New discovery.,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 9
Published: Dec. 31, 2024
Diabetic
encephalopathy
(DE)
is
a
common
complication
in
diabetic
patients,
closely
linked
to
abnormal
immune
system
responses
that
drive
neuroinflammation,
neurodegeneration,
and
blood-brain
barrier
dysfunction.
Studies
indicate
cells,
inflammatory
mediators,
their
associated
pathological
mechanisms
play
critical
roles
causing
neuronal
damage
cognitive
decline
DE.
Here,
summarize
the
recent
progress,
56
relevant
articles
published
within
last
decade
were
selected
from
PubMed
search
using
keyword
“immune
response
encephalopathy.”
A
literature
review
was
used
understand
immune-related
cells
processes,
therapeutic
drugs
targeting
for
DE
treatment,
so
as
importance
of
regulation
pathogenesis
potential
strategies
drug
targets.
Moreover,
future
research
should
focus
on
elucidating
precise
regulatory
develop
targeted
treatments
aimed
at
improving
neurological
function
quality
life
patients
with
Diabetes/Metabolism Research and Reviews,
Journal Year:
2024,
Volume and Issue:
40(6)
Published: Sept. 1, 2024
Diabetic
encephalopathy
(DE)
is
a
severe
complication
that
occurs
in
the
central
nervous
system
(CNS)
and
leads
to
cognitive
impairment.
DE
involves
various
pathophysiological
processes,
its
pathogenesis
still
unclear.
This
review
summarised
current
research
on
of
diabetic
encephalopathy,
which
neuroinflammation,
oxidative
stress,
iron
homoeostasis,
blood-brain
barrier
disruption,
altered
gut
microbiota,
insulin
resistance,
etc.
Among
these
pathological
mechanisms,
neuroinflammation
has
been
focused
on.
paper
summarises
some
molecular
mechanisms
involved
including
Mammalian
Target
Rapamycin
(mTOR),
Lipocalin-2
(LCN-2),
Pyroptosis,
Advanced
Glycosylation
End
Products
(AGEs),
common
pro-inflammatory
factors.
In
addition,
we
discuss
recent
advances
study
potential
therapeutic
targets
for
treatment
against
neuroinflammation.
The
progressing
slowly,
more
needed
future.
Further
as
mechanism
conducive
discovery
effective
treatments
New discovery.,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 9
Published: Dec. 31, 2024
Diabetic
encephalopathy
(DE)
is
a
common
complication
in
diabetic
patients,
closely
linked
to
abnormal
immune
system
responses
that
drive
neuroinflammation,
neurodegeneration,
and
blood-brain
barrier
dysfunction.
Studies
indicate
cells,
inflammatory
mediators,
their
associated
pathological
mechanisms
play
critical
roles
causing
neuronal
damage
cognitive
decline
DE.
Here,
summarize
the
recent
progress,
56
relevant
articles
published
within
last
decade
were
selected
from
PubMed
search
using
keyword
“immune
response
encephalopathy.”
A
literature
review
was
used
understand
immune-related
cells
processes,
therapeutic
drugs
targeting
for
DE
treatment,
so
as
importance
of
regulation
pathogenesis
potential
strategies
drug
targets.
Moreover,
future
research
should
focus
on
elucidating
precise
regulatory
develop
targeted
treatments
aimed
at
improving
neurological
function
quality
life
patients
with
