Loss of Cdc42 in Exocrine Acini Decreases Saliva Secretion but Increases Tear Secretion—A Potential Model of Exocrine Gland Senescence DOI Open Access
Haruna Nagase, Akiko Shitara, Yuta Ohno

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17220 - 17220

Published: Dec. 7, 2023

Cdc42 is a small GTPase essential for the cell cycle, morphogenesis, and adhesion, it involved in polarity of epithelial cells. However, functional roles exocrine glands, such as maintenance acini water secretion, are not yet well understood. In this study, we generated acinar-cell-specific conditional knockout (Cdc42cKO) mice to assess their acinar cells physiological functions salivary glands (SGs) lacrimal (LGs). Our data revealed that loss altered luminal structures bulging induced apoptosis both parotid (PGs) LGs Cdc42cKO mice. Interestingly, saliva secretion response pilocarpine stimulation was decreased group, whereas tear increased. Consistent with results, protein expression channel AQP5 also PGs but conversely increased LGs. Moreover, changes occurred rather than duct The present study demonstrates structural survival SGs On other hand, depletion caused opposite phenomena between

Language: Английский

Loss of Cdc42 in Exocrine Acini Decreases Saliva Secretion but Increases Tear Secretion—A Potential Model of Exocrine Gland Senescence DOI Open Access
Haruna Nagase, Akiko Shitara, Yuta Ohno

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17220 - 17220

Published: Dec. 7, 2023

Cdc42 is a small GTPase essential for the cell cycle, morphogenesis, and adhesion, it involved in polarity of epithelial cells. However, functional roles exocrine glands, such as maintenance acini water secretion, are not yet well understood. In this study, we generated acinar-cell-specific conditional knockout (Cdc42cKO) mice to assess their acinar cells physiological functions salivary glands (SGs) lacrimal (LGs). Our data revealed that loss altered luminal structures bulging induced apoptosis both parotid (PGs) LGs Cdc42cKO mice. Interestingly, saliva secretion response pilocarpine stimulation was decreased group, whereas tear increased. Consistent with results, protein expression channel AQP5 also PGs but conversely increased LGs. Moreover, changes occurred rather than duct The present study demonstrates structural survival SGs On other hand, depletion caused opposite phenomena between

Language: Английский

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