Association of Red Blood Cell Distribution Width With Carotid–Femoral Pulse Wave Velocity in a Southern Chinese Population

Journal of Clinical Hypertension, Journal Year: 2025, Volume and Issue: 27(1)

Published: Jan. 1, 2025

Red blood cell distribution width (RDW) has recently been recognized as a novel biomarker associated with various cardiovascular conditions. This study aims to investigate the relationship between RDW and carotid-femoral pulse wave velocity (cfPWV) in southern Chinese population. A total of 4916 patients were initially enrolled from First Affiliated Hospital Fujian Medical University January 2016 December 2022. Based on criteria inclusion exclusion, 2830 included this study. Body weight, height, pressure measured, clinical biochemical tests recorded. cfPWV was assessed using non-invasive automatic device. Spearman's correlation analysis, generalized linear regression multivariable logistic regression, stratified analysis conducted assess cfPWV. Participants into four subgroups based quartiles: Q1 (RDW ≤ 12.80%), Q2 (12.80% < 13.40%), Q3 (13.40% 14.10%), Q4 > 14.10%). significant increase age, systolic pressure, cfPWV, HbA1c levels observed higher quartiles. Both revealed association Specifically, compared lowest quartile, risk cfPWV≥10 m/s increased by 56% highest quartile (odds ratio = 1.564, p 0.001). persisted particularly among elderly, hypertensive who not taking medication, those medication but had poor control. The plasma level significantly population, older adults individuals hypertension, suggesting potential marker for arterial stiffness.

Language: Английский

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The Association between Red Blood Cell Distribution Width and Mortality Risk after Hip Fracture: A Meta-Analysis

Medicina, Journal Year: 2024, Volume and Issue: 60(3), P. 485 - 485

Published: March 14, 2024

Background and Objectives: Hip fractures in the elderly pose a considerable health risk cause concern. Red blood cell distribution width (RDW) is valuable marker for identifying patients at high of age-related mortality various disorders diseases. However, its association with poor patient outcomes following hip has yet to be fully established. Hence, purpose this meta-analysis was investigate gain better understanding relationship between RDW levels after fractures. Materials Methods: PubMed, Embase, Web Science, other databases were comprehensively searched until April 2023 identify relevant studies. The included observational studies finding admission or preoperation short-term long-term rates results presented terms odds ratios (ORs) hazard (HRs) corresponding 95% confidence intervals (CIs). Results: This 10 involving 5834 Patients preoperative over 14.5% had higher risks 1-year (OR: 5.40, CI: 1.89–15.48, p = 0.002) 3-month 2.91, 1.42–5.95, 0.004) mortality. Higher significantly associated an 11% 1 year (HR: 1.11, 1.06–1.17, < 0.00001). 6-month mortality, which three times that those lower 3.00, 1.60–5.61, 0.0006). correlated 30-day 6.44, 3.32–12.47, Conclusions: Greater values before surgery Because can easily measured using routine test low cost, parameter promising as indicator

Language: Английский

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Red cell distribution width/platelet ratio estimates the 3-year risk of decompensation in Metabolic Dysfunction-Associated Steatotic Liver Disease-induced cirrhosis

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(7), P. 685 - 704

Published: Feb. 21, 2024

BACKGROUND For compensated advanced chronic liver disease (cACLD) patients, the first decompensation represents a dramatically worsening prognostic event. Based on event (DE), transition to decompensated (dACLD) can occur through two modalities referred as acute (AD) and non-AD (NAD), respectively. Clinically Significant Portal Hypertension (CSPH) is considered strongest predictor of in these patients. However, due its invasiveness costs, CSPH almost never evaluated clinical practice. Therefore, recognizing non-invasively predicting tools still have more appeal across healthcare systems. The red cell distribution width platelet ratio (RPR) has been reported be an indicator hepatic fibrosis Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). predictive role for explored. AIM In this observational study, we investigated usage RPR DEs MASLD-related cACLD METHODS Fourty controls 150 MASLD-cACLD patients were consecutively enrolled followed up (FUP) semiannually 3 years. At baseline, biochemical, clinical, Stiffness Measurement (LSM), Child-Pugh (CP), Model End-Stage (MELD), aspartate aminotransferase/platelet count index (APRI), Fibrosis-4 (FIB-4), Albumin-Bilirubin (ALBI), ALBI-FIB-4, collected. During FUP, (timing modalities) recorded. was assessed at baseline DE occurrence according available Clinical Practice Guidelines. RESULTS Of 43 (28.6%) progressed dACLD median time 28.9 months (29 NAD 14 AD). Baseline values significantly higher comparison controls, well MELD, CP, APRI, FIB-4, ALBI, LSM dACLD-progressing compared individuals [all P < 0.0001, except FIB-4 (P : 0.007) ALBI 0.011)]. Receiving operator curve analysis revealed > 0.472 0.894 best cut-offs prediction respectively 3-year DE, superiority other non-invasive examined. 0.02) presence baseline-CSPH 0.04) independently associated with DE. Patients presenting showed risk 0.0023). CONCLUSION Altogether findings suggest valid potentially applicable tool timing

Language: Английский

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Association between red blood cell indices and non-alcoholic fatty liver disease: Prospective study and two-sample Mendelian randomization analysis based on large cohorts

Annals of Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 101775 - 101775

Published: Jan. 1, 2025

Non-alcoholic fatty liver disease (NAFLD) is the primary contributor to persistent chronic which derives cardiovascular disease, malignancies, and related mortality. There an association between red blood cell (RBC) indices incidence of NAFLD, but causal relationship has not been determined. We aimed investigate through prospective Mendelian randomization (MR) analyses. The study involved 237,016 participants from UK Biobank. employed Cox proportional hazard models restricted cubic spline assess RBC index used two-sample MR analysis identify any causality. Over a mean follow-up 8.64 years, 2,894 Biobank developed NAFLD. showed significant associations high levels hemoglobin (HGB) (hazard ratio [HR], 1.41; 95% confidence intervals [CI] 1.24-1.60; P < 0.001), count (HR, 1.20; CI, 1.07-1.36; P=0.003) increased risk indicated HGB NAFLD (Odds [OR], 1.55; 1.11-2.18; P=0.010). However, there was no observed This demonstrated positive can predict potentially be as large-scale non-invasive tool dynamically monitor occurrence development

Language: Английский

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Extracellular Traps in Inflammation: Pathways and Therapeutic Targets

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 627 - 627

Published: April 8, 2025

New roles for immune cells, overcoming the classical cytotoxic response, have been highlighted by growing evidence. The such as neutrophils, monocytes/macrophages, and eosinophils, are versatile cells involved in release of web-like DNA structures called extracellular traps (ETs) which represent a relevant mechanism these prevent microbes’ dissemination. In this process, many enzymes, elastase, myeloperoxidase (MPO), microbicidal nuclear granule proteins, contribute to clearance entrapped microorganisms after binding, involved. However, an overproduction ETs can cause unwanted dangerous effects host, resulting several pathological manifestations, among chronic inflammatory disorders, autoimmune diseases, cancer, diabetes. review, we discuss mechanisms double-edged sword role both physiological contexts. addition, evaluated some possible strategies target aimed at either preventing their formation or degrading existing ones.

Language: Английский

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The red blood cell distribution width is associated with all-cause and cardiovascular mortality among individuals with non-alcoholic fatty liver disease

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321789 - e0321789

Published: April 17, 2025

Background Identifying reliable prognostic indicators is essential for the appropriate management of non-alcoholic fatty liver disease (NAFLD). Red blood cell distribution width (RDW) has been established as an inflammatory marker associated with cardiovascular outcomes. This study aimed to evaluate association between RDW and both all-cause mortality in individuals NAFLD. Methods Data from 7,438 participants NAFLD were analyzed, collected 2005 2016 through National Health Nutrition Examination Survey (NHANES). Mortality data retrieved Death Index (NDI). Restricted cubic spline (RCS) analysis was used illustrate relationship risk, Weighted Cox proportional hazards models assess independent risk. Receiver operating characteristic (ROC) curves generated predictive ability survival Results During a median follow-up period 124 months, 1,269 deaths recorded, including 335 causes. positively correlated according RCS analysis. Participants categorized into quartiles based on levels. Those highest quartile (Q4) demonstrated significantly higher risk (HR 3.61, 95% confidence interval [CI]:2.17–6.02, P=0.009) 2.29, CI:1.72–3.06, P < 0.0001), weighted models. Additionally, area under curve (AUC) at 3, 5 10 years was, 0.69, 0.67, 0.66, respectively. For mortality, AUCs 0.70, 0.68, Conclusion Among patients NAFLD, identified predictor increased

Language: Английский

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Risk analysis of the association between red blood cell distribution width-to-peripheral oxygen saturation ratio and poor prognosis in critical patients with obstructive sleep apnea

Respiratory Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 108120 - 108120

Published: April 1, 2025

Language: Английский

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Association Between Red Cell Distribution Width and Erectile Dysfunction: A Cross-Sectional Study Using NHANES 2001–2004 Data

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 104536 - 104536

Published: May 1, 2025

Language: Английский

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Beyond anemia: Red cell distribution width as a universal biomarker in contemporary medicine

Journal of Hematology and Allied Sciences, Journal Year: 2025, Volume and Issue: 0, P. 1 - 10

Published: May 19, 2025

Red cell distribution width (RDW), traditionally employed as a parameter for classifying anemia, has undergone remarkable transformation in clinical medicine to emerge powerful prognostic biomarker across an extensive spectrum of pathological conditions. This comprehensive review meticulously examines RDW’s extraordinary evolution from its conventional role hematology current standing versatile indicator with broad applicability. A significant advantage RDW is automatic calculation by modern automated analyzers part routine complete blood counts, rendering it exceptionally accessible and cost-effective settings worldwide. The complex pathophysiological mechanisms linking elevated various disease states involve sophisticated interactions between inflammatory cascades, oxidative stress pathways, nutritional deficiencies, bone marrow dysfunction, metabolic dysregulations. growing body evidence supporting utility extends multiple medical specialties, including cardiovascular medicine, hepatology, gastroenterology, endocrinology, pulmonology, infectious diseases, rheumatology, neurology, nephrology, oncology. Despite demonstrated applicability, challenges standardization interpretation persist, necessitating further research. Future investigative directions are focused on establishing disease-specific thresholds, integrating into existing risk prediction models, elucidating the molecular that connect elevation processes. As our understanding continues deepen, demonstrates exceptional promise developing personalized approaches monitoring prognostication, firmly position invaluable tool contemporary practice.

Language: Английский

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Association between red cell distribution width-to-albumin ratio and prognostic outcomes in pediatric intensive care unit patients: a retrospective cohort study

Frontiers in Pediatrics, Journal Year: 2024, Volume and Issue: 12

Published: March 6, 2024

This study aimed to assess the association between Red Cell Distribution Width-to-Albumin Ratio (RAR) and clinical outcomes in Pediatric Intensive Care Unit (PICU) patients.

Language: Английский

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