Advances in microbial physiology/Advances in Microbial Physiology, Journal Year: 2024, Volume and Issue: unknown, P. 259 - 323
Published: Jan. 1, 2024
Language: Английский
Veterinary Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 110469 - 110469
Published: March 1, 2025
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 948 - 948
Published: April 20, 2025
Trillions of microorganisms play a pivotal role in maintaining health and preventing disease humans. Their presence influences daily life, habits, energy levels, pathologies. The present narrative review synthesized recent studies microbial diversity across organ systems. composition the microbiota regulates intestinal barrier, modulates immune response, metabolism, produces essential compounds such as short-chain fatty acids neurotransmitters. Dysbiosis is associated with numerous pathologies, including metabolic, autoimmune, neurodegenerative, cardiovascular diseases. key to physiological balance reducing risk. Therapeutic interventions, probiotics, prebiotics, postbiotics, microbiome transplantation, offer promising perspectives restoring homeostasis chronic
Language: Английский
Citations
0
Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)
Published: May 19, 2025
The lung-brain axis represents a complex bidirectional communication network that is pivotal in the crosstalk between respiratory and neurological functions. This review summarizes current understanding of mechanisms protein markers mediate effects lung diseases on brain health. In this review, we explore linking injury to neurocognitive impairments, focusing neural pathways, immune regulation inflammatory responses, microorganism hypoxemia. Specifically, highlight role vagus nerve modulating central nervous system response pulmonary stimuli; Additionally, regulatory function underscored, with evidence suggesting lung-derived mediators can traverse blood-brain barrier, induce neuroinflammation cognitive decline; Furthermore, discuss potential microbiota influence through microbial translocation activation; Finally, impact hypoxemia examined, findings indicating it exacerbate cerebral via oxidative stress impaired perfusion. Moreover, analyze how conditions, such as pneumonia, ALI/ARDS, asthma, contribute dysfunction. Prolonged mechanical ventilation also impairment. Conversely, (e.g., stroke, traumatic injury) lead acute complications. addition, TLR4, ACE2, A-SAA, HMGB1, TREM2 are crucial correlate disease severity. We emerging therapeutic strategies targeting axis, including immunomodulation microbiome engineering. Overall, interplay for developing integrated treatment improving patient outcomes. Further research needed elucidate molecular foster interdisciplinary collaboration.
Language: Английский
Citations
0
BMC Pulmonary Medicine, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 2, 2024
Abstract Background Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and bronchiectasis, present significant threats to global health. Recent studies have revealed the crucial role of lung microbiome in development these diseases. Pathogens evolved complex strategies evade immune response, with manipulation host cellular epigenetic mechanisms playing a pivotal role. There is existing evidence regarding effects Pseudomonas on modifications their association Therefore, this study aims directly assess connection between abundance We hope that our findings will shed light molecular behind pathogen infections. Methods analyzed data from 366 participants, including individuals COPD, acute exacerbations COPD (AECOPD), healthy individuals. Previous given limited attention impact groups comparison Two independent datasets different ethnic backgrounds were used for external validation. Each dataset separately bacteria at genus level. Results The reveals , bacterium, was consistently found high concentrations all but it very low datasets. This suggests may influence through epigenetics, contributing progression Conclusions emphasizes importance understanding relationship microbiome, onset disease. Enhanced recognition functions, along better concepts, can lead improved diagnosis treatment.
Language: Английский
Citations
3
Cancer Prevention Research, Journal Year: 2024, Volume and Issue: 17(9), P. 401 - 414
Published: May 24, 2024
Abstract Lung cancer is the second most prevalent worldwide and a leading cause of cancer-related deaths. Recent technological advancements have revealed that lung microbiome, previously thought to be sterile, host various microorganisms. The association between microbiome initiation, progression, metastasis complex contradictory. However, disruption in homeostasis compositions correlated with increased risk cancer. This review summarizes current knowledge about recent developments trends cancer–related microbiota or microbial components. article aims provide information on this rapidly evolving field while giving context general role In addition, briefly discussed causative We will mechanisms by which influence carcinogenesis, focusing dysbiosis. Moreover, we also discuss host–microbiome interaction as it plays crucial stimulating regulating immune response. Finally, diagnostic offer an overview predictive biomarker
Language: Английский
Citations
3
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 955, P. 176938 - 176938
Published: Oct. 15, 2024
Language: Английский
Citations
3
Cells, Journal Year: 2023, Volume and Issue: 12(24), P. 2801 - 2801
Published: Dec. 8, 2023
In recent years, there has been a growing interest in the relationship between microorganisms surrounding environment and cancer cells. While tumor microenvironment predominantly comprises cells, stromal immune emerging research highlights significant contributions of microbial cells to development progression. Although impact gut microbiome on treatment response lung is well established, investigations indicate complex roles microbiota cancer. This article focuses findings human its impacts We delve into characteristics influence development. Additionally, we explore intratumoral microbiome, metabolic interactions how microorganism-produced metabolites can contribute Furthermore, provide comprehensive review current literature implications for metastatic potential this discusses therapeutic modulation establish prevention strategies optimize treatment.
Language: Английский
Citations
6
Diagnostics, Journal Year: 2023, Volume and Issue: 13(19), P. 3157 - 3157
Published: Oct. 9, 2023
(1) Introduction: Although historically, the lung has been considered a sterile organ, recent studies through 16S rRNA gene sequencing have identified substantial number of microorganisms. The human microbiome an “essential organ,” carrying about 150 times more information (genes) than are found in entire genome. purpose present study is to characterize and compare three different interstitial diseases: idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis, nondifferential disease. (2) Material methods: This was prospective cohort where DNA 28 patients with ILD extracted from lavage then processed using standard technique RNA sequencing. In tertiary teaching hospital northern, western part Romania, samples were collected bronchoscopy processed. (3) Results: same four species all but quantities compositions: Firmicutes, Actinobacteria, Proteobacteria Bacteroides. Streptococcus most prevalent genus, followed by Staphylococcus Prevotella. Statistically significant differences OUT count for ten abundant taxa genus: Gemella, Prevotella, Neisseria, Haemophilus, Bifidobacterium. comparative analysis showed richer microbiota IPF, as shown alpha diversity index. (4) Conclusions: diseases, microorganisms normally reduced restricted flora dominated Firmicutes family. These changes significantly disrupt continuity observed bacterial pattern oropharynx bronchial tree lung, possibly impacting evolution severity diseases.
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6522 - 6522
Published: June 13, 2024
Recent advancements in stem cell biology and tissue engineering have revolutionized the field of neurodegeneration research by enabling development sophisticated vitro human brain models. These models, including 2D monolayer cultures, 3D organoids, organ-on-chips, bioengineered aim to recapitulate cellular diversity, structural organization, functional properties native brain. This review highlights how these models been used investigate effects various pathogens, viruses, bacteria, fungi, parasites infection, particularly cand their subsequent impacts on neurodegenerative diseases. Traditional studies demonstrated susceptibility different types elucidated mechanisms underlying pathogen-induced neuroinflammation, identified potential therapeutic targets. Therefore, current methodological improvement brought technology overcome challenges cells, such as limited incomplete microenvironment, lack morphological structures highlighting need for further technological advancements. underscored significance from model elucidating intricate dynamics pathogen infection modeling. enabled researchers unravel specific infections SARS-CoV-2 alter blood-brain-barrier function Toxoplasma gondii impacting neural morphology its function. Ultimately, hold promise personalized platforms drug compound, gene therapy, vaccine. Overall, we discussed recent progress applications studying infection-related neurodegeneration, future directions.
Language: Английский
Citations
1