Published: Jan. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8465 - 8465
Published: Aug. 2, 2024
Lipid metabolism is a critical component in preserving homeostasis and health, lipids are significant chemicals involved energy living things. With the growing interest lipid recent years, an increasing number of studies have demonstrated close relationship between abnormalities development numerous human diseases, including cancer, cardiovascular, neurological, endocrine system diseases. Thus, understanding how aberrant contributes to related diseases it works offers theoretical foundation for treating preventing as well new avenues targeted treatment Therefore, we discuss processes various this review, cardiovascular system, neurodegenerative (such obesity type 2 diabetes mellitus), other cancer.
Language: Английский
Citations
10
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 90, P. 101998 - 101998
Published: July 5, 2023
Depression and Alzheimer´s disease (AD) are two disorders highly prevalent worldwide. affects more than 300 million people worldwide while AD 60% to 80% of the 55 cases dementia. Both diseases affected by aging with high prevalence in elderly share not only main brain areas but also several physiopathological mechanisms. is already ascribed as a risk factor development AD. Despite wide diversity pharmacological treatments currently available clinical practice for depression management, they remain associated slow recovery process treatment-resistant depression. On other hand, treatment essentially based symptomatology relieve. Thus, need new multi-target arises. Herein, we discuss current state-of-art regarding contribution endocannabinoid system (ECS) synaptic transmission processes, synapses plasticity neurogenesis consequently use exogenous cannabinoids on delaying progression Besides well-known imbalance neurotransmitter levels, including serotonin, noradrenaline, dopamine glutamate, recent scientific evidence highlights aberrant spine density, neuroinflammation, dysregulation neurotrophic levels formation amyloid beta (Aβ) peptides, mechanisms compromised The ECS these herein specified well pleiotropic effects phytocannabinoids. At end, it became evident that Cannabinol, Cannabidiol, Cannabigerol, Cannabidivarin Cannabichromene may act novel therapeutic targets, presenting potential pharmacotherapy both diseases.
Language: Английский
Citations
15
Frontiers in Neural Circuits, Journal Year: 2023, Volume and Issue: 17
Published: Sept. 29, 2023
GABAergic inhibitory neurons are the principal source of inhibition in brain. Traditionally, their role maintaining balance excitation-inhibition has been emphasized. Beyond homeostatic functions, recent circuit mapping and functional manipulation studies have revealed a wide range specific roles that circuits play dynamically tilting coupling across spatio-temporal scales. These span from gating compartment- input-specific signaling, gain modulation, shaping input–output functions synaptic plasticity, to generating signal-to-noise contrast, defining temporal windows for integration rate codes, as well organizing neural assemblies, coordinating inter-regional synchrony. thus instrumental controlling single-neuron computations behaviorally-linked network activity. The activity dependent modulation sensory mnemonic information processing by is pivotal formation maintenance episodic memories hippocampus. Here, we present an overview local long-range modulate dynamics disinhibition main output area hippocampus CA1, which crucial memory. Specifically, link findings pertaining neuron molecular markers, electrophysiological properties, wiring with function at level. Lastly, given CA1 particularly impaired during early stages Alzheimer’s disease, emphasize how these may contribute be involved pathophysiology.
Language: Английский
Citations
13
Marine Pollution Bulletin, Journal Year: 2024, Volume and Issue: 205, P. 116674 - 116674
Published: July 8, 2024
Language: Английский
Citations
3
Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1296 - 1296
Published: Oct. 13, 2024
Cannabis sativa is known for producing over 120 distinct phytocannabinoids, with Δ
Language: Английский
Citations
2
ChemMedChem, Journal Year: 2024, Volume and Issue: 19(22)
Published: July 31, 2024
A group of N-phenylbenzofuran-2-carboxamide and N-phenylbenzo[b]thiophene-2-carboxamide derivatives were designed synthesized as a novel class Aβ42 aggregation modulators. In the thioflavin-T based fluorescence kinetics study, compounds 4 a, b, 5 b possessing methoxyphenol pharmacophore able to demonstrate concentration dependent inhibition with maximum 54 % observed for compound b. contrast, incorporation 4-methoxyphenyl ring in d led significant increase fibrillogenesis demonstrating their ability accelerate aggregation. Compound exhibited 2.7-fold when tested at 25 μM. These results further confirmed by electron microscopy studies which demonstrates d, modulate fibrillogenesis. Compounds provided neuroprotection mouse hippocampal neuronal HT22 cells against Aβ42-induced cytotoxicity. Molecular docking suggest that orientation bicyclic aromatic rings (either benzofuran or benzo[b]thiophene) plays major role moderating either inhibit Our findings support application these pharmacological tools study mechanisms
Language: Английский
Citations
2
Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21
Published: Jan. 13, 2024
Background: Disturbed metabolism has been proposed as being involved in the pathogenesis of Alzheimer’s disease (AD), and more evidence from human AD brains is required. Objective: In this study, we attempted to identify or confirm modulations levels metabolites associated with postmortem brains. Methods: We performed metabolomics analyses using a gas chromatography mass spectrometry system patients confirmed AD, CERAD score B, control subjects. Results: Impaired phosphorylation glucose elevation several tricarboxylic acid (TCA) metabolites, except citrate, were observed degree impaired TCA cycle negatively positively correlated, respectively, clinical phenotypes AD. The uronic pathway modulated correlated amyloid-β content. associations nucleic synthesis amino depended on kinds metabolites; particular, contents ribose 5-phosphate, serine glycine while those ureidosuccinic indole-3-acetic Comprehensive statistical suggested that alterations inositol most closely Conclusions: present study revealed many novel between suggesting some these might serve potential therapeutic targets for
Language: Английский
Citations
1
Published: May 21, 2024
Alzheimer's disease (AD), a progressive neurodegenerative disorder, manifests through dysregulation of brain function and subsequent loss bodily control, attributed to β-amyloid plaque deposition TAU protein hyperphosphorylation aggregation, leading neuronal death. Concurrently, similar cannabinoids the ones derived from Cannabis sativa are present in endocannabinoid system, acting receptors CB1R CB2R other related such as Trpv-1 GPR-55, being extensively investigated for AD therapy. Given limited efficacy adverse effects current available treatments, alternative approaches crucial. Therefore, this review aims identify effective natural synthetic elucidate their beneficial actions treatment. PubMed Scopus databases were queried (2014–2024) using keywords "Alzheimer's disease" "cannabinoids". The majority (THC, CBD, AEA, etc.) (JWH-133, WIN55,212-2, CP55-940, included, showed promise improving memory, cognition, behavioral symptoms, potentially via pathways involving antioxidant selective agonists (such BDNF/TrkB/Akt pathway) immunomodulatory (TLR4/NF-κB p65 pathway). Combining anticholinesterase properties with cannabinoid moiety may enhance therapeutic responses, addressing cholinergic deficits brains. Thus, positive outcomes studies discussed supports further advancing clinical trials
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8630 - 8630
Published: Aug. 7, 2024
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, manifests through dysregulation of brain function and subsequent loss bodily control, attributed to β-amyloid plaque deposition TAU protein hyperphosphorylation aggregation, leading neuronal death. Concurrently, similar cannabinoids the ones derived from Cannabis sativa are present in endocannabinoid system, acting receptors CB1R CB2R other related such as Trpv-1 GPR-55, being extensively investigated for AD therapy. Given limited efficacy adverse effects current available treatments, alternative approaches crucial. Therefore, this review aims identify effective natural synthetic elucidate their beneficial actions treatment. PubMed Scopus databases were queried (2014–2024) using keywords “Alzheimer’s disease” “cannabinoids”. The majority (Δ9-THC, CBD, AEA, etc.) (JWH-133, WIN55,212-2, CP55-940, included showed promise improving memory, cognition, behavioral symptoms, potentially via pathways involving antioxidant selective agonists (such BDNF/TrkB/Akt pathway) immunomodulatory (TLR4/NF-κB p65 pathway). Combining anticholinesterase properties with cannabinoid moiety may enhance therapeutic responses, addressing cholinergic deficits brains. Thus, positive outcomes vast studies discussed support further advancing clinical trials
Language: Английский
Citations
1
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 475, P. 134925 - 134925
Published: June 15, 2024
Language: Английский
Citations
0