Mind-Body Medicine in the Treatment of Depression: A Narrative Review of Efficacy, Safety and Mechanisms

Current Psychiatry Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 19, 2024

Abstract Purpose of the Review This narrative review examines efficacy, mechanisms and safety mind-body medicine (MBM) in treatment depression. We reviewed potential effects various MBM interventions such as yoga, tai chi, qigong, mindfulness-based nutrition on clinical subthreshold depressive symptoms. Recent Findings Current studies indicate a growing interest use for psychiatric disorders, including demonstrate efficacy reducing symptoms with fewer adverse costs compared to pharmacological treatments. Summary has significant improve mental health outcomes These encourage self-care stress management through behavioural, exercise, relaxation nutritional approaches. While existing data are promising, further, more rigorous required confirm long-term effectiveness determine role comprehensive depression strategies.

Language: Английский

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Boltzmann’s Theorem Revisited: Inaccurate Time-to-Action Clocks in Affective Disorders

Current Neuropharmacology, Journal Year: 2024, Volume and Issue: 22(11), P. 1762 - 1777

Published: March 19, 2024

Abstract: Timely goal-oriented behavior is essential for survival and shaped by experience. In this paper, a multileveled approach was employed, ranging from the polymorphic level through thermodynamic molecular, cellular, intracellular, extracellular, non-neuronal organelles electrophysiological waves, attesting signal variability. By adopting Boltzmann’s theorem as conceptualization of brain work, we found deviations excitation-inhibition balance wave decoupling, leading to wider variability in affective disorders compared healthy individuals. Recent evidence shows that overriding on-off design clock genes paces accuracy multilevel parallel sequencing clocks time-to-action more crucial behavioral reactions than their rapidity or delays. disorders, run free lack responsivity environmentally triggered are not able rescue mitochondria oxidative stress produce environmentally-triggered energy required accurate maintenance equilibrium. This maintenance, turn, dependent on gene transcription electron transporters, higher less disorders. From Boltzmannian energy-production perspective, option reversibility healthier time-toaction, reducing entropy implied. We employed logic gates show levelwise communication reversed conditions compensations implying role nonneural cells extracellular matrix return signaling.

Language: Английский

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The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer's Disease

Problems of Geroscience, Journal Year: 2023, Volume and Issue: 2, P. 80 - 87

Published: Dec. 18, 2023

Despite the fact that more than 90 % of tryptophan is metabolized via kynurenine pathway, serotonin pathway great importance for functioning central nervous system. The main products this are and melatonin. They provide maintenance sleep-wake mode, modulation oxidative stress activity, apoptosis neurons glial elements, regeneration neuroinflammation. In pathogenesis Alzheimer's disease, neuroinflammation plays one roles. Melatonin serotonin, being modulators its intensity, as well an important component neurochemical interactions cognitive functions, can be considered targets preventive therapeutic effects.

Language: Английский

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The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease

Advances in Gerontology, Journal Year: 2023, Volume and Issue: 13(3), P. 130 - 137

Published: Sept. 1, 2023

Language: Английский

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