Estudio prospectivo de manifestaciones neuropsiquiátricas y cognitivas post accidente cerebrovascular

Vertex Revista Argentina de Psiquiatría, Journal Year: 2025, Volume and Issue: 35(166), P. 13 - 19

Published: Jan. 10, 2025

Introducción: El accidente cerebrovascular es un factor de riesgo para el trastorno neurocognitivo. Se ha reportado la presencia neurocognitivo post en 20 al 80 % los casos, según diferentes series. Asimismo, se reportan síntomas neuropsiquiátricos luego ese evento, siendo lo más frecuente depresión. objetivo este estudio fue determinar prevalencia neurocognitivo, depresión y otros sujetos con primer isquémico. Métodos: evaluaron adultos isquémico, a 3 12 meses del una evaluación neuropsicológica estándar, Inventario Depresión Beck-II e Neuropsiquiátrico Cummings. clasificaron casos como desempeño cognitivo normal, menor o mayor criterios DSM 5. Resultados: incluyeron 36 pacientes media edad 60.97 ± 16.98 años. registró (mayor menor) 63.8 66.6 año, conductuales 69.4 50 depresivos 16.6 22.2 año. La hipertensión arterial modificable correlacionó Discusión: detección necesaria base elevada reportada, permitiendo así correcto abordaje rehabilitación integral.

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Sleep dysfunction in stroke survivors impacts caregiver burden and functional recovery-an observational study

Sleep And Breathing, Journal Year: 2025, Volume and Issue: 29(1)

Published: Feb. 11, 2025

Language: Английский

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Modulating Gut Microbiota: The Mechanism of Electroacupuncture at the “Siguan” Acupoints in Alleviating Post-Stroke Depression

Neuropsychiatric Disease and Treatment, Journal Year: 2025, Volume and Issue: Volume 21, P. 281 - 294

Published: Feb. 1, 2025

Purpose: To explore the related mechanisms of electroacupuncture at "Siguan" acupoints in treating post-stroke depression (PSD). Methods: Fifty male SD rats were randomly divided into blank group, stroke PSD Siguan group and Bifidobacterium with 10 each group. The was given bilateral "Hegu" (LI4) "Taichong" (LR3), using disperse-dense wave a frequency 2Hz/10Hz for 30 minutes time. changes depressive behaviors observed according to sucrose consumption scores open field test gene data intestinal flora extracted analyze differences diversity, composition structure function among different groups. Results: behavior indexes higher than those Meanwhile, there disorders rats. Compared both had increased contents beneficial bacteria (Firmicutes Clostridia) decreased pathogenic (Bacteroidetes Bacteroidia). structures closer normal abundance "Metabolism Cofactors Vitamins" functional pathway lower that Conclusion: Electroacupuncture can improve depression-like by up-regulating probiotics, down-regulating bacteria, restoring physiological regulating flora. Keywords: depression, acupuncture, electroacupuncture, siguan acupoints, gut microbiota

Language: Английский

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The effect of mind- and body-based interventions on poststroke depression and its neural mechanisms: A systematic review and meta-analysis

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Post-stroke depression (PSD) is recognized as the most common psychiatric disorder following a stroke, impacting subsequent recovery and quality of life stroke survivors. In recent years, physical activities mindfulness have been proven to improve depression, however, it remained unknown whether those interventions were also effective in treatment PSD. This systematic review aims assess effects mind- body-based on PSD their underlying neural mechanisms. The (PROSPERO registration number: CRD42024514565) searched CINAHL, Cochrane, PsycINFO, PubMed, Scopus up March 11, 2024, focusing English-language studies. Inclusion criteria encompassed randomized controlled trials patients with using validated assessment tools, targeting body-based, mind-based, or mind-body interventions, while excluding psychological counseling passive movements. Two authors conducted data extraction checks for accuracy, risk bias was assessed PEDro scale, which evaluates study design methodology, yielding maximum score 10 points. Data by independent reviewers. A total 68 studies included, involving 6,825 participants, 54 these included meta-analysis. average 6.51 indicates good methodological quality, combined scoring highest at 7.44, highlighting variability among Meta-analysis results demonstrate that all significant impact (p < 0.05), effect sizes follows: (n = 66, Hedges’ g -0.572), mind-based 4, -0.549), 52, -0.532), 10, -0.805). meta-analysis revealed significantly improved post-stroke are more than alone. It suggested integrate additional elements into daily exercises survivors clinical practice can further alleviate depressive symptoms.

Language: Английский

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Relationship between weight-to-waist index and post-stroke depression

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(3)

Published: Feb. 26, 2025

The weight-to-waist index (WWI) serves as an innovative metric specifically designed to assess central obesity. However, the relationship between WWI and prevalence of post-stroke depression (PSD) remains inadequately explored in literature. To elucidate PSD. Data from National Health Nutrition Examination Survey 2005 2018 were analyzed. Multivariable logistic regression models propensity score matching utilized investigate association PSD, with adjustments for potential confounders. restricted cubic spline statistical method was applied explore non-linear associations. Participants elevated values had a significantly greater risk developing Specifically, individuals higher range exhibited more than twice likelihood PSD compared those lower (odds ratio = 2.21, 95% confidence interval: 1.84-2.66, P < 0.0001). After matching, remained 1.43, 95%confidence 1.09-1.88, 0.01). Tertile analysis revealed that participants highest tertile faced lowest tertile. Restricted further association, plateauing at values. There is significant increased Thus, regular screening should be implemented stroke patients enhance patient outcomes.

Language: Английский

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Ischemic stroke and post-stroke depression: the role of agomelatine

Published: Feb. 25, 2025

Ischemic stroke (IS) is a leading cause of death globally. IS occurs due to blockage cerebral arteries, neuronal injury, tissue death, and brain infarcts. This induces lack oxygenation the which neuroinflammation, characterised by interactions involving molecules can exacerbate damage but also aid recovery through processes like microglial phagocytosis. Post-stroke depression (PSD) affects 30–33% survivors, complicating with various symptoms. The pathophysiology PSD involves disruptions in glutamatergic monoaminergic systems, gut-brain axis, neuroinflammation. Agomelatine, an atypical antidepressant, potentially treat both PSD. It acts as melatonin receptor agonist serotonin antagonist, enhancing dopamine norepinephrine availability prefrontal cortex. Agomelatine’s neuroprotective, anti-inflammatory, antioxidative, antiapoptotic properties have been demonstrated research, where it reduces reactive oxygen species (ROS) levels activates Nrf2 pathway, promoting antioxidative enzyme expression. Additionally, prevents activation inhibiting toll-like 4 (TLR4)/nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) thus reducing inflammation. review examines PSD, highlighting agomelatine’s multifaceted therapeutic potential. distinct pharmacological profile minimal side effects make compelling candidate for treatment, necessitating further exploration optimise management improve patient outcomes.

Language: Английский

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Photochemically induced thrombosis combined with chronic restraint stress for modeling post-stroke depression in mice

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 28, 2025

Introduction Post-stroke depression (PSD) is a prevalent neuropsychiatric disorder associated with impaired recovery in stroke survivors, potentially linked to dysregulation of brain-derived neurotrophic factor (BDNF). This study aimed establish novel animal model PSD by integrating ischemic brain injury chronic psychological stress. Methods Mice were subjected photochemically induced thrombosis (PIT) generate focal lesions the parietal lobe, followed restraint stress (CRS) simulate post-stroke Behavioral assessments (sucrose preference test, forced swim tail suspension test) and molecular analyses (BDNF, synaptophysin [SYP], interleukin-1 [IL-1], tumor necrosis factor- α [TNF- ]) conducted evaluate depressive-like phenotypes neuroinflammatory markers. Results The PIT produced consistent damage, an average infarct area 2.580 ± 0.426% lobe. exposed PIT-CRS exhibited significant behaviors, including reduced sucrose ( p &lt; 0.001), increased immobility time test = 0.056), prolonged 0.168) compared Sham group. Molecular revealed marked downregulation BDNF 0.004) SYP 0.074), alongside upregulated IL-1 0.024) TNF-α 0.368) levels Conclusion provides comprehensive reproducible platform for studying PSD. By both stress, this captures multifaceted nature offers valuable insights into its pathophysiology. Future research using could pave way development targeted therapies

Language: Английский

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Research Progress of Post-Stroke Epilepsy: Pathophysiology, Diagnosis, Treatment and Prognosis

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 174 - 183

Published: Jan. 1, 2025

Language: Английский

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Development and Validation of a Risk Prediction Model for Depression in Patients with Stroke

Archives of Clinical Neuropsychology, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Stroke is the third leading cause of death and disability worldwide in 2019. In stroke patients, about one-third or more are affected by depression, which makes it a serious social public health problem. This study aims to create validate nomogram for early prediction identification depression patients. Cross-sectional data from 605 survivors aged 60 over CHARLS 2011, 2015 was used. Participants were split into training testing groups. Predictive factors identified using Least Absolute Shrinkage Selection Operator (LASSO) multivariable logistic regression, creation model. The model's performance assessed with Receiver Operating Characteristic (ROC) curves, Concordance Index (C-index), calibration plots, Decision Curve Analysis (DCA). It Activities Daily Living (ADL), Instrumental (IADL), sleep hours, uric acid, Triglyceride-Glucose-Body Mass (TyG-BMI) as risk post-stroke, integrated final nomogram's predictive deemed acceptable, ROC curve values 0.7512 (95% CI: 0.705-0.798) set 0.723 0.65-0.797) set. confirmed accuracy, DCA showed had clinical utility. Five key chosen predicting demonstrates evaluation serves tool forecasting this population.

Language: Английский

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Investigation of the relationship between food preferences and depression symptoms among undergraduate medical students: a cross-sectional study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 10, 2025

Introduction Depression is a psychological condition characterized by persistent low mood. This study investigates the relationship between depressive symptoms and food preferences in undergraduate students. Methods A cross-sectional design was employed among 502 students at Zanjan University of Medical Sciences. Data collection included validated questionnaires on preferences, depression levels (Beck Inventory), physical activity (IPAQ), along with anthropometric measurements. Food were analyzed for six groups: grains, fruits, vegetables, dairy, meat/fish, snacks. severity categorized into based BDI scores: normal (1–9), mild (10–16), borderline (17–20), moderate (21–30), severe (31–40), very (41–63). risk defined as odds belonging to higher Beck Inventory (BDI) category. Results Participants had lower vegetables but Adjusted analyses revealed that fruits (OR: 0.79; 95% CI: 0.68–0.98) 0.81; 0.71–0.94) significantly associated reduced risk, while snack increased 1.28; 1.03–1.68). However, association grain not statistically significant after adjustment 0.82; 0.74–1.03). Conclusion These findings highlight bidirectional link diet mental health, underscoring importance dietary interventions health strategies.

Language: Английский

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