Loss of Cdc42 in Exocrine Acini Decreases Saliva Secretion but Increases Tear Secretion—A Potential Model of Exocrine Gland Senescence DOI Open Access
Haruna Nagase, Akiko Shitara, Yuta Ohno

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17220 - 17220

Published: Dec. 7, 2023

Cdc42 is a small GTPase essential for the cell cycle, morphogenesis, and adhesion, it involved in polarity of epithelial cells. However, functional roles exocrine glands, such as maintenance acini water secretion, are not yet well understood. In this study, we generated acinar-cell-specific conditional knockout (Cdc42cKO) mice to assess their acinar cells physiological functions salivary glands (SGs) lacrimal (LGs). Our data revealed that loss altered luminal structures bulging induced apoptosis both parotid (PGs) LGs Cdc42cKO mice. Interestingly, saliva secretion response pilocarpine stimulation was decreased group, whereas tear increased. Consistent with results, protein expression channel AQP5 also PGs but conversely increased LGs. Moreover, changes occurred rather than duct The present study demonstrates structural survival SGs On other hand, depletion caused opposite phenomena between

Language: Английский

Molecular mechanisms of saliva secretion and hyposecretion DOI
Eun‐Ah Christine Song, Sul‐Hee Chung, Jeong Hee Kim

et al.

European Journal Of Oral Sciences, Journal Year: 2024, Volume and Issue: 132(2)

Published: Jan. 8, 2024

Abstract The exocrine salivary gland secretes saliva, a fundamental body component to maintain oral homeostasis. Saliva is composed of water, ions, and proteins such as amylase, mucins, immunoglobulins that play essential roles in the digestion food, lubrication, prevention dental caries periodontitis. An increasing number people experience saliva hyposecretion due aging, medications, Sjögren's syndrome, radiation therapy for head neck cancer. However, current treatments are mostly limited temporary symptomatic relief. This review explores molecular mechanisms underlying secretion provide insight into putative therapeutic targets treatment. Proteins implicated pathways, including Ca 2+ ‐signaling proteins, aquaporins, soluble N‐ethylmaleimide‐sensitive factor attachment protein receptors, tight junctions, aberrantly expressed localized patients with hyposecretion, syndrome. Analysis studies on suggests crosstalk between fluid secretory pathways via /protein kinase C cAMP/protein A regulates secretion. Impaired two may contribute hyposecretion. Future research detailed regulatory information define novel generate strategies

Language: Английский

Citations

2
Regulation of water flow in the ocular lens: new roles for aquaporins DOI Creative Commons
Paul J. Donaldson, Rosica S. Petrova, Nikhil U. Nair

et al.

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 602(13), P. 3041 - 3056

Published: Oct. 16, 2023

Abstract The ocular lens is an important determinant of overall vision quality whose refractive and transparent properties change throughout life. operates internal microcirculation system that generates circulating fluxes ions, water nutrients maintain the transparency lens. This flow a substantial hydrostatic pressure gradient which regulated by dual feedback uses mechanosensitive channels TRPV1 TRPV4 to sense decreases increases, respectively, in gradient. regulation (pressure) hence content, sets two key parameters, geometry index, determine Here we focus on roles played aquaporin family mediating fluxes, with specific AQP5 as channel We show addition regulating activity ion transporters, generate local osmotic gradients drive flow, TRPV1/4‐mediated also modulates membrane trafficking anterior influx pathway equatorial efflux zone Since both AQP5‐mediated permeability () can be altered changes tension applied surface via modulating ciliary muscle contraction propose extrinsic modulation potential mechanism alter ensure light remains focused retina image

Language: Английский

Citations

5
Effect of obesity on the aquaporin5 expression in the human placental and uterus tissues DOI Open Access
Kata Kira Kemény, Zoltán Kozinszky, Ábel Tamás Altorjay

et al.

Published: July 12, 2024

Abstract: Obesity and overweight also increasingly affect women of childbearing age pregnant women. In maternal obesity, the activation metabolic, inflammatory, oxidative stress pathways is proven, which appears to be a key step in placental uterus function pathological changes. Several recent studies have evidenced that aquaporins (AQPs) are critical players adipose tissue biology involved onset obesity. Our aimed investigate changes volume vascularization measure AQP5 expression total antioxidant capacity (TAC) placenta tissues obese normal-weight mothers. We aim plasma concentration. found dominance at 34 weeks normal pregnancy. The increased, decreased mothers compared control. increased group did not change placenta. TAC hypothesize prolongs length pregnancy inhibits contractions. Based on our findings, we can develop diagnostic tests provide new targets for tocolytic drug development.

Language: Английский

Citations

1
Primary Sjögren’s syndrome: new perspectives on salivary gland epithelial cells DOI Creative Commons
Jiaqi Hou, Yiyi Feng,

Zhixia Yang

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: July 17, 2024

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease primarily affecting exocrine glands such as the salivary glands, leading to impaired secretion and sicca symptoms. As mainstay of salivation, gland epithelial cells (SGECs) have an important role in pathology pSS. Emerging evidence suggests that interplay between immunological factors SGECs may not be initial trigger or sole mechanism responsible for xerostomia pSS, challenging conventional perceptions. To deepen our understanding, current research regarding pSS was reviewed. Among extensive aberrations cellular architecture function, this review highlighted certain alterations were identified occur independently absence lymphocytic infiltration. In particular, some these serve upstream immuno-inflammatory responses. These findings underscore significance introspecting pathogenesis developing interventions targeting early stages disease.

Language: Английский

Citations

1
Aquaporin 5 in the eye: Expression, function, and roles in ocular diseases DOI
Kaier Zhang, Guohu Di, Ying Bai

et al.

Experimental Eye Research, Journal Year: 2023, Volume and Issue: 233, P. 109557 - 109557

Published: June 26, 2023

Language: Английский

Citations

3
Effect of Obesity on Aquaporin5 Expression in Human Placental and Uterus Tissues DOI Open Access
Kata Kira Kemény, Zoltán Kozinszky, Ábel Tamás Altorjay

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(15), P. 4490 - 4490

Published: July 31, 2024

Obesity and overweight are also becoming more prevalent among women of childbearing age pregnant women. In maternal obesity, the activation metabolic, inflammatory, oxidative stress pathways is proven, which appears to be a key step in pathological changes observed placental uterine function. Several recent studies have evidenced that aquaporins (AQPs) critical players adipose tissue biology involved onset obesity.

Language: Английский

Citations

0
Shatianyu (Citrus grandis L. Osbeck) whole fruit alleviated loperamide-induced constipation via enhancing gut microbiota-mediated intestinal serotonin secretion and mucosal barrier homeostasis DOI
Mei Deng, Jiamin Ye,

Ruifen Zhang

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(21), P. 10614 - 10627

Published: Jan. 1, 2024

The effects of Citrus grandis Shatianyu whole fruit powder enriched in flavonoids and dietary fiber on loperamide-induced constipation after a 4-week administration the diet, together with possible microbiota-mediated mechanisms were explored.

Language: Английский

Citations

0
Morphology, glicohistochemistry and immunolocalization of Aquaporin 5 in the mandibular gland of the giant anteater (Myrmecophaga tridactyla) DOI
Bruno César Schimming, Rafael Oliveira Bordin, Taís Harumi de Castro Sasahara

et al.

Annals of Anatomy - Anatomischer Anzeiger, Journal Year: 2024, Volume and Issue: unknown, P. 152367 - 152367

Published: Dec. 1, 2024

Language: Английский

Citations

0
Exploring Aquaporins in Human Studies: Mechanisms and Therapeutic Potential in Critical Illness DOI Creative Commons
Charikleia S. Vrettou, Vasileios Issaris, Stelios Kokkoris

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1688 - 1688

Published: Dec. 20, 2024

Aquaporins (AQPs) are membrane proteins facilitating water and other small solutes to be transported across cell membranes. They crucial in maintaining cellular homeostasis by regulating permeability various tissues. Moreover, they regulate migration, signaling pathways, inflammation, tumor growth, metastasis. In critically ill patients, such as trauma, sepsis, patients with acute respiratory distress syndrome (ARDS), which frequently encountered intensive care units (ICUs), transport regulation is for homeostasis, dysregulation can lead edema or dehydration, the latter also implicating hemodynamic compromise. Indeed, AQPs involved fluid organs, including lungs, kidneys, brain, where their dysfunction exacerbate conditions like ARDS, kidney injury (AKI), cerebral edema. this review, we discuss implication of clinical entities ICUs, systemic inflammation AKI, brain due different types primary from a perspective. Current possible future therapeutic implications considered.

Language: Английский

Citations

0
Involvement of aquaporin 5 and Na-K-2Cl cotransporter 1 in the pathogenesis of primary focal hyperhidrosis: evidence from the primary sweat gland cell culture DOI
Jianbo Lin,

Lin Min,

Quan Du

et al.

AJP Cell Physiology, Journal Year: 2023, Volume and Issue: 326(1), P. C206 - C213

Published: Dec. 4, 2023

People with primary focal hyperhidrosis (PFH) usually have an overactive sympathetic nervous system, which can activate the sweat glands through chemical messenger of acetylcholine. The role aquaporin 5 (AQP5) and Na-K-2Cl cotransporter 1 (NKCC1) in PFH is still unknown. relative mRNA protein levels AQP5 NKCC1 gland tissues three subtypes patients (primary palmar hyperhidrosis, PPH; axillary PAH; craniofacial PCH) were detected real-time PCR (qPCR) Western blot. Primary cells from healthy controls (NPFH-SG) incubated different concentrations acetylcholine, expression also detected. NPFH-SG transfected si-AQP5 or shNKCC1, acetylcholine stimulation-induced calcium transients assayed Fluo-3 AM assay. Upregulated observed tissues, demonstrated a positive Pearson correlation PPH (

Language: Английский

Citations

0