The Potential Role of Butyrate in the Pathogenesis and Treatment of Autoimmune Rheumatic Diseases

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1760 - 1760

Published: Aug. 5, 2024

The gut microbiota is a complex ecosystem of microorganisms residing in the human gastrointestinal tract, playing crucial role various biological processes and overall health maintenance. Dysbiosis, an imbalance composition function microbiota, linked to systemic autoimmune diseases (SAD). Short-chain fatty acids (SCFAs), especially butyrate, produced by through fermentation dietary fibers, play significant immunomodulation maintaining intestinal homeostasis. Butyrate essential for colonocyte energy, anti-inflammatory responses, barrier integrity. Studies show reduced butyrate-producing bacteria SAD patients, suggesting that increasing butyrate levels could have therapeutic benefits. Butyrate's effects its potential been studied rheumatoid arthritis, Sjogren's syndrome, lupus erythematosus, sclerosis, Behçet's disease. Despite promising vitro animal model results, studies are limited, optimal strategies modulating dysbiosis SADs remain elusive. This review explores current evidence on immunoregulatory SAD.

Language: Английский

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Impact of the gut microbiome on skin fibrosis: a Mendelian randomization study

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: April 17, 2024

Skin fibrosis is a lesion in the dermis causing to itching, pain, and psychological stress. The gut microbiome plays as an essential role skin diseases developments. We conducted Mendelian randomization study determine causal association between fibrosis.

Language: Английский

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The Clinical Significance of Serum Biomarkers of the Intestinal Barrier in Systemic Sclerosis: A Cross-Sectional Study

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(4), P. 678 - 678

Published: April 18, 2023

Systemic sclerosis (SSc) is an immune-mediated connective tissue disease. Recent studies reported differences in the composition of intestinal microbiota (dysbiosis) patients with SSc compared to nonsclerodermic subjects. Dysbiosis may disrupt barrier, which leads immunological activation via microbial antigen and metabolite translocation. The study aimed assess permeability between controls examine correlation complications SSc. comprised 50 30 matched Serum markers: fatty acid binding protein, claudin-3, lipopolysaccharides (LPS) were determined using enzyme-linked immunosorbent assay. had a significantly increased concentration LPS control subjects (232.30 [149.00-347.70] versus 161.00 [83.92-252.20] pg/mL, p < 0.05). shorter duration (≤6 years) claudin-3 subgroup longer disease length: (280.75 [167.30-403.40] 186.00 [98.12-275.90] 0.05), (16.99 [12.41-39.59] 13.54 [10.29-15.47] ng/mL, esophageal dysmotility decreased level those without this complication (188.05 [102.31-264.40] 283.95 [203.20-356.30] Increased exacerbate course increase risk developing complications. Lower levels might be hallmark dysmotility.

Language: Английский

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Characteristics of skin microbiome associated with disease severity in systemic sclerosis

The Journal of Microbiology, Journal Year: 2025, Volume and Issue: 63(1), P. e:2409018 - e:2409018

Published: Jan. 24, 2025

Language: Английский

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Esophageal Dysmotility and Gut Microbiome Alterations in Systemic Sclerosis

Open Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 15(05), P. 267 - 285

Published: Jan. 1, 2025

Language: Английский

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Gut microbiota in very early systemic sclerosis: the first case-control taxonomic and functional characterisation highlighting an altered butyric acid profile

RMD Open, Journal Year: 2024, Volume and Issue: 10(4), P. e004647 - e004647

Published: Nov. 1, 2024

Objectives In systemic sclerosis (SSc), gastrointestinal involvement is one of the earliest events. We compared gut microbiota (GM), its short-chain fatty acids (SCFAs) and host-derived free (FFAs) in patients with very early diagnosis SSc (VEDOSS) definite SSc. Methods Stool samples 26 SSc, 18 VEDOSS 20 healthy controls (HC) were collected. The GM was assessed through 16S rRNA sequencing, while SCFAs FFAs by gas chromatography-mass spectrometry. Results VEDOSS, an increase Bacteroidales Oscillospirales orders a decrease Bacilli class, Blautia, Romboutsia, Streptococcus Turicibacter genera detected comparison HC. elevated number Acidaminococcaceae Sutterellaceae families, along Peptostreptococcaceae family Anaerostipes, Romboutsia found Patients had significantly lower butyrate higher acetate respect to Oscillospiraceae Anaerostipes genus, Alphaproteobacteria Lactobacillales order identified Moreover, exhibited valerate Conclusion A dysbiosis depletion beneficial anti-inflammatory bacteria (especially butyrate-producing) significant faecal VEDOSS. This imbalance may foster growth inflammatory microbes, worsening intestinal inflammation stages. potential administration disease phases might be considered as novel therapeutic approach mitigate discomfort progression preserving patient’s quality life.

Language: Английский

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Current Approaches to Prevent or Reverse Microbiome Dysbiosis in Chronic Inflammatory Rheumatic Diseases

Mediterranean Journal of Rheumatology, Journal Year: 2024, Volume and Issue: 35(2), P. 220 - 220

Published: June 1, 2024

Advances in knowledge of the microbiome and its relationship with immune system have led to a better understanding pathogenesis chronic inflammatory rheumatic diseases (CIRD). Indeed, dysbiosis now occupies particular place implications for determinism clinical expression CIRD, as well therapeutic response affected patients. Several approaches exist limit impact during CIRD. This review aimed present current strategies prevent or reverse based on existing knowledge, order provide practical information healthcare professionals treating patients suffering from

Language: Английский

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The effect of gut microbiome and plasma metabolome on systemic sclerosis: a bidirectional two-sample Mendelian randomization study

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 17, 2024

Background Cellular and molecular biology, combined with research on the human microbiome metabolome, have provided new insights into pathogenesis of systemic sclerosis (SSc). However, most studies gut microbiota (GM) metabolome in SSc are observational studies. The impact confounding factors reverse causation leads to different insights. To shed light this matter, we utilized Mendelian randomization (MR) determine causal effect GM/metabolites SSc. Methods Based summary-level data from genome-wide association studies, bidirectional Two-sample MR was conducted involving 196 GM, 1400 plasma metabolism, 9,095 Inverse Variance Weighting (IVW) mainly used for estimation. Results Forward analysis found that three GM two metabolites causally related IVW results showed Victivallaceae (family) (OR, 1.469; 95%CI, 1.099–1.963; p = 0.009) LachnospiraceaeUCG004 (genus) 1.548; 1.020–2.349; 0.04) were risk factor Conversely, Prevotella7 0.759; 0.578–0.997; 0.048)was a protective indicated Pregnenediol disulfate (C21H34O8S2) levels 1.164; 1.006–1.347; 0.041)was SSc, while Sphingomyelin (d18:1/19:0, d19:1/18:0) 0.821; 0.677–0.996; 0.045)was Reverse did not find relationship between above GM/plasma metabolites. Conclusion Our revealed These findings mechanism In particular, demonstrated despite its controversial role previous researches.

Language: Английский

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Current Update on the Role of Inflammation in the Pathogenesis of SSc

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 9, 2023

Systemic sclerosis (SSc), also known as scleroderma, is a systemic autoimmune rheumatic disease characterized by dysregulation of the immune system, fibrosis skin and visceral organs, vasculopathy. Inflammatory activation may be important in initiation progression vasculopathy response to homeostatic disturbance. Numerous factors trigger enable sustained inflammation such increased oxidative stress, involved progressivity severity. This chapter will focus on role involvement multiple mediators contributing activity SSc.

Language: Английский

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Impact of the gut microbiome on skin fibrosis: A Mendelian randomisation study

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 12, 2023

Abstract Objectives Skin fibrosis is a lesion in the dermis causing to itching, pain, and psychological stress. The gut microbiome plays as an essential role skin diseases developments. We conducted Mendelian randomization study determine causal association between fibrosis. Methods retrieved valid instrumental variables from genome-wide (GWAS) files of (n = 18340) by MiBioGen consortium. fibrosis-associated data were downloaded GWAS Catalog. Subsequently, two-sample randomisation (MR) analysis was performed whether related A reverse MR also on bacterial traits which causally associated with forward analysis. In addition, we MR-Pleiotropy Residual Sum Outlier remove outliers sensitivity verify our results. Results According inverse variance-weighted estimation, identified that ten ( Class Actinobacteria, Bacteroidia , family Bifidobacteriaceae Rikenellaceae, genus Lachnospiraceae (UCG004 group) Ruminococcaceae (UCG013 order Bacteroidales Bifidobacteriales Peptococcu s Victivallis ) negatively correlated while five Olsenella Oscillospira Turicibacter (NK4A136group) Sellimonas positively correlated. No results obtained significant heterogeneity or horizontal pleiotropy observed Conclusion There fibrosis, indicating existence gut–skin axis. This provides new breakthrough point for mechanistic clinical studies

Language: Английский

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