Expression landscape of RNA-binding proteins (RBPs) during adipogenesis and diet-induced obesity DOI Creative Commons
Ghida Dairi, Abdulrahman A. Alswaji,

Saleha Ahmed Alzahrani

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 31, 2023

Abstract RNA-binding proteins (RBPs) are key regulators of various cellular processes, including mRNA splicing, transport, stability, and translation. They play a crucial role in post-transcriptional gene regulation by interacting with specific RNA sequences or structures. RBPs can also influence the localization mRNAs within cell participate formation RNA-protein complexes that control expression. Dysregulation mutations have been associated wide range diseases, neurodegenerative disorders, cancer, developmental abnormalities. Recent studies highlighted importance regulating adipocyte differentiation, lipid metabolism, insulin sensitivity. However, global expression patterns functional contributions during adipogenesis functioning remain poorly understood. Identifying characterizing could provide valuable insights into molecular mechanisms underlying differentiation potentially lead to development novel therapeutic strategies for obesity-related disorders. Using combination bioinformatics tools experimental validation, we identified set may important roles functioning. We analyzed entire repertoire adipogenic murine line, 3T3-L1 assessed stromal vesicular fraction (SVF) mouse epididymal adipose tissue. evaluated impact high fat diet on adipocytes isolated from found number RBPS were significantly up- down-regulated cells enriched vascular In addition, they exhibited differential diet-induced obese mice compared mice. The majority these no known metabolism. These suggesting presence previously unknown regulatory mechanisms. Further investigation is needed understand functions their potential tissue This discovery opens up new avenues research uncovering intricate networks involved homeostasis.

Language: Английский

RNA binding proteins in senescence: A potential common linker for age-related diseases? DOI
Angelica Varesi, Lucrezia Irene Maria Campagnoli, Annalisa Barbieri

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101958 - 101958

Published: May 20, 2023

Language: Английский

Citations

12
RNA BINDING PROTEINS (RBPs) ON GENETIC STABILITY AND DISEASES DOI Creative Commons
Abdullahi Tunde Aborode, Ohilebo Abdulateef Abass,

Shaibu Nasiru

et al.

Global Medical Genetics, Journal Year: 2025, Volume and Issue: 12(1), P. 100032 - 100032

Published: Jan. 21, 2025

RNA-binding proteins (RBPs) are integral components of cellular machinery, playing crucial roles in the regulation gene expression and maintaining genetic stability. Their interactions with RNA molecules govern critical processes such as mRNA splicing, stability, localization, translation, which essential for proper function. These interact other to form ribonucleoprotein complexes (RNPs), hence controlling fate target RNAs. The interaction occurs via recognition motif, zinc finger domain, KH domain double stranded binding motif (all known domains (RBDs). found within coding sequences (intron exon domains), 5' untranslated regions (5'UTR) 3' (3'UTR). Dysregulation RBPs can lead genomic instability, contributing various pathologies, including cancer neurodegenerative diseases, metabolic disorders. This study comprehensively explores multifaceted highlighting their involvement integrity through modulation processing implications signalling pathways. Furthermore, it discusses how aberrant RBP function precipitate instability disease progression, emphasizing therapeutic potential targeting restoring homeostasis. Through an analysis current literature, this aims delineate role ensuring stability promise targets innovative strategies.

Language: Английский

Citations

0
Human antigen R -mediated autophagy-related gene 3 methylation enhances autophagy-driven ferroptosis in Crohn's disease colitis DOI
Zhipeng Li,

Yuan-Chen Chang,

Di He

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114565 - 114565

Published: April 3, 2025

Language: Английский

Citations

0
RNA-binding protein transcripts as potential biomarkers for detecting Primary Sclerosing Cholangitis and for predicting its progression to Cholangiocarcinoma DOI Creative Commons
Ugo Ala, Sharmila Fagoonee

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: June 6, 2024

Primary Sclerosing Cholangitis (PSC) is a persistent inflammatory liver condition that affects the bile ducts and commonly diagnosed in young individuals. Despite efforts to incorporate various clinical, biochemical molecular parameters for diagnosing PSC, it remains challenging, no biomarkers characteristic of disease have been identified hitherto. PSC linked with an uncertain prognosis, there pressing need explore multiomics databases establish new biomarker panel early detection PSC’s gradual progression into Cholangiocarcinoma (CCA) development effective therapeutic interventions. Apart from non-coding RNAs, other components Ribonucleoprotein (RNP) complex, such as RNA-Binding Proteins (RBPs), also hold great promise due their versatile expression pathological conditions. In present review, update on RBP transcripts show dysregulated CCA provided. Moreover, by utilizing bioinformatic data mining approach, we give insight those exhibit differential gall bladder, well body fluids, are promising predicting prognosis PSC. Expression were bioinformatically extracted public repositories usingTCGA Bile Duct Cancer dataset specific NCBI GEO datasets both CCA; more specifically, RBPs annotations obtained World database. Interestingly, our comprehensive analysis shows elevated non-canonical RBPs, FANCD2 , microtubule dynamics regulator, ASPM fluids patients compared respective controls, same trend being observed bladder cancer tissues. Consequently, manipulation tissue might be considered strategy mitigate onset patients, warrants further experimental investigation. The performed herein may helpful identification non-invasive its CCA. conclusion, future clinical research should investigate depth full potential human pathologies.

Language: Английский

Citations

2
Expression landscape of RNA-binding proteins (RBPs) during adipogenesis and diet-induced obesity DOI Creative Commons
Ghida Dairi, Abdulrahman A. Alswaji,

Saleha Ahmed Alzahrani

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 31, 2023

Abstract RNA-binding proteins (RBPs) are key regulators of various cellular processes, including mRNA splicing, transport, stability, and translation. They play a crucial role in post-transcriptional gene regulation by interacting with specific RNA sequences or structures. RBPs can also influence the localization mRNAs within cell participate formation RNA-protein complexes that control expression. Dysregulation mutations have been associated wide range diseases, neurodegenerative disorders, cancer, developmental abnormalities. Recent studies highlighted importance regulating adipocyte differentiation, lipid metabolism, insulin sensitivity. However, global expression patterns functional contributions during adipogenesis functioning remain poorly understood. Identifying characterizing could provide valuable insights into molecular mechanisms underlying differentiation potentially lead to development novel therapeutic strategies for obesity-related disorders. Using combination bioinformatics tools experimental validation, we identified set may important roles functioning. We analyzed entire repertoire adipogenic murine line, 3T3-L1 assessed stromal vesicular fraction (SVF) mouse epididymal adipose tissue. evaluated impact high fat diet on adipocytes isolated from found number RBPS were significantly up- down-regulated cells enriched vascular In addition, they exhibited differential diet-induced obese mice compared mice. The majority these no known metabolism. These suggesting presence previously unknown regulatory mechanisms. Further investigation is needed understand functions their potential tissue This discovery opens up new avenues research uncovering intricate networks involved homeostasis.

Language: Английский

Citations

0