Is Intestinal Cell Death in Necrotising Enterocolitis Assorted and Multifarious? A Special Focus on Risk Factors and Their Pathogenic Mechanisms DOI Creative Commons
Sri Harsha Kanuri, Newly Bagang,

Ayse Sena Ulucay

et al.

EMJ Gastroenterology, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 28, 2023

Necrotising enterocolitis (NEC) is a serious gastrointestinal clinical disorder primarily affecting preterm newborns. It characterised by wider histological spectrum, ranging from mild mucosal injury, microvascular thrombosis, and localised necrosis, to transmural intestinal necrosis. In the most severe form, it can be fatal, with complications such as perforation, peritonitis, sepsis. Medical management not clinically efficacious except in self-limiting cases, only focused on symptomatic treatment. Intestinal cell death regarded crucial nascent cellular event pathogenesis of NEC that leads leaky barrier, well local systemic inflammation. Therefore, events besiege should understood meticulous precise manner. This review provides an extensive overview different types NEC, including apoptosis, autophagy, necroptosis, pyroptosis. critically important helps us comprehend downstream signalling play vital role initiation progression disease NEC. Pertinent research studies performed this regard would unravel novel molecular targets could form basis for drafting innovative therapeutic agents optimising outcomes

Language: Английский

Unraveling the Molecular Mechanisms of SIRT7 in Angiogenesis: Insights from Substrate Clues DOI Open Access
Junjie Ma, Liqian Yang, Jiaxing Wu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11578 - 11578

Published: Oct. 28, 2024

Angiogenesis, a vital physiological or pathological process regulated by complex molecular networks, is widely implicated in organismal development and the pathogenesis of various diseases. SIRT7, member Sirtuin family nicotinamide adenine dinucleotide + (NAD+) dependent deacetylases, plays crucial roles cellular processes such as transcriptional regulation, cell metabolism, proliferation, genome stability maintenance. Characterized its enzymatic activities, SIRT7 targets an array substrates, several which exert regulatory effects on angiogenesis. Experimental evidence from vitro vivo studies consistently demonstrates modulating angiogenesis, mediated through mechanisms. Consequently, understanding role angiogenesis holds significant promise, offering novel avenues for therapeutic interventions targeting either This review delineates putative mechanisms regulates taking substrates clue, endeavoring to elucidate experimental observations integrating knowledge established angiogenenic

Language: Английский

Citations

0
Is Intestinal Cell Death in Necrotising Enterocolitis Assorted and Multifarious? A Special Focus on Risk Factors and Their Pathogenic Mechanisms DOI Creative Commons
Sri Harsha Kanuri, Newly Bagang,

Ayse Sena Ulucay

et al.

EMJ Gastroenterology, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 28, 2023

Necrotising enterocolitis (NEC) is a serious gastrointestinal clinical disorder primarily affecting preterm newborns. It characterised by wider histological spectrum, ranging from mild mucosal injury, microvascular thrombosis, and localised necrosis, to transmural intestinal necrosis. In the most severe form, it can be fatal, with complications such as perforation, peritonitis, sepsis. Medical management not clinically efficacious except in self-limiting cases, only focused on symptomatic treatment. Intestinal cell death regarded crucial nascent cellular event pathogenesis of NEC that leads leaky barrier, well local systemic inflammation. Therefore, events besiege should understood meticulous precise manner. This review provides an extensive overview different types NEC, including apoptosis, autophagy, necroptosis, pyroptosis. critically important helps us comprehend downstream signalling play vital role initiation progression disease NEC. Pertinent research studies performed this regard would unravel novel molecular targets could form basis for drafting innovative therapeutic agents optimising outcomes

Language: Английский

Citations

0
Is Intestinal Cell Death in Necrotising Enterocolitis Assorted and Multifarious? A Special Focus on Risk Factors and Their Pathogenic Mechanisms DOI Creative Commons
Sri Harsha Kanuri, Newly Bagang,

Ayse Sena Ulucay

et al.

EMJ Gastroenterology, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 28, 2023

Necrotising enterocolitis (NEC) is a serious gastrointestinal clinical disorder primarily affecting preterm newborns. It characterised by wider histological spectrum, ranging from mild mucosal injury, microvascular thrombosis, and localised necrosis, to transmural intestinal necrosis. In the most severe form, it can be fatal, with complications such as perforation, peritonitis, sepsis. Medical management not clinically efficacious except in self-limiting cases, only focused on symptomatic treatment. Intestinal cell death regarded crucial nascent cellular event pathogenesis of NEC that leads leaky barrier, well local systemic inflammation. Therefore, events besiege should understood meticulous precise manner. This review provides an extensive overview different types NEC, including apoptosis, autophagy, necroptosis, pyroptosis. critically important helps us comprehend downstream signalling play vital role initiation progression disease NEC. Pertinent research studies performed this regard would unravel novel molecular targets could form basis for drafting innovative therapeutic agents optimising outcomes

Language: Английский

Citations

0