Chitosan‐Based Hydrogels as Antibacterial/Antioxidant/Anti‐Inflammation Multifunctional Dressings for Chronic Wound Healing

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(30)

Published: July 22, 2024

Abstract Due to repeated microbial infection, persistent inflammation, excessive oxidative stress, and cell dysfunction, chronic wounds are difficult heal, posing a serious threat public health. Therefore, developing multifunctional wound dressings that can regulate the complex microenvironment of enhance cellular function holds great significance. Recently, chitosan has emerged as promising biopolymer for healing due its excellent biocompatibility, biodegradability, versatile bioactivity. The aim this review is provide comprehensive understanding mechanisms delayed discuss healing–promoting properties derivatives, such good antibacterial activity, hemostatic capacity, ability promote tissue regeneration. On basis, potential applications chitosan‐based hydrogels summarized in healing, including providing suitable microenvironment, eliminating bacterial infections, promoting hemostasis, inhibiting alleviating In addition, concerns perspectives clinical application also discussed.

Language: Английский

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Exosomes: The emerging mechanisms and potential clinical applications in dermatology

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(5), P. 1778 - 1795

Published: Jan. 1, 2024

Skin tissue, composed of epidermis, dermis, and subcutaneous is the largest organ human body.It serves as a protective barrier against pathogens physical trauma plays crucial role in maintaining homeostasis.Skin diseases, such psoriasis, dermatitis, vitiligo, are prevalent can seriously impact quality patient life.Exosomes lipid bilayer vesicles derived from multiple cells with conserved biomarkers important mediators intercellular communication.Exosomes skin cells, blood, stem main types exosomes that involved modulating microenvironment.The dysregulation exosome occurrence transmission, well alterations their cargoes, complex pathogenesis inflammatory autoimmune diseases.Therefore, promising diagnostic therapeutic targets for diseases.Importantly, exogenous exosomes, or play improving environment repairing damaged tissues by carrying various specific active substances involving variety pathways.In domain clinical practice, have garnered attention prospective agents including psoriasis vitiligo.Furthermore, investigations substantiated regenerative efficacy cell-derived repair.In this review, we mainly summarize latest studies about mechanisms applications dermatology, atopic systemic lupus erythematosus, sclerosis, diabetic wound healing, hypertrophic scar keloid, aging.This will provide novel perspective diagnosis treatment dermatosis.

Language: Английский

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Recent advances on application of polysaccharides in cosmetics

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 100004 - 100004

Published: Jan. 30, 2024

Natural products have attracted wide attention in the cosmetics market due to their safety and high efficiency. As a highly active substance nature, natural polysaccharides been reported recent years various cosmetic activities such as moisturizing, whitening, anti-aging repairing skin, are becoming hot research topic industry. At present, mechanism of polysaccharide exerting activity has widely studied, but relationship between polysaccharide's chemical structure not effectively analyzed, which leads limitation development. In this review, skin repair was introduced. The potential summarized by analyzing influence physical properties polysaccharides, extraction method, molecular weight, monosaccharide composition, functional group structural modification, etc., laid foundation for analysis improved its value.

Language: Английский

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Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 31, 2025

The orderly regulation of immune inflammation and promotion the regeneration skin vessels fibers are key to treatment diabetic injury (DSI). Although various traditional polypeptide biological dressings continue be developed, their efficacy is not satisfactory. In recent years, plant-to-mammal has provided an effective approach for chronic wound management, but development plant-based treatments remains challenging. exosomes from Chinese herbs promising healing. this study, plant derived lemons (Citrus limon) were extracted, was verified. Lemon regulated polarization reprogramming macrophages, promoted proliferation migration vascular endothelial cells fibroblasts, thus healing wounds. To solve problems continuous drug delivery penetration depth, Exosomes loaded into a hydrogel constructed Gelatin Methacryloyl (GelMA) Dialdehyde Starch (DAS) that closely fits skin, absorbs water, swells, moist breathable, effectively promoting sustained slow release resulting in excellent performance Our GelMA-DAS-Lemon (GelMA/DAS/Exo hydrogel) patch represents potentially valuable option repairing wounds clinical applications.

Language: Английский

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Recent progress of microneedles in transdermal immunotherapy: A review

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124481 - 124481

Published: July 23, 2024

Language: Английский

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Beyond the Needle: Innovative Microneedle-Based Transdermal Vaccination

Medicines, Journal Year: 2025, Volume and Issue: 12(1), P. 4 - 4

Published: Feb. 7, 2025

Vaccination represents a critical preventive strategy in the current global healthcare system, serving as an indispensable intervention against diverse pathogenic threats. Although conventional immunization relies predominantly on hypodermic needle-based administration, this method carries substantial limitations, including needle-associated fear, bloodborne pathogen transmission risks, occupational injuries among workers, waste management issues, and dependence trained medical personnel. Microneedle technology has emerged innovative vaccine delivery offering convenient, effective, minimally invasive administration. These microscale needle devices facilitate targeted antigen to epidermal dermal tissues, where abundant populations of antigen-presenting cells, specifically Langerhans dendritic provide robust immunological responses. Multiple research groups have extensively investigated microneedle-based vaccination strategies. This transdermal technique offers several advantages, notably circumventing cold-chain requirements enabling self-administration. Numerous preclinical investigations clinical trials demonstrated safety profile, immunogenicity, patient acceptance microneedle-mediated across applications. comprehensive review examines fundamental aspects immunization, principles, transcutaneous strategies, delivery-including classifications, barriers. Furthermore, addresses technical considerations, such treatment efficacy, application methodologies, wear duration, dimensional optimization, manufacturing processes, regulatory frameworks, sustainability followed by analysis future perspective technology.

Language: Английский

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Smart bandage with multi-sensor system for wound healing and microenvironment monitoring

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160509 - 160509

Published: Feb. 1, 2025

Language: Английский

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The Role of Keratinocytes in Skin Health and Disease

Dermatological Reviews, Journal Year: 2025, Volume and Issue: 6(2)

Published: March 24, 2025

ABSTRACT Aim This study aims to provide a comprehensive analysis of keratinocytes, the predominant cell type in epidermis, by examining their structural, functional, and regulatory roles skin biology. The explores intricate processes keratinocyte differentiation, proliferation, immune interactions, emphasizing essential contributions homeostasis, wound healing, barrier integrity. Additionally, it investigates involvement keratinocytes dermatological disorders such as psoriasis, atopic dermatitis, cancer, highlighting pathological alterations molecular mechanisms. Methods review covers broad range studies, including vitro vivo research on biology, interactions with growth factors, inflammatory responses skin. It also discusses therapeutic advancements biologics gene therapy that focus restoring function diseases. Results highlights play pivotal role inflammation regulation factors promote healing regeneration. Dysregulation is linked several diseases, need for targeted approaches. Recent treatments, biologics, offer promising outcomes managing conditions driven dysfunction. Conclusion primary aim this an in‐depth overview functions particularly health, inflammation, disease development. highlight latest strategies targeting treatment

Language: Английский

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All-in-one hydrogel patches with sprayed bFGF-loaded GelMA microspheres for infected wound healing studies

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124205 - 124205

Published: May 9, 2024

The current wound healing process faces numerous challenges such as bacterial infection, inflammation and oxidative stress. However, dressings used to promote healing, are not well suited meet the clinical needs. Hyaluronic acid (HA) only has excellent water absorption good biocompatibility but facilitates cell function tissue regeneration. Dopamine, on other hand, increases overall viscosity of hydrogel possesses antioxidant property. Furthermore, chitosan exhibits outstanding performance in antimicrobial, anti-inflammatory activities. Basic fibroblast growth factor (bFGF) is conducive proliferation migration, vascular regeneration healing. Hence, we designed an all-in-one patch containing dopamine framed by hyaluronic (HDC) with sprayed gelatin methacryloyl (GelMA) microspheres loaded bFGF (HDC-bFGF). adhesive, anti-inflammatory, antibacterial properties. In vitro experiments, HDC-bFGF showed significant inhibitory effect RAW Staphylococcus aureus (S. aureus) also effectively scavenged free radicals, addition promoting migration 3 T3 cells. mice acute infected model, adhered surface greatly accelerated via its activities, inhibition pro-vascularization effects. Therefore, multifunctional holds great promise for application.

Language: Английский

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Bioactive lipids in the skin barrier mediate its functionality in health and disease

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 260, P. 108681 - 108681

Published: June 17, 2024

Our skin protects us from external threats including ultraviolet radiation, pathogens and chemicals, prevents excessive trans-epidermal water loss. These varied activities are reliant on a vast array of lipids, many which unique to skin, that support physical, microbiological immunological barriers. The cutaneous physical barrier is dependent specific lipid matrix surrounds terminally-differentiated keratinocytes in the stratum corneum. Sebum- keratinocyte-derived lipids cover skin's surface regulate microbiota. Meanwhile, signal between resident infiltrating immune cells, driving inflammation its resolution response other threats. Lipids particular importance include ceramides, crucial for corneum formation therefore functionality, fatty acids, contribute acidic pH microbiota, as well matrix, bioactive metabolites these involved cell signalling, inflammation, numerous processes. diverse complex maintain homeostasis healthy implicated diseases, unrelated systemic conditions with manifestations, processes such ageing. also gut-skin axis, signalling two sites. Therefore, provide valuable resource exploration processes, local disease development progression, accessible biomarker discovery disease, an opportunity fully understand relationship host Investigation could diagnostic prognostic biomarkers, help identify new targets interventions. Development improvement existing vitro silico approaches explore lipidome, advances lipidomics technologies, will facilitate ongoing progress research.

Language: Английский

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