Biology Bulletin, Journal Year: 2024, Volume and Issue: 51(12), P. 3696 - 3700
Published: Dec. 1, 2024
Language: Английский
Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(5), P. 1115 - 1125
Published: July 29, 2023
Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for significant proportion cancer-related deaths worldwide. Although conventional therapies, such as surgical excision, chemotherapy, radiation, have been used to treat malignant melanoma, their efficacy often limited due the development resistance adverse side effects. Therefore, there growing interest in developing alternative treatment options melanoma are more effective less toxic. Terpenes, diverse group naturally occurring compounds plant origin, emerged potential anticancer agents ability inhibit tumor growth induce apoptosis cells. In this review, current understanding effects terpenes (including, thymoquinone, β-elemene, carvacrol, limonene, α-pinene, β-caryophyllene, perillyl alcohol, taxol, betulinic acid, α-bisabolol, ursolic linalool, lupeol, artesunate) was summarized, with special focus on therapeutic melanoma.
Language: Английский
Citations
45
Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1642 - 1642
Published: May 27, 2024
Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, minimal side effects. This paper begins by reviewing existing treatment methods drugs liver cancer. It then summarizes the therapeutic effects NPs sourced from various origins on Finally, we analyze potential mechanisms treating cancer, including inhibition angiogenesis, migration, invasion; regulation cell cycle; induction apoptosis, autophagy, pyroptosis, ferroptosis; influence tumor metabolism; immune regulation; intestinal function; key signaling pathways. systematic review aims provide comprehensive overview research treatment, offering foundation further application pharmaceuticals functional foods.
Language: Английский
Citations
10
Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(4), P. 3016 - 3034
Published: April 3, 2023
Nigella sativa L. (family Ranunculaceae), also known as black cumin, has been used in cuisine around the world for many years. Due to its health-promoting properties, it can be not only food industry but medicine. The main bioactive compound contained cumin extract is thymoquinone (TQ), which a special therapeutic role. results of research recent years confirmed hypoglycemic, hypolipemic, and hepatoprotective effects, among others. In addition, laboratory tests indicate immunomodulatory anticancer although there still lack data on mechanisms how they are involved fight against cancer. Including this plant material one’s diet both an element prophylaxis therapy supporting treatment process, including pharmacological treatment. However, attention should paid potential interactions with drugs chronic diseases.
Language: Английский
Citations
17
Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)
Published: Dec. 12, 2023
Abstract Colorectal neoplasms are one of the deadliest diseases among all cancers worldwide. Thymoquinone (TQ) is a natural compound Nigella sativa that has been used in traditional medicine against variety acute/chronic such as asthma, bronchitis, rheumatism, headache, back pain, anorexia, amenorrhea, paralysis, inflammation, mental disability, eczema, obesity, infections, depression, dysentery, hypertension, gastrointestinal, cardiovascular, hepatic, and renal disorders. This review aims to present detailed report on studies conducted anti-cancer properties TQ colorectal cancer, both vitro vivo. stands promising therapeutic agent can enhance efficacy existing cancer treatments while minimizing associated adverse effects. The combination with other anti-neoplastic agents promoted treatments. Further research needed acquire more comprehensive understanding its exact molecular targets pathways maximize clinical usefulness. These investigations may potentially aid development novel techniques combat drug resistance surmount obstacles presented by chemotherapy radiotherapy. Graphical
Language: Английский
Citations
16
Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: Oct. 31, 2023
Abstract Cancer is a malignant tumor that seriously threatens human life and health. At present, the main treatment methods include surgical resection, chemotherapy, radiotherapy, immunotherapy. However, mechanism of occurrence development complex, it produces resistance to some traditional methods, leading failure high mortality rate for patients. Therefore, exploring molecular mechanisms occurrence, development, drug very important task. MiRNAs are type non-coding small RNA regulate series biological effects by binding 3′-UTR target mRNA, degrading or inhibiting its translation. MiR-1-3p an member them, which abnormally expressed in various tumors closely related tumors. This article introduces miR-1-3p from multiple aspects, including production regulation, role clinical significance, resistance, approaches targeting miR-1-3p. Intended provide readers with comprehensive understanding Graphical
Language: Английский
Citations
10
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 230 - 230
Published: Jan. 18, 2025
Background: Asymptomatic liver steatosis constitutes an emerging issue worldwide. Therefore, we decided to explore relationships between selected types of microRNAs (miRNAs), serological markers fibrosis and hematological parameters in the course non-alcoholic fatty disease (NAFLD). Methods: Two hundred seven persons were included survey: 97 with NAFLD 110 healthy controls. Serological concentrations miR-126-3p, miR-197-3p, miR-1-3p measured all participants. Direct indices [procollagen I carboxyterminal propeptide (PICP), procollagen III aminoterminal (PIIINP), platelet-derived growth factor AB (PDGF-AB), transforming factor-α (TGF-α) laminin] together indirect (AAR, APRI, FIB-4 GPR) also evaluated. The assessment concerned: mean platelet volume (MPV), distribution width (PDW), plateletcrit (PCT), red blood cell (RDW), MPV (PLT) ratio (MPR), RDW PLT (RPR), neutrophil lymphocyte (LYM) (NLR), LYM (PLR) (RLR). Additionally, score BARD applied. Results: concentration miR-126-3p was higher, miR-197-3p lower group (p < 0.0001). correlated notably indices: negatively PDW 0.05) positively PLR 0.05). Conclusions: Significant correlations miRNA molecules indicate inflammation as a potential background create new possibilities for diagnostic approach.
Language: Английский
Citations
0
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: Feb. 28, 2025
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: March 5, 2025
Language: Английский
Citations
0
Food Frontiers, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Abstract Angiogenesis, vital for tumor growth and metastasis, is a promising target in cancer therapy. Natural compounds offer potential as antiangiogenic agents with reduced toxicity. This review provides comprehensive overview of natural product‐based therapies, focusing on molecular mechanisms therapeutic potential. A systematic search identified relevant articles from 2019 to 2023. Various compounds, including polyphenols, terpenes, alkaloids, cannabinoids, omega‐3 fatty acids, polysaccharides, proteins, carotenoids, were investigated their properties. Challenges such dose standardization, routes administration, side effects remain. Further studies, in‐depth animal models human epidemiological must elucidate clinical efficacy safety. Synergistic current bevacizumab tyrosine kinase inhibitors, should be explored. Additionally, the hormone‐dependent like genistein highlight need safety evaluation. In conclusion, products hold promise adjunctive therapies conventional antineoplastic drugs modulating angiogenesis cancer. However, robust trials are needed validate preclinical findings ensure efficacy.
Language: Английский
Citations
3
Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2108 - 2108
Published: Sept. 16, 2024
Background: It is essential to identify novel non-invasive markers of liver fibrosis for clinical and scientific purposes. Thus, the goal our survey was assess serological expression selected microRNAs (miRNAs) in patients with alcohol-related cirrhosis (ALC) correlate them other existing markers. Methods: Two hundred thirty-nine persons were enrolled study: one ALC healthy controls. Serological miR-126-3p, miR-197-3p miR-1-3p evaluated all participants. Direct (PICP, PIIINP, PDGF-AB, TGF-α laminin) together indirect indices (AAR, APRI, FIB-4 GPR) also assessed. The additional evaluation concerned hematological parameters: MPV, PDW, PCT, RDW, MPR, RPR NLR, PLR RLR. Results: lower compared controls (p < 0.0001). miR-126-3p correlated negatively AST 0.05) positively 0.001). direct fibrosis—positively PDGF-AB 0.005) 0.01). Significant negative relationships noticed between number neutrophils 0.05), laminin 0.05). Conclusions: achieved results observed correlations prove potential involvement examined miRNAs process fibrosis, giving a insight into diagnostics cirrhosis.
Language: Английский
Citations
2