Cellular and Molecular Biology, Journal Year: 2023, Volume and Issue: 69(7), P. 66 - 70
Published: July 31, 2023
Language: Английский
IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: June 19, 2024
The intricate involvement of macrophages in pulmonary emphysema signifies their pivotal role disease pathogenesis and progression. Dysregulated macrophage behavior, marked by altered activation states, promotes chronic inflammation, protease release, oxidative stress, exacerbating tissue damage alveolar destruction. Targeting emerges as a promising therapeutic avenue to modulate immune responses, restore homeostasis, mitigate severity. Recent advances have highlighted heterogeneity, signaling pathways, impact on lung remodeling. Understanding the complexities offers insights into novel strategies potential interventions aimed at modulating behavior halt Future prospects involve precision therapies, multi-target approaches, comprehensive studies validate efficacy safety macrophage-targeted interventions, paving way for transformative management emphysema.
Language: Английский
Citations
0
Cells, Journal Year: 2024, Volume and Issue: 13(18), P. 1581 - 1581
Published: Sept. 20, 2024
Background: Despite promise in preclinical models of acute respiratory distress syndrome (ARDS), mesenchymal stem cells (MSC) have failed to translate therapeutic benefit clinical trials. The MSC is a live cell medicine and interacts with the patient’s disease state. Here, we explored this interaction, seeking devise strategies enhance function. Methods: Human bone-marrow-derived MSCs were exposed lung homogenate from healthy E. coli-induced ARDS rat models. Apoptosis functional assays performed. Results: model showed reduced arterial oxygenation, decreased compliance an inflammatory microenvironment compared controls. underwent more apoptosis after stimulation by controls coli, which may explain why persist longer subjects administration. Changes expression surface markers cytokines associated different groups. anti-microbial effects did not change stimulation. Moreover, conditioned media lung-homogenate-stimulated inhibited T-cell proliferation. Conclusions: These findings suggest that plays important role MSC’s mechanism action, changes can inform modulate MSC-based therapy for ARDS.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 8, 2024
Due to the vital importance of lungs, lung-related diseases and their control are very important. Severe inflammatory responses mediated by immune cells were among leading causes lung tissue pathology damage during COVID-19 pandemic. In addition, uncontrolled cell can lead in other infectious non-infectious diseases. It is essential a way that leads homeostasis. Immunosuppressive drugs only suppress do not affect homeostasis reactions. The therapeutic application mesenchymal stem (MSCs), addition restoring homeostasis, promote regeneration through production growth factors differentiation into cells. However, communication between MSCs after treatment pulmonary essential, investigating this help develop clinical perspective. Different studies phase showed reverse fibrosis, increase regeneration, airway remodeling, reduce tissue. proliferation potential one mechanisms effects. Furthermore, they secrete exosomes function change function. Another important mechanism harmful with innate adaptive cells, which shift system toward regulatory hemostatic responses.
Language: Английский
Citations
0
Regenerative Medicine, Journal Year: 2015, Volume and Issue: 18(12), P. 913 - 934
Published: Oct. 1, 2015
This review explores the intricate relationship between acute respiratory distress syndrome (ARDS) and Type II diabetes mellitus (T2DM). It covers ARDS epidemiology, etiology pathophysiology, along with current treatment trends challenges. The lipopolysaccharides (LPS) role in its association non-communicable diseases COVID-19 are discussed. highlights therapeutic potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) for T2DM, emphasizing their immunomodulatory effects. also underlines how T2DM exacerbates pathophysiology discusses hUC-MSCs modulating immune responses. In conclusion, multidisciplinary approach to managing focusing on inflammation, oxidative stress therapy future.
Language: Английский
Citations
2
Cellular and Molecular Biology, Journal Year: 2023, Volume and Issue: 69(7), P. 66 - 70
Published: July 31, 2023
Language: Английский
Citations
0