medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 26, 2023
Abstract
Background
Selenium
is
a
trace
element
essential
for
the
normal
functions
of
different
human
body
systems
and
its
deficiency
has
been
associated
with
disease
states.
In
recent
years,
many
systematic
reviews
randomized
clinical
trials
in
humans
have
demonstrated
various
properties
selenium
such
as
antioxidant,
anti-inflammatory,
increased
immunity,
blocking
tumour
invasion
metastasis
pathological
conditions.
Therefore,
there
need
to
summarize
these
findings
one
single
paper
facilitate
decision
making
clinicians
policy
makers
regarding
inclusion
supplementation
routine
practice,
treatment
guidelines
medicine
list.
This
study
would
guide
researchers
towards
future
research
design
trials.
Objectives
The
objective
this
umbrella
review
assess
outcomes
states
determine
therapeutic
implications.
Eligibility
criteria
Only
reporting
after
use
alone
supplement
management
diseases
will
be
included.
While
primary
studies,
that
involved
administration
combination
other
elements
prevention
or
excluded.
Methods
following
databases
searched
by
three
independent
reviewers:
MEDLINE,
PUBMED,
EMBASE,
COCHRANE
database
reviews,
CINAHL,
JBI
Evidence
synthesis,
EPISTEMONIKOS,
SCOPUS,
Web
Science
TRIP
PRO.
Unpublished
using
ProQuest
dissertations
Theses,
Canadian
Agency
drugs
Technologies
Health
(CADTH)
Grey
matters
GOOGLE
scholar.
Systematic
published
last
10
years
(2013
2023).
There
no
language
restriction.
services
translator
employed
if
studies
languages
were
found.
Selection
data
extraction
done
3
reviewers.
Summary
presented
tables
accompanied
texts
where
necessary.
Strengths
limitations
first
on
supplements
management.
Secondly,
from
Nevertheless,
major
limitation
reduced
scope
eligible
because
only
reviews/
meta-analysis
included
considered.
Journal of Cellular Physiology,
Journal Year:
2024,
Volume and Issue:
239(4)
Published: Jan. 14, 2024
Abstract
Selenium
(Se),
as
one
of
the
essential
trace
elements,
plays
an
anti‐inflammatory,
antioxidation,
and
immune‐enhancing
effect
in
body.
In
addition,
Se
can
also
improve
nervous
system
damage
induced
by
various
factors.
Earlier
studies
have
described
important
role
mitochondrial
dynamic
imbalance
lipopolysaccharide
(LPS)‐induced
nerve
injury.
The
inositol
1,4,5‐triphosphate
receptor
(IP3R)/glucose‐regulated
protein
75
(GRP75)/voltage‐dependent
anion
channel
1
(VDAC1)
complex
is
considered
to
be
key
regulating
dynamics.
However,
it
not
clear
whether
Selenomethionine
(SeMet)
has
any
influence
on
IP3R/GRP75/VDAC1
complex.
Therefore,
aim
this
investigation
was
determine
SeMet
alleviate
LPS‐induced
brain
elucidate
function
it.
We
established
and/or
LPS
exposure
models
vivo
vitro
using
laying
hens
primary
chicken
cells.
noticed
that
reversed
endoplasmic
reticulum
stress
(ERS)
dynamics
significantly
prevented
occurrence
neuronal
apoptosis.
made
finding
morphological
observation
tissue
detection
related
genes
such
ERS,
complex,
calcium
signal
(Ca
2+
),
dynamics,
Other
than
that,
we
discovered
crucial
controlling
Ca
transport
between
mitochondrion
when
functions
a
neuroprotective
agent.
summary,
our
results
revealed
specific
mechanism
which
alleviated
apoptosis
for
first
time.
As
consequence,
great
potential
treatment
prevention
neurological
illnesses
(like
neurodegenerative
diseases).
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 13, 2024
Acute
ischemic
stroke
(AIS)
incidence
across
the
globe
is
on
rise,
and
deleterious
effects
have
not
yet
been
improved
with
use
of
current
pharmaceuticals.
Tissue
plasminogen
activator
(tPA)
has
many
risks
time
constraints,
making
it
difficult
to
even
as
standard
treatment.
Selenium
deficiency
a
strong
linear
correlation
among
various
populations.
Using
ADME-Tox
software,
selenious
acid
absorption
in
brain
cells,
tissue,
interstitium
was
modeled
under
conditions
determine
bioavailability
selenium
(Se)
using
IV
(intravenous)
infusion
doses.
Additionally,
we
studied
cytotoxicity
selenourea
human
dermal
fibroblasts
(HDF)
lung
carcinoma
cells
(A549)
overall
growth
toxicity
different
body
cell
lines
account
for
systemic
side
infusion.
Our
data
suggest
that
can
reach
dose-dependent
concentration
1.5µg/L
or
250µg/L
within
two
hours
one-time
infusion,
showing
ability
vasculature.
Furthermore,
viability
be
maintained
between
95%
100%
1nM
0.5nM
concentrations
acid.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 25, 2024
The
present
preliminary
study
aimed
to
provide
a
targeted
lipidomic
analysis
of
Hashimoto
(HT)
and
non-HT
patients
with
well-controlled
hypothyroidism
as
well
in
healthy
adults,
is
the
first
demonstrate
association
several
components
human
lipidome
relation
total
plasma
selenium
content.
All
age-,
sex-,
BMI-matched
controls
met
very
strict
qualification
criteria.
Se
levels
were
analyzed
by
ICP-MS,
studies
conducted
using
TQ-LC/MS.
40
acylcarnitines,
90
glycerophospholipids,
15
sphingomyelins
identified
quantified.
PCaaC26:0
PCaaC40:1
negatively
correlated
concentrations.
Other
lipids
that
concentrations
but
did
not
significant
differences
between
three
groups
Kruskal-Wallis
ANOVA
test
PCaaC32:0,
PCaeC30:0,
PCaeC36:5,
SMC18:0,
SM
C18:1.
In
multiple
linear
regression
analyses,
showed
negative
relationship,
whereas
different
phosphatidylcholines:
PCaaC24:0,
PCaaC26:0,
PCaeC30:1,
PCaeC34:0,
PCaeC36:4,
PCaeC42:0
positively
associated
presence
(H).
Different
hypothyroid
regardless
cause
condition.
Studies
on
larger
populations
are
needed
determine
cause-and-effect
relations
potential
mechanisms
underlying
these
associations.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 526 - 526
Published: Feb. 20, 2023
The
use
of
glucocorticoid
medications
is
known
to
cause
metabolic
side
effects
such
as
overeating,
excess
weight
gain,
and
insulin
resistance.
hypothalamus,
a
central
regulator
feeding
behavior
energy
expenditure,
highly
responsive
glucocorticoids,
it
has
been
proposed
that
plays
role
in
glucocorticoid-induced
defects.
Glucocorticoids
can
alter
the
expression
activity
antioxidant
enzymes
promote
accumulation
reactive
oxygen
species.
Recent
evidence
indicates
selenium
counter
critical
for
proper
hypothalamic
function.
This
study
sought
determine
whether
capable
protecting
cells
from
dysfunction
caused
by
exposure.
We
treated
mHypoE-44
mouse
with
corticosterone
on
cellular
physiology
involvement
selenium.
found
administration
rendered
more
vulnerable
endoplasmic
reticulum
stress
subsequent
impairment
signaling.
Supplementing
cell
culture
media
additional
alleviated
promoted
These
findings
implicate
protective
against
chronic
dysfunction.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 26, 2023
Abstract
Background
Selenium
is
a
trace
element
essential
for
the
normal
functions
of
different
human
body
systems
and
its
deficiency
has
been
associated
with
disease
states.
In
recent
years,
many
systematic
reviews
randomized
clinical
trials
in
humans
have
demonstrated
various
properties
selenium
such
as
antioxidant,
anti-inflammatory,
increased
immunity,
blocking
tumour
invasion
metastasis
pathological
conditions.
Therefore,
there
need
to
summarize
these
findings
one
single
paper
facilitate
decision
making
clinicians
policy
makers
regarding
inclusion
supplementation
routine
practice,
treatment
guidelines
medicine
list.
This
study
would
guide
researchers
towards
future
research
design
trials.
Objectives
The
objective
this
umbrella
review
assess
outcomes
states
determine
therapeutic
implications.
Eligibility
criteria
Only
reporting
after
use
alone
supplement
management
diseases
will
be
included.
While
primary
studies,
that
involved
administration
combination
other
elements
prevention
or
excluded.
Methods
following
databases
searched
by
three
independent
reviewers:
MEDLINE,
PUBMED,
EMBASE,
COCHRANE
database
reviews,
CINAHL,
JBI
Evidence
synthesis,
EPISTEMONIKOS,
SCOPUS,
Web
Science
TRIP
PRO.
Unpublished
using
ProQuest
dissertations
Theses,
Canadian
Agency
drugs
Technologies
Health
(CADTH)
Grey
matters
GOOGLE
scholar.
Systematic
published
last
10
years
(2013
2023).
There
no
language
restriction.
services
translator
employed
if
studies
languages
were
found.
Selection
data
extraction
done
3
reviewers.
Summary
presented
tables
accompanied
texts
where
necessary.
Strengths
limitations
first
on
supplements
management.
Secondly,
from
Nevertheless,
major
limitation
reduced
scope
eligible
because
only
reviews/
meta-analysis
included
considered.
