BCG vaccination is associated with longitudinal changes in systemic eicosanoid levels in elderly individuals: A secondary outcome analysis DOI Creative Commons

Pavan Kumar Nathella,

Chandrasekaran Padmapriyadarsini,

Arul Nancy

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32643 - e32643

Published: June 1, 2024

We investigated how BCG vaccination affects the levels of certain eicosanoids, namely Leukotriene B4, 15-epimer LXA4, prostaglandin F2, Lipoxin A4, Prostaglandin E2 and Resolvin D1 in plasma healthy elderly individuals (aged 60–80) before vaccination, one month post-vaccination (M1), six months (M6). This study is part clinical trial "BCG Vaccine Study: Reducing COVID-19 Impact on Elderly Indian Hotspots," registered registry (NCT04475302). While some primary outcomes have been previously reported, this analysis delves into immunological outcomes. Our findings indicate that leads to reduced 15-epi-LXA4, PGE2, at both M1 M6. In contrast, there a notable increase circulating LTB4 these time points following vaccination. underscores immunomodulatory effects hints its potential modulate immune responses by dampening inflammatory reactions.

Language: Английский

An Update on Anti-COVID-19 Vaccines and the Challenges to Protect Against New SARS-CoV-2 Variants DOI Creative Commons
Fábio Mambelli, Ana Carolina V. S. C. de Araujo, Jéssica Pires Farias

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(1), P. 23 - 23

Published: Jan. 1, 2025

The COVID-19 pandemic has posed a significant threat to global health systems, with extensive impacts across many sectors of society. been responsible for millions deaths worldwide since its first identification in late 2019. Several actions have taken prevent the disease, including unprecedented fast development and vaccination campaigns, which were pivotal reducing symptoms deaths. Given impact pandemic, continuous changes virus, present vaccine technologies, this review analyzes how, so far, we met challenge by emergence new variants discusses how next-generation pan-coronavirus vaccines, enhanced longevity breadth immune responses, may be tackled alternative administration routes antigen delivery platforms. By addressing these critical aspects, aims contribute ongoing efforts achieve long-term control COVID-19, stimulating discussion work on vaccines capable facing future waves infection.

Language: Английский

Citations

2
The Yin and Yang of TLR4 in COVID-19 DOI
Suprabhat Mukherjee, Jagadeesh Bayry

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

6
Coronavirus Disease Pathophysiology: Biomarkers, Potential New Remedies, Comorbidities, Long COVID-19, Post Pandemic Epidemiological Surveillance DOI Open Access
Jacek Z. Kubiak, Małgorzata Kloc

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12236 - 12236

Published: July 31, 2023

The toughest challenge modern biomedical research ever faced was the rapid understanding of SARS-CoV-2 physiopathology [...].

Language: Английский

Citations

6
BCG vaccination is associated with longitudinal changes in systemic eicosanoid levels in elderly individuals: A secondary outcome analysis DOI Creative Commons

Pavan Kumar Nathella,

Chandrasekaran Padmapriyadarsini,

Arul Nancy

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32643 - e32643

Published: June 1, 2024

We investigated how BCG vaccination affects the levels of certain eicosanoids, namely Leukotriene B4, 15-epimer LXA4, prostaglandin F2, Lipoxin A4, Prostaglandin E2 and Resolvin D1 in plasma healthy elderly individuals (aged 60–80) before vaccination, one month post-vaccination (M1), six months (M6). This study is part clinical trial "BCG Vaccine Study: Reducing COVID-19 Impact on Elderly Indian Hotspots," registered registry (NCT04475302). While some primary outcomes have been previously reported, this analysis delves into immunological outcomes. Our findings indicate that leads to reduced 15-epi-LXA4, PGE2, at both M1 M6. In contrast, there a notable increase circulating LTB4 these time points following vaccination. underscores immunomodulatory effects hints its potential modulate immune responses by dampening inflammatory reactions.

Language: Английский

Citations

0