Evidence for the druggability of aldosterone targets in heart failure: A bioinformatics and data science-driven decision-making approach DOI
Lucas Salgado Rezende de Mendonça, Sergio Senar, Luana Lorena Moreira

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 171, P. 108124 - 108124

Published: Feb. 13, 2024

Language: Английский

POST-TRAUMATIC STRESS DISORDER, INSOMNIA, HEART RATE VARIABILITY AND METABOLIC SYNDROME (NARRATIVE REVIEW) DOI Creative Commons
A.A. Serhiyenko, Myroslav Baitsar,

V.B. Sehin

et al.

Proceedings of the Shevchenko Scientific Society Medical Sciences, Journal Year: 2024, Volume and Issue: 73(1)

Published: June 28, 2024

This narrative review was aimed to analyze the scientific data about association of post-traumatic stress disorder, insomnia, obstructive sleep apnea syndrome, dyssomnias, heart rate variability, metabolic type 2 diabetes mellitus, and cardiovascular autonomic neuropathy, along with potential pathophysiological mechanisms underlying these associations. The results experimental, cohort, prospective, randomized clinical studies provide evidence common pathogenetic pathways contributing their development. Searches were conducted in Scopus, Science Direct (from Elsevier), EBSCO, PubMed databases, including Medline databases. Additionally, a manual search publication bibliographies undertaken uncover research outcomes not accessible through online searches.

Language: Английский

Citations

6
Human Pinealectomy Syndrome and the Impact of Melatonin Replacement Therapy: 1‐Cardiovascular Function DOI
Claudia Cosentino, Fernanda Gaspar do Amaral, Luciana Aparecida Campos

et al.

Journal of Pineal Research, Journal Year: 2025, Volume and Issue: 77(3)

Published: April 1, 2025

The purpose of this investigational study was to assess the cardiovascular effects melatonin replacement therapy in pinealectomized patients. This a prospective open-label, single-arm proof-of-concept comprised 11 patients aged 16.7 ± 1.7 years, who had undergone pinealectomy, experienced no tumor recurrence, and exhibited undetectable salivary levels. A 6-month regimen (0.3 mg daily) administered. Ambulatory blood pressure monitoring conducted at baseline, 3-month, intervals. First all, hypertension observed Over course study, diastolic progressively decreased, reaching statistical significance 6 months. Pulse gradual increase, after Short-term variability increased significantly for both systolic pressures. Morning levels were decreased by therapy. Melatonin effect on average heart rate or its variability. Melatonin-deficient normotensive. these led reduced pressure, pulse enhanced short-term These results are consistent with improved health. Furthermore, melatonin's temporal specificity suggests that it might enhance nighttime recovery, heightening reactivity during wakefulness. While is used as dietary supplement similar effects, caution advised, further research needed optimize use various health disease contexts. Further, considering study's limitations, more extensive would strengthen findings.

Language: Английский

Citations

0
Melatonin and blood pressure: a narrative review DOI Creative Commons

O. Serhiyenko,

V.B. Sehin,

Vitaliy Kuznets

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2024, Volume and Issue: 20(3), P. 218 - 224

Published: June 27, 2024

Melatonin has several impacts on the cardiovascular system, including potential to reduce blood pressure in addition its role regulating sleep. It ability decrease adrenergic system activity and indirectly enhance endothelial function. can provide antihypertensive effects by stimu­lating own receptors central nervous peripheral arteries. In addition, melatonin is a treatment for patients with hypertension, “night-peaker” category. Howe­ver, results of only few randomized trials suggest that supplements are effective hypertension. lower due vasodilatation, direct blocking Ca2+ channels increased production nitric oxide endothelium; antioxidant properties; suppression sympathetic reduction norepinephrine production, as well activation parasympathetic system. Because drug usually taken at bedtime, it may increase duration quality sleep therefore during Low endogenous secretion be associated elevated nocturnal comorbid diseases. exhibits an excellent safety profile. Consequently, larger-scale, longer-term studies higher patient heterogeneity, biomarker identification, idiosyncrasies related use required. The aim this narrative review analyze peculiarities mecha­nisms action, effect exogenous parameters experiment clinic. search was conducted Scopus, Science Direct (from Elsevier), PubMed, MEDLINE databases. key words used were “melatonin,” “blood pressure”, “hypertension”, “obesity”, “metabolic syndrome”. We manually searched bibliography publications find study online did not yield.

Language: Английский

Citations

2
Special Issue on “Pleiotropic Benefits of Melatonin: From Basic Mechanisms to Disease” DOI Open Access
Yaiza Potes, Beatriz Caballero

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5223 - 5223

Published: March 9, 2023

Melatonin (N-acetyl-5-methoxytryptamine) is a multifunctional hormone that naturally produced from tryptophan and released rhythmically throughout the night by pineal gland to regulate sleep-wake cycles [...].

Language: Английский

Citations

4
Evidence for the druggability of aldosterone targets in heart failure: A bioinformatics and data science-driven decision-making approach DOI
Lucas Salgado Rezende de Mendonça, Sergio Senar, Luana Lorena Moreira

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 171, P. 108124 - 108124

Published: Feb. 13, 2024

Language: Английский

Citations

1