Microbiology and Biotechnology Letters, Journal Year: 2023, Volume and Issue: 51(3), P. 250 - 256
Published: July 6, 2023
Language: Английский
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(5), P. 648 - 648
Published: April 26, 2023
Currently, there is an increased interest from both scientists and consumers in the application of cannabis/hemp/phytocannabinoids skin-related disorders. However, most previous investigations assessed pharmacological properties hemp extracts, cannabidiol (CBD), or tetrahydrocannabinol (THC), with very few studies focusing on minor phytocannabinoids hemp. In this context, current work explored vitro anti-melanoma, anti-melanogenic, anti-tyrosinase effects (CBD) three phytocannabinoids, namely cannabigerol (CBG), cannabinol (CBN), cannabichromene (CBC). Among tested human malignant melanoma cells (A375, SH4, G361), only A375 were highly susceptible to 48 h treatment four (IC50 values between 12.02 25.13 μg/mL). When melanogenesis was induced murine B16F10 by α-melanocyte stimulating hormone (αMSH), CBD, CBG, CBN significantly decreased extracellular (29.76–45.14% αMSH+ cells) intracellular (60.59–67.87% melanin content at 5 μg/mL. Lastly, (50–200 μg/mL) inhibited mushroom tyrosinase, whereas CBG CBC (100–200 down-regulated tyrosinase activity; contrast, CBD practically inactive. The data show that inhibition might not be responsible for reducing biosynthesis α-MSH-treated cells. By evaluating first time preliminary confirming similar study can expand utilization and, particular, novel cosmeceutical products skin care.
Language: Английский
Citations
19
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 74 - 74
Published: Dec. 20, 2023
Cannabis has been used as an herbal remedy for thousands of years, and recent research indicates promising new uses in medicine. So far, some studies have shown cannabinoids to be safe helping mitigate cancer-associated complications, including chemotherapy-induced nausea vomiting, pain, tumor growth. Researchers particularly interested the potential treating cancer due their ability regulate cancer-related cell cycle pathways, prompting many beneficial effects, such growth prevention, obstruction, death. Cannabinoids found affect tumors brain, prostate, colon rectum, breast, uterus, cervix, thyroid, skin, pancreas, lymph. However, full is yet understood. This review discusses current knowledge on applications three different side effects cancer—chemotherapy-induced development. The findings suggest that can address limit tumors, though a lack supporting clinical trials presents challenge use actual patients. An additional will examining whether any over one hundred naturally occurring or dozens synthetic compounds also exhibit useful properties. Currently, are underway; however, no regulatory agencies approved cannabinoid symptoms beyond antinausea.
Language: Английский
Citations
10
Salud Ciencia y Tecnología, Journal Year: 2024, Volume and Issue: 4, P. 937 - 937
Published: April 4, 2024
This review compiles information on the therapeutic applications of cannabinoids as a basis for their application in medicine treatment strategy. The main objective this was to analyze benefits such as: pain relief, antitumor effect, cell cycle regulation and immune stimulation. Information compiled from various scientific databases, PubMed, BioCell, Scielo, Elsevier, Redalyc, MDPI, PLOS, JAFC, BJPS Medicinal Chemistry Research, searching by keywords selecting according inclusion criteria. It possible identify potential those that endorse interaction receptors, thus remarkable relief However, effectiveness cannabis products varies stage disease dosage. concluded endocannabinoid system (ECS) offers important activities some diseases, whose molecular mechanisms action have been assessed different experimental models. clinical documented several pathologies cancer, epilepsy, glaucoma, arthritis, asthma, Alzheimer, Crohn, sclerosis, insomnia Parkinson, current legislation has opened way its industrial production use under control regulatory entities
Language: Английский
Citations
3
Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Background: Melanoma is a highly invasive and metastatic malignant tumor, with pathogenesis involving multiple signaling pathways transcription factors. Current treatments face significant challenges, including drug resistance, toxic side effects, recurrence. Purpose: This review aims to evaluate the therapeutic potential of natural products in treatment melanoma identify associated challenges future research opportunities. Methods: A comprehensive literature search was conducted using PubMed Web Science studies reporting on antimelanoma activity. Results: Natural demonstrate diverse pharmacological activities, antiproliferative, proapoptotic, antimetastatic highlighting their treatment. However, such as limited efficacy, safety concerns, lack standardized formulations remain barriers. Conclusion: provides insights into applications for melanoma, discusses existing limitations, proposes directions, contributing development effective safe treatments.
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: April 17, 2025
Melanoma is highly invasive and resistant to conventional treatments, accounting for nearly 75% of skin cancer-related deaths globally. Traditional therapies, such as chemotherapy immunotherapy, often exhibit limited efficacy are associated with significant side effects due systemic drug exposure. Microneedles (MNs), an emerging delivery system, offer multiple advantages, including safety, painlessness, minimal invasiveness, controlled release. Among these, hydrogel microneedles (HMNs) stand out their extracellular matrix-like structure swelling-induced continuous channels, which enable the direct therapeutic agents into tumor microenvironment (TME). This approach enhances bioavailability while reducing toxicity, establishing HMNs a promising platform melanoma treatment. review highlights recent advancements in therapy, focusing on applications biomarker extraction early diagnosis role supporting multimodal treatment strategies, chemotherapy, phototherapy, targeted combination therapy. Furthermore, current matrix materials fabrication techniques discussed. Finally, limitations critically analyzed, recommendations future research development provided.
Language: Английский
Citations
0
Journal of Biophotonics, Journal Year: 2024, Volume and Issue: 17(10)
Published: July 29, 2024
Malignant melanoma (MM) continues to claim millions of lives around the world due its limited therapeutic alternatives. Photodynamic therapy (PDT) has gained popularity in cancer treatment it increased potency and low off-target toxicity. Studies have pointed out that heterogeneity MM tumours reduces efficacy current approaches, including PDT, leading high chances recurrences post-treatment. Accumulating evidence suggests cannabidiol (CBD), a non-psychoactive derivative cannabis, can synergise with various anticancer agents increase their efficacy. However, CBD demonstrates bioavailability, which is attributed factors relating poor water compatibility, absorption rapid metabolism. Nanotechnology offers tools address these issues enhance biological efficiency targeted specificity agents. Herein, we highlighted standard modalities pitfalls, as well need for further investigation into PDT combination CBD.
Language: Английский
Citations
3
Metabolites, Journal Year: 2023, Volume and Issue: 13(7), P. 788 - 788
Published: June 24, 2023
Over the past decades, Colombia has suffered complex social problems related to illicit crops, including forced displacement, violence, and environmental damage, among other consequences for vulnerable populations. Considerable effort been made in regulation of predominantly Cannabis sativa, leading advances such as legalization medical cannabis its derivatives, improvement leaving an open window development scientific knowledge explore alternative uses. It is estimated that C. sativa can produce approximately 750 specialized secondary metabolites. Some most relevant due their anticancer properties, besides cannabinoids, are monoterpenes, sesquiterpenoids, triterpenoids, essential oils, flavonoids, phenolic compounds. However, despite increase research on subject, it necessary study primary metabolism plant identify key pathways great metabolic potential. For this purpose, a genome-scale reconstruction described contextualized using LC-QTOF-MS data obtained from leaf extract plants grown region Pesca-Boyaca, under greenhouse conditions at Clever Leaves facility. A compartmentalized model with 2101 reactions 1314 metabolites highlights associated fatty acid biosynthesis, steroids, amino acids, along purine, pyrimidine, glucose, starch, sucrose. Key were identified through metabolomic data, neurine, cannabisativine, cannflavin A, palmitoleic acid, geranylhydroquinone, steroids. They analyzed integrated into reconstruction, potential applications discussed. Cytotoxicity assays revealed high activity against gastric adenocarcinoma (AGS), melanoma cells (A375), lung carcinoma (A549), combined negligible impact healthy human skin cells.
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 27, 2024
The medicinal plant Cannabis sativa L. (C. sativa) is currently being extensively studied to determine the full extent of its therapeutic pharmacological potential. Δ9-tetrahydocannabinol (THC) and cannabidiol (CBD) are most thoroughly investigated compounds. We aimed explore anticancer activity cannabinoids mixture isolated from Lebanese C. in ratios comparable local plant, elucidate mechanism action breast cancer cells vitro. Cells were subjected cytotoxicity assay, cell cycle analysis, Annexin V/PI dual staining, death ELISA, immunofluorescence, addition western blot analysis apoptotic autophagy markers. further evaluated anti-metastatic effect on MDA-MB-231 using scratch wound-healing, trans-well migration invasion assays. Our results revealed promising benefits CBD/THC inhibiting growth by promoting cellular fragmentation, phosphatidylserine translocation outer membrane leaflet DNA fragmentation both lines while motility triple negative cells. In our study, was found exhibit a pro-apoptotic via activation mitochondrial pathway, independent ROS production also suggesting caspase-dependent pathway. Even though altered upon exposure cannabinoid mixture, data suggested that it not responsible inducing death. conclusion, study demonstrates CBD THC
Language: Английский
Citations
2
Journal of Food and Drug Analysis, Journal Year: 2023, Volume and Issue: 31(3), P. 408 - 435
Published: Aug. 31, 2023
Throughout history, medicinal and aromatic plants have been used extensively to cure a variety of ailments. This article provides comprehensive overview Cannabis sativa, specifically focusing on its legislative status, decriminalization, phytochemistry, antimicrobial activity, safety. The study begins by briefly outlining the plant's including cultivation, harvesting, storage methods. review analyzes properties sativa derivatives, examining their reported antiviral, antibacterial, antifungal, antiparasitic capabilities, which documented in databases such as Scopus, ScienceDirect, PubMed, Web Science. paper also discusses trends studies about plant object study, different bioactive compounds that were identified (phenolic acids, flavonoids, alkaloids, cannabinoids, terpenes), safe consumption several cannabis-based products candies, desserts, wine food flavoring. Furthermore, this has information legalization decriminalization cannabis use across globe with specific focus Morocco because it largest cultivated area C. plant. However, some substances potential not investigated due lack data activity. authors hope efforts will inspire future therapeutic uses ultimately leading improved health outcomes.
Language: Английский
Citations
5
Cells, Journal Year: 2023, Volume and Issue: 12(20), P. 2450 - 2450
Published: Oct. 13, 2023
Melanoma, an aggressive form of skin cancer, can be fatal if not diagnosed and treated early. Melanoma is widely recognized to resist advanced cancer treatments, including immune checkpoint inhibitors, kinase chemotherapy. Numerous studies have shown that various Cannabis sativa extracts exhibit potential anticancer effects against different types tumours both in vitro vivo. This study the first report PHEC-66, a extract, displays antiproliferative MM418-C1, MM329 MM96L melanoma cells. Although these findings suggest PHEC-66 has promising as pharmacotherapeutic agent for treatment, further research necessary evaluate its safety, efficacy, clinical applications.
Language: Английский
Citations
4