracy of Caviar Yield, Caviar Color and Body Weight Traits in Sturgeons Using Whole-Genome Sequencing Data DOI Open Access
Hailiang Song, Tian Dong, Wei Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9756 - 9756

Published: Sept. 9, 2024

Caviar yield, caviar color, and body weight are crucial economic traits in sturgeon breeding. Understanding the molecular mechanisms behind these is essential for their genetic improvement. In this study, we performed whole-genome sequencing on 673 Russian sturgeons, renowned high-quality caviar. With an average depth of 13.69×, obtained approximately 10.41 million single nucleotide polymorphisms (SNPs). Using a genome-wide association study (GWAS) with single-marker regression model, identified SNPs genes associated traits. Our findings revealed several candidate each trait: yield: TFAP2A, RPS6KA3, CRB3, TUBB, H2AFX, morc3, BAG1, RANBP2, PLA2G1B, NYAP1; color: NFX1, OTULIN, SRFBP1, PLEK, INHBA, NARS; weight: ACVR1, HTR4, fmnl2, INSIG2, GPD2, ACVR1C, TANC1, KCNH7, SLC16A13, XKR4, GALR2, RPL39, ACVR2A, ADCY10, ZEB2. Additionally, using genomic feature BLUP (GFBLUP) method, which combines linkage disequilibrium (LD) pruning markers GWAS prior information, improved prediction accuracy by 2%, 1.9%, 3.1% traits, respectively, compared to GBLUP method. conclusion, enhances our understanding underlying providing opportunities improvement through selection.

Language: Английский

Ubiquitous protein lactylation in health and diseases DOI Creative Commons
Junyong Wang, Ziyi Wang,

Q Wang

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Feb. 5, 2024

Abstract For decades, lactate has been considered a byproduct of glycolysis. The shuttle hypothesis shifted the paradigm, demonstrating that not only plays important roles in cellular metabolism but also communications, which can transcend compartment barriers and occur within among different cells, tissues organs. Recently, discovery induce novel post-translational modification, named lysine lactylation (Kla), brings forth new avenue to study nonmetabolic functions for lactate, inspired ‘gold rush’ academic commercial interest. Zhang et al. first showed Kla is manifested histones as epigenetic marks, then mounting evidences demonstrated occurs diverse non-histone proteins. widespread faithfully orchestrates numerous biological processes, such transcription, inflammatory responses. Notably, dysregulation touches myriad pathological processes. In this review, we comprehensively reviewed curated existing literature retrieve identified sites on both proteins summarized recent major advances toward its regulatory mechanism. We thoroughly investigated function underlying signaling pathway summarize how regulates various processes normal physiological states. addition, further highlight effects development human diseases including inflammation response, tumorigenesis, cardiovascular nervous system other complex diseases, might potentially contribute deeply understanding interpreting mechanism pathogenicity. Graphical

Language: Английский

Citations

37
Lactylation: the novel histone modification influence on gene expression, protein function, and disease DOI Creative Commons
Yue Hu,

Zhenglin He,

Zongjun Li

et al.

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 29, 2024

Abstract Lactic acid, traditionally considered as a metabolic waste product arising from glycolysis, has undergone resurgence in scientific interest since the discovery of Warburg effect tumor cells. Numerous studies have proved that lactic acid could promote angiogenesis and impair function immune cells within microenvironments. Nevertheless, precise molecular mechanisms governing these biological functions remain inadequately understood. Recently, been found to induce posttranslational modification, lactylation, may offer insight into acid's non-metabolic functions. Notably, modification proteins by lactylation emerged crucial mechanism which lactate regulates cellular processes. This article provides an overview acidification, outlines potential “writers” “erasers” responsible for protein presents patterns across different organisms, discusses diverse physiological roles lactylation. Besides, highlights latest research progress concerning regulatory pathological processes underscores its significance future investigations.

Language: Английский

Citations

32
Unlocking the multifaceted molecular functions and diverse disease implications of lactylation DOI
Fengyang Jing, Jianyun Zhang, Heyu Zhang

et al.

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

ABSTRACT In recent years, a significant breakthrough has emerged in biology, the identification of lactylation, novel post‐translational process. This intriguing modification is not limited to specific class proteins but occurs across diverse range, including histones, signalling molecules, enzymes, and substrates. It can exert broad regulatory role various diseases, ranging from developmental anomalies neurodegenerative disorders inflammation cancer. Thus, it presents exciting opportunities for exploring innovative treatment approaches. As result, there been surge research interest, leading deeper understanding molecular mechanisms functions underlying lactylation within physiological pathological processes. Here, we review detection biological disease effects, providing systematic overview this modification.

Language: Английский

Citations

12
Histone Lactylation Is Involved in Mouse Oocyte Maturation and Embryo Development DOI Open Access
Diqi Yang, Haoyi Zheng,

Wenjie Lu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4821 - 4821

Published: April 28, 2024

Numerous post-translational modifications are involved in oocyte maturation and embryo development. Recently, lactylation has emerged as a novel epigenetic modification implicated the regulation of diverse cellular processes. However, it remains unclear whether occurs during development Herein, lysine (Kla) were determined mouse early by immunofluorescence staining. Exogenous lactate was supplemented to explore consequences modulating histone levels on processes transcriptomics. Results demonstrated that lactylated proteins widely present mice with tissue- cell-specific distribution. During maturation, for H3K9la, H3K14la, H4K8la, H4K12la most intense at germinal vesicle (GV) stage subsequently weakened or disappeared. Further, supplementing culture medium 10 mM sodium elevated both rate Kla GV oocytes, there substantial increases metaphase II (MII) oocytes. It altered transcription molecules oxidative phosphorylation. Moreover, changed dynamically embryogenesis. Sodium enhanced significantly increased lactylation, while impacting glycolytic gene transcription. This study reveals roles development, providing new insights improving quality.

Language: Английский

Citations

5
Glis1 inhibits RTEC cellular senescence and renal fibrosis by downregulating histone lactylation in DKD DOI
Juan Chen, Junling He, Xiaoyue Wang

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123293 - 123293

Published: Dec. 1, 2024

Language: Английский

Citations

4
The lactate metabolism and protein lactylation in epilepsy DOI Creative Commons
Xi Kuang, Shuang Chen,

Qingmei Ye

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 14, 2025

Protein lactylation is a new form of post-translational modification that has recently been proposed. Lactoyl groups, derived mainly from the glycolytic product lactate, have linked to protein in brain tissue, which shown correlate with increased neuronal excitability. Ischemic stroke may promote glycolysis, leading lactate accumulation tissue. This heighten excitability by upregulating levels, potentially triggering post-stroke epilepsy. Although current clinical treatments for seizures advanced significantly, approximately 30% patients epilepsy remain unresponsive medication, and prevalence continues rise. study explores mechanisms epilepsy-associated death mediated metabolism lactylation. also examines potential histone deacetylase inhibitors alleviate modifying thereby offering fresh perspectives future research into pathogenesis treatment

Language: Английский

Citations

0
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency DOI
Qi Zhao,

Ming Zong,

Entong Song

et al.

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

Citations

0
The role of protein lactylation: A kaleidoscopic post-translational modification in cancer DOI Creative Commons
Marta Iozzo, Elisa Pardella, Elisa Giannoni

et al.

Molecular Cell, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The recently discovered lysine lactylation represents a critical post-translational modification with widespread implications in epigenetics and cancer biology. Initially identified on histones, has been also described non-histone proteins, playing pivotal role transcriptional activation, protein function, cellular processes. Two major sources of the lactyl moiety have currently distinguished: L-lactyl-CoA (precursor L-lactyl moiety) S-D-lactylglutathione D-lactyl moiety), which enable enzymatic non-enzymatic mechanisms lactylation, respectively. Although specific writers, erasers, readers this are still unclear, acetyltransferases deacetylases proposed as crucial mediators lactylation. Remarkably, exerts significant influence cancer-related pathways, thereby shaping behavior during malignant transformation metastatic cascade. Hence, recent insights into underscore its growing potential tumor biology, targeting is emerging opportunity for treatment.

Language: Английский

Citations

0
Lactylation: a promising therapeutic target in ischemia-reperfusion injury management DOI Creative Commons
Feixiang Wang, Guo Mu,

Zihang Yu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 13, 2025

Abstract Ischemia-reperfusion injury (IRI) is a critical condition that poses significant threat to patient safety. The production of lactate increases during the process IRI, and serves as crucial indicator for assessing severity such injury. Lactylation, newly discovered post-translational modification in 2019, induced by lactic acid predominantly occurs on lysine residues histone or nonhistone proteins. Extensive studies have demonstrated pivotal role lactylation pathogenesis progression various diseases, including melanoma, myocardial infarction, hepatocellular carcinoma, Alzheimer’s disease, nonalcoholic fatty liver disease. Additionally, marked correlation between inflammation has been observed. This article provides comprehensive review mechanism underlying IRI establish theoretical foundation better understanding interplay IRI.

Language: Английский

Citations

0
P300 regulates Melanophilin expression by modulating TFAP2A binding through histone acetylation DOI

Chan Song Jo,

Zhao Hairu,

Gyu Cheol Baek

et al.

Journal of Dermatological Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0