Effect of First Long Term Training on Platelet Function in Thoroughbreds DOI Open Access
Arianna Miglio, Emanuela Falcinelli, Katia Cappelli

et al.

Published: Dec. 11, 2023

Training has a significative effect on physiology of blood coagulation both in humans and horses. Several hemostatic changes have been reported after exercise the horse but data available are inconclusive. The aim this study was to investigate platelet activation primary platelet-related hemostasis modifications young untrained Thoroughbred racehorses first 4-month timeframe incremental training period order improve knowledge topic. Twenty-nine clinically healthy, untrained, 2-year-old racehorses. Never trained Thoroughbreds were followed during their sprint schedule. Blood collection performed once month (T-30, T0, T30, T60, T90). Platelet aggregation measured by light transmission aggregometer response various agonists: adenosine diphosphate (ADP), collagen calcium ionophore A23187. function evaluated using Function Analyzer (PFA-100®) collagen/ADP collagen/adrenaline cartridges. Nitrite-nitrate (NOx) plasma concentrations colorimetric assay assess vivo nitric oxide bioavailability. investigated also through gene expression analyses (selectin P-SELP, ectonucleotidase CD39-ENTPD1, prostaglandin I2 synthase-PTGIS, endothelial synthase 3-NOS3). Differences among time points analyzed mean±SEM calculated. Significant identified compared with T-30 increase (collagen:32.6±4.8 vs 21.6±4.9%; ADP: 35.5±2.0 24.5±3.1%; A23187: 30±4.7 23.8±4%) shorter closure C-ADP cartridges (75.6±4.4 87.7±3.4 sec) that tended return baseline value at T90. NOx significantly increased 30 days program baseline. long-term induce hyperactivity already Thoroughbreds. Regular physical blunts negative effects acute efforts platelets activation.

Language: Английский

Association of Physical Activity in Different Domains with All-Cause and Cause-Specific Mortality in Chronic Kidney Disease: A US Population-Based Cohort Study DOI
Pengfei He, Jiao Zhang, Jian Pan

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Glycated Hemoglobin Level and Body Mass Index Correlation with Peripheral Artery Disease in Patients with Type 2 Diabetes Mellitus at Waled Hospital, Cirebon, Indonesia DOI Creative Commons

Tania Auliya,

Nihayatul Amaliyah,

Menik Herdwiyanti

et al.

GHMJ (Global Health Management Journal), Journal Year: 2024, Volume and Issue: 7(4), P. 235 - 244

Published: Dec. 11, 2024

Background: Peripheral Artery Disease (PAD) is a condition that reduces blood flow to the lower extremities and primarily caused by atherosclerosis. PAD one of complications Diabetes Mellitus (DM). Diabetics have an 11.6 times more likely develop than those without diabetes. Glycated haemoglobin (HbA1c) levels >7% are at higher risk chronic complications. Obesity overweight also raise developing disease. However, research on correlation between Body Mass Index (BMI) remains unclear controversial. Aims: To analyze HbA1c BMI with incidence in patients type 2 Waled Hospital. Methods: This analytical observational study cross-sectional design. Data was collected diagnosed Internal Medicine Clinic Hospital June - July 2024. A total sample 77 obtained using consecutive sampling. The inclusion criteria were DM, aged 19-60 years, medical record data equipped for least last 3 months prior collection. exclusion history diabetic ulcers, amputation limb disability, Acute Coronary Syndrome, stroke, kidney failure, recurrent anaemia, transfusions months. Primary gathered through ABI examination, while secondary from records. analysed Spearman test. Results: Patients had poor control (51.9%), moderate (29.9%) good (18.2%), majority normal (39%) followed obese I (22.1%), II (16.9%). Our showed distribution severe (0%), (3.9%), mild (44.2%), (46.8%), arteriosclerotic (5.2%). test p-0.789 (p> 0.05) p- 0.653 (p>0.05) PAD. Conclusion: There no association glycated hemoglobin or values Hospital, Cirebon, Indonesia. Received: 25 September 2024 | Reviewed: 21 October Revised: 30 November Accepted: 11 December

Language: Английский

Citations

0
Higher frequency of fish intake and healthy lifestyle behaviors may be associated with a lower platelet count in Japan: Implication for the anti-atherosclerotic effect of fish intake DOI Creative Commons
Shigemasa Tani,

Wataru Atsumi,

Tsukasa Yagi

et al.

Preventive Medicine, Journal Year: 2023, Volume and Issue: 175, P. 107682 - 107682

Published: Aug. 23, 2023

Habitual fish intake and healthier lifestyles are associated with a lower risk of atherosclerotic cardiovascular disease (ASCVD). Higher platelet counts (PLCs) reportedly higher ASCVD events. We aimed to investigate the association between lifestyle PLCs.We conducted cross-sectional study in cohort 9329 participants (average age: 46.9 ± 12.9 years; 58.9% men) no history registered at Health Planning Center Nihon University Hospital 2019.The average frequency was 2.15 1.28 days/week. As increased (0, 1, 2, 3, 4, 5, 6, 7 days), PLC decreased significantly (p < 0.0001). Multivariable logistic regression analysis showed that tended be determinant PLC. Aerobic exercise habits sleep duration were independent negative determinants Cigarette smoking positive Furthermore, increasing frequency, proportion habitual aerobic exercise, non-smoking habits, longer 0.0001 for all). n-3 polyunsaturated fatty acid (n-3 PUFA), calculated based on data from Japanese National Nutrition Survey, PLC.Higher behaviors may comprehensively PLCs. The N-3 PUFA anti-inflammatory effects, rich fish, also related This explain preventive effects risk.

Language: Английский

Citations

1
Effect of First Long Term Training on Platelet Function in Thoroughbreds DOI Open Access
Arianna Miglio, Emanuela Falcinelli, Katia Cappelli

et al.

Published: Dec. 11, 2023

Training has a significative effect on physiology of blood coagulation both in humans and horses. Several hemostatic changes have been reported after exercise the horse but data available are inconclusive. The aim this study was to investigate platelet activation primary platelet-related hemostasis modifications young untrained Thoroughbred racehorses first 4-month timeframe incremental training period order improve knowledge topic. Twenty-nine clinically healthy, untrained, 2-year-old racehorses. Never trained Thoroughbreds were followed during their sprint schedule. Blood collection performed once month (T-30, T0, T30, T60, T90). Platelet aggregation measured by light transmission aggregometer response various agonists: adenosine diphosphate (ADP), collagen calcium ionophore A23187. function evaluated using Function Analyzer (PFA-100®) collagen/ADP collagen/adrenaline cartridges. Nitrite-nitrate (NOx) plasma concentrations colorimetric assay assess vivo nitric oxide bioavailability. investigated also through gene expression analyses (selectin P-SELP, ectonucleotidase CD39-ENTPD1, prostaglandin I2 synthase-PTGIS, endothelial synthase 3-NOS3). Differences among time points analyzed mean±SEM calculated. Significant identified compared with T-30 increase (collagen:32.6±4.8 vs 21.6±4.9%; ADP: 35.5±2.0 24.5±3.1%; A23187: 30±4.7 23.8±4%) shorter closure C-ADP cartridges (75.6±4.4 87.7±3.4 sec) that tended return baseline value at T90. NOx significantly increased 30 days program baseline. long-term induce hyperactivity already Thoroughbreds. Regular physical blunts negative effects acute efforts platelets activation.

Language: Английский

Citations

1