Endothelial cytoskeleton in mechanotransduction and vascular diseases

Journal of Biomechanics, Journal Year: 2025, Volume and Issue: 182, P. 112579 - 112579

Published: Feb. 9, 2025

Language: Английский

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Cadmium-induced Sertoli Cell Injury Through p38-MAPK and Related Signaling Proteins—A Study by RNA Sequencing

Endocrinology, Journal Year: 2023, Volume and Issue: 164(6)

Published: March 16, 2023

Abstract Environmental toxicants, such as cadmium, found in foods, water, and consumer products are known to induce male reproductive dysfunction. However, the underlying molecular mechanism(s) by which cadmium-induced Sertoli cell injury manifested a disruption of blood-testis barrier (BTB) remains unknown. Interestingly, one primary targets cadmium toxicity testis is cytoskeletons cells, which, turn, impedes junctions seminiferous epithelium. In order expand these earlier observations provide roadmap for future studies, we embarked study using RNA sequencing identify pertinent genes involved injury. Using bioinformatics analyses, multiple gene sets that regulated actin microtubule (MT) were identified along with components mitogen-activated protein kinase (MAPK) signaling several pathways. More important, have also discovered while expression p38-MAPK (also JNK or c-Jun) was considerably up- downregulated during injury, activated (phosphorylated) form upregulated. Importantly, doramapimod BIRB 796), specific p38-MARK inhibitor, shown selectively block p-p38 MAPK activation via phosphorylation indeed capable blocking including cell-permeability function, disruptive distribution BTB-associated proteins, organization MT cytoskeletons. These data helpful source information investigators probe role proteins and/or their cascades, besides MAPKs, likely utilized

Language: Английский

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A Conductive Polymer Restores Connexin43 Expression through the Suppression of Mitogen-Activated Protein Kinases to Improve Intercellular Communication and Alleviate Atrial Fibrillation

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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The Potential Role of Connexins in the Pathogenesis of Atherosclerosis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2600 - 2600

Published: Jan. 30, 2023

Connexins (Cx) are members of a protein family which enable extracellular and intercellular communication through hemichannels gap junctions (GJ), respectively. Cx take part in transporting important cell–cell messengers such as 3′,5′-cyclic adenosine monophosphate (cAMP), triphosphate (ATP), inositol 1,4,5-trisphosphate (IP3), among others. Therefore, they play significant role regulating cell homeostasis, proliferation, differentiation. Alterations distribution, degradation, post-translational modifications have been correlated with cancers, well cardiovascular neurological diseases. Depending on the isoform, shown either to promote or suppress development atherosclerosis, progressive inflammatory disease affecting large medium-sized arteries. might contribute progression by enhancing endothelial dysfunction, monocyte recruitment, vascular smooth muscle (VSMC) activation, inhibiting VSMC autophagy. Inhibition modulation expression specific isoforms could atherosclerotic plaque formation diminish pro-inflammatory conditions. A better understanding complexity atherosclerosis pathophysiology linked result developing novel therapeutic strategies. This review aims present pathogenesis discusses whether can become targets.

Language: Английский

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Circ_0049979 ameliorates myocardial infarction through improving Cx43-mediated endothelial functions

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 492, P. 117121 - 117121

Published: Oct. 9, 2024

Language: Английский

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