An Overview of Recent Developments in the Management of Burn Injuries

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16357 - 16357

Published: Nov. 15, 2023

According to the World Health Organization (WHO), around 11 million people suffer from burns every year, and 180,000 die them. A burn is a condition in which heat, chemical substances, an electrical current or other factors cause tissue damage. Burns mainly affect skin, but can also deeper tissues such as bones muscles. When burned, skin loses its main functions, protection external environment, pathogens, evaporation heat loss. Depending on stage of burn, patient’s we need choose most appropriate treatment. Personalization multidisciplinary collaboration are key successful management patients. In this comprehensive review, have collected discussed available treatment options, focusing recent advances topical treatments, wound cleansing, dressings, grafting, nutrition, pain scar management.

Language: Английский

---

Skin Protection by Carotenoid Pigments

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1431 - 1431

Published: Jan. 24, 2024

Sunlight, despite its benefits, can pose a threat to the skin, which is natural protective barrier. Phototoxicity caused by overexposure, especially ultraviolet radiation (UVR), results in burns, accelerates photoaging, and causes skin cancer formation. Natural substances of plant origin, i.e., polyphenols, flavonoids, photosynthetic pigments, protect against effects radiation, acting not only as photoprotectors like filters but antioxidant anti-inflammatory remedies, alleviating photodamage skin. Plant-based formulations are gaining popularity an attractive alternative synthetic filters. Over past 20 years, large number studies have been published assess photoprotective products, primarily through their antioxidant, antimutagenic, anti-immunosuppressive activities. This review selects most important data on efficacy selected carotenoid representatives from vivo animal models humans, well vitro experiments performed fibroblast keratinocyte cell lines. Recent research carotenoids associated with lipid nanoparticles, nanoemulsions, liposomes, micelles reviewed. The focus was collecting those nanomaterials that serve improve bioavailability stability antioxidants activity.

Language: Английский

---

The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1181 - 1181

Published: March 6, 2025

Nano-drug delivery systems provide targeted solutions for addressing various drug challenges, leveraging nanotechnology to enhance solubility and permeability. Liposomes, explored several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or other surfactants, along with amphiphilic bile salts, they show superior stability pharmacokinetic behavior comparison conventional vesicular (liposomes niosomes). Bilosomes skin penetration, fluidize the stratum corneum, improve stability. In applications, bilosomes overcome drawbacks, offering improved bioavailability, controlled release, reduced side effects. Vaccines using demonstrate efficacy, intranasal, inhalation, ocular, buccal applications delivery, targeted, efficient, activities. Formulations vary based on active substances optimization techniques, showcasing versatility potential across diverse routes. Therefore, aim this comprehensive review was critically explore state-of-the-art therapeutic applications.

Language: Английский

---

Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2165 - 2165

Published: Aug. 21, 2023

Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such high bioavailability, low systemic toxicity, and improved patient compliance. However, effectiveness of TDDS is hindered by several factors, including barrier properties stratum corneum, nature carrier, conditions. In this paper, we provide an overview development from first-generation fourth-generation systems, highlighting characteristics each carrier in terms mechanism composition, penetration method, action, recent preclinical studies. We further investigated significant challenges encountered crucial significance clinical trials.

Language: Английский

---

Nanocosmetics and Skin Health: A Comprehensive Review of Nanomaterials in Cosmetic Formulations

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 22, 2024

The development of nanocosmetics nanotechnology has ushered in a new age cosmetic research, completely changing the skincare scene. This abstract investigates relationship between and nanotechnology, particularly emphasizing effects on skin health. Cosmetics, known as "nanocosmetics," use materials at nanoscale, typically 1 100 nanometers, to improve effectiveness delivery active chemicals. Nanotechnology cosmetics allows for sophisticated methods that provide enhanced stability tailored distribution, including nanoemulsions nanocapsules. breakthrough overcomes constraints conventional formulations by enabling entry ingredients into skin's deeper layers. Studies investigating health were included. encompassed vitro studies, animal models, clinical studies various designs. Exclusion criteria included focusing solely unrelated or review articles editorials, commentaries, conference abstracts. Nanocosmetics is groundbreaking provides creative answers range issues. As area develops, realizing full potential fostering ideal will need sustained research adherence safety regulations.

Language: Английский

---

Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species

Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103055 - 103055

Published: Jan. 23, 2024

Nanozymes with superior antioxidant properties offer new hope for treating oxidative stress-related inflammatory skin diseases. However, lacking sufficient catalytic activity or having complex material designs limit the application of current metallic nanozymes in Here, we report a simple and effective twin-defect platinum nanowires (Pt NWs) enzyme multiple mimetic enzymes broad-spectrum ROS scavenging capability treatment diseases mice (including psoriasis rosacea). Pt NWs simultaneous superoxide dismutase, glutathione peroxidase catalase exhibit cytoprotective effects against ROS-mediated damage at extremely low doses significantly improve outcomes psoriasis- rosacea-like mice. Meanwhile, these ultrasmall sizes allow nanomaterials to effectively penetrate do not produce significant biotoxicity. Therefore, have potential applications related stress inflammation.

Language: Английский

---

Dissolving microneedle synergistic rocaglamide-loaded liposome to regulate abnormal neutrophils for anti-psoriasis

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125180 - 125180

Published: Jan. 5, 2025

Language: Английский

---

Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 209 - 209

Published: Feb. 4, 2025

This study conducted a literature review by searching for articles related to the treatment of skin infections/wrinkles using nano-delivery systems containing natural compounds. The search was in various databases published last 10 years, with strict inclusion and exclusion criteria. Of 490 found, 40 were considered relevant. Acne vulgaris is common dermatological disorder characterised inflammation sebaceous glands, often resulting development pimples, cysts, scarring. Conventional treatments, including antibiotics topical retinoids, frequently demonstrate limitations such as side effects, resistance, insufficient absorption. Recent advancements nanotechnology have enabled creation innovative drug-delivery that enhance effectiveness reduce adverse effects anti-acne medications. Polyphenols flavonoids, bioactive compounds notable anti-inflammatory, antioxidant, antibacterial properties, are recognised their therapeutic acne treatment. However, practical application hindered solubility, stability, bioavailability. incorporation these into nanoparticle-based delivery has shown promise resolving challenges. Various nanoparticle platforms, lipid-based nanoparticles, polymeric solid lipid evaluated ability improve controlled release, targeted polyphenols flavonoids skin. advent polyphenol flavonoid-loaded nanoparticles marks new therapy era.

Language: Английский

---

Bigels as novel carriers of bioactive compounds: Applications and research trends

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 147, P. 109427 - 109427

Published: Oct. 20, 2023

Language: Английский

---

Antimicrobial Activity of Citrate-Coated Cerium Oxide Nanoparticles

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(4), P. 354 - 354

Published: Feb. 13, 2024

The purpose of this study was to investigate the antimicrobial activity citrate-stabilized sols cerium oxide nanoparticles at different concentrations via microbiological methods and compare effect with peroxidase nanoceria for subsequent development a regeneration-stimulating medical and/or veterinary wound-healing product providing new types action. object synthesized from aqueous solutions (III) nitrate hexahydrate citric acid (the size 3–5 nm, their aggregates were 60–130 nm). Nanoceria wide range (10−1–10−6 M) as well powder dry substance) used. Both bacterial fungal strains (Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Candida albicans, Aspergillus brasielensis) used studies. investigated across using three sequentially; studied by examining diffusion into agar, serial dilution method detect minimum inhibitory bactericidal concentrations, and, finally, gas chromatography mass-selective detection performed inhibition E. coli’s growth. To redox nanocerium, we intensity chemiluminescence in oxidation reaction luminol presence hydrogen peroxide. As result study’s use agar followed sowing, no significant evidence found. At same time, current against coli mass spectrometry, ability significantly inhibit growth reproduction microorganisms after 24 h particular, 48 incubation 10−2–10−5 M (48–95% reduction number microbes dose-dependent effect) determined optimum concentration. A reliable coated citrate established, increasing proportion concentration, confirming oxidative mechanism action nanoceria. Thus, have bacteriostatic effect, which is most pronounced 10−2–10−3 M. Unlike effects classical antiseptics, manifested 2 days increased during observation. nanomaterials, it advisable not qualitative semi-quantitative methods; rather, employment more accurate quantitative advised, chromatography–mass several incubation.

Language: Английский

---