Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
Language: Английский
Exploration of Targeted Anti-tumor Therapy, Journal Year: 2023, Volume and Issue: unknown, P. 812 - 849
Published: Sept. 28, 2023
From attributing mutations to cancers with the advent of cutting-edge genetic technology in recent decades, re-searching age-old theory intrinsic metabolic shift (Warburg’s glycolysis), quest for a precise panacea mainly metastatic cancers, remains incessant. This review delineates advanced glycation end product (AGE)-receptor AGE (RAGE) pathway driven intricate oncogenic cues, budding from (glycolytic) reliance tumour cells, branching into emergence malignancies. Strong AGE-RAGE concomitance metastasis, chemo-resistance and cancer resurgence adversely incite disease progression patient mortality. At conjunction are “glycolytically” generated AGEs AGE-activated RAGE, instigating aberrant molecular pathways, culminating aggressive as by-products insurgence, modify metabolome, epigenome microbiome, besides coercing inter-, intra- extra-cellular micro-milieu conducive events like epithelial-mesenchymal transition (EMT). synergistically elicit ATP surge surplus energy, autophagy apoptotic evasion chemo-resistance, insulin-like growth factor 1 (IGF-1) meta-inflammation angiogenesis, high mobility group box-1 (HMGB1) immune tolerance, S100 proteins p53 protein attenuation suppression. pronouncedly reported invasive forms breast, prostate, colon pancreatic higher patients than healthy counterparts, stage localized phase. Hence, investigation person-specific presence AGEs, soluble RAGE can be advocated impending bio-markers diagnostic, prognostic therapeutic purposes, predict risk diabetes, obesity, syndrome well general population, monitor prognosis metastasis cancer, reckon complications survivors. Furthermore, clinical reports exogenous (dietary) endogenous (internally formed) patients, contemporary trials involving axis underlined theranostic implications.
Language: Английский
Citations
16
Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 6, 2025
Prostate cancer (PCa) is a common and serious health issue among older men globally. Metabolic reprogramming, particularly involving lactate mitochondria, plays key role in PCa progression, but studies linking these factors to prognosis are limited. To identify novel prognostic markers of based on lactate-mitochondria-related genes (LMRGs), RNA sequencing data clinical information from The Cancer Genome Atlas (TCGA) the cBioPortal database were used construct risk signature. Here, we established nine-LMRG signature for PCa, Kaplan-Meier curves confirmed worse high-risk subgroups TCGA dataset. Meanwhile, nomogram that effectively predicts patients was also constructed. Next, close associations between immune microenvironment examined clarify LMRGs shaping landscape. Furthermore, as only lactate-related gene nine genes, myeloperoxidase (MPO) identified factor mediates production vitro vivo through attenuation glycolytic pathway. More importantly, MPO significantly inhibited cell migration, invasion, epithelial-mesenchymal transition (EMT), indicating its potential an anticancer gene. Additionally, with high expression highly sensitive chemotherapeutic agents mitochondrial inhibitors, highlighting improved therapeutic strategy management.
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 180 - 180
Published: Jan. 24, 2025
The Connexin43 transmembrane protein (Cx43), encoded by the GJA1 gene, is a member of multigenic family proteins that oligomerize to form hemichannels and intercellular channels, allowing gap junctional communication between adjacent cells or intracellular extracellular compartments. Cx43 has long been shown play significant but complex role in cancer development, acting as tumor suppressor and/or promoter. effects are associated with both channel-dependent -independent functionalities differ depending on expression level, subcellular location considered stage progression. Recently, six isoforms have described one them, called GJA1-20k, also found be expressed cells. This isoform generated alternative translation corresponds end part fourth domain entire carboxyl-terminal (CT) domain. Initial studies cardiac model implicated GJA1-20k trafficking full-length plasma membrane, cytoskeletal dynamics mitochondrial fission distribution. As these processes progression, potential link functions, activity can postulated this context. review synthetizes current knowledge its involvement related epithelial-to-mesenchymal transition (EMT) proliferation, dissemination quiescence Particular emphasis placed putative roles exportation functions originally attributed CT
Language: Английский
Citations
0
Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(10)
Published: Oct. 10, 2023
RNA polymerase mitochondria (POLRMT) is essential for mitochondrial transcription machinery and other functions. Its expression potential functions in prostate cancer were explored here. The Cancer Genome Atlas cohort (TCGA PRAD) shows that POLRMT mRNA upregulated tissues upregulation correlated with poor patients' survival. protein levels local different primary/immortalized cells. Genetic depletion of POLRMT, using viral shRNA or CRISPR/Cas9 gene editing methods, impaired cells, leading to depolarization, oxidative stress, complex I inhibition, ATP depletion. Moreover, resulted robust inhibition cell viability, proliferation, migration, provoked apoptosis. Conversely, contents strengthened following ectopic overexpression. In vivo, intratumoral injection adeno-associated virus impeded xenograft growth nude mice. silencing, detected shRNA-treated tissues. IMT1 (inhibitor 1), the first-in-class inhibitor, inhibited vitro vivo. Together, overexpressed an important growth, representing a novel promising diagnostic therapeutic oncotarget.
Language: Английский
Citations
5
Genes & Nutrition, Journal Year: 2024, Volume and Issue: 19(1)
Published: May 27, 2024
Mitochondrial respiration complexes play a crucial function. As result, dysfunction or change is intimately associated with many different diseases, among them cancer. The epigenetic, evolutionary, and metabolic effects of mitochondrial complex IΙ are the primary concerns our review. Provides novel insight into vital role naringenin (NAR) as an intriguing flavonoid phytochemical in cancer treatment. NAR significant that member flavanone group polyphenols mostly present citrus fruits, such grapefruits, well other fruits vegetables, like tomatoes cherries, foods produced from medicinal herbs. evidence now available indicates NAR, herbal remedy, has pharmacological qualities anti-cancer effects. Through variety mechanisms, including induction apoptosis, cell cycle arrest, restriction angiogenesis, modulation several signaling pathways, prevents growth However, hydrophobic crystalline structure primarily responsible for its instability, limited oral bioavailability, water solubility. Furthermore, there no targeting high rate breakdown acidic environment. These shortcomings barriers to efficient medical application. Improvement ΙΙ by loading it on chitosan nanoparticles promising strategy.
Language: Английский
Citations
1
Journal of Cellular Immunology, Journal Year: 2023, Volume and Issue: 5(3), P. 57 - 64
Published: Sept. 27, 2023
Oxidative phosphorylation dysregulation (OXPHOS) has been demonstrated to be essential for the development of cancer. Therefore, it may argued that chaperone and deacetylase activities modulate OXPHOS activity. For instance, a complicated network interactions connects cell’s bioenergetic features neoplastic potential through imbalance sirtuin 3 (SIRT3) succinate dehydrogenase (SDH) enzymatic activity in mitochondria. The studies outlined this review indicate targeting SDH regulators is promising novel therapeutic strategy extremely resistant disease. Additionally, viable involve triggering cell death mechanism cancer cells by blocking mitochondrial metabolism with natural substance. A naturally occurring flavonoid called naringenin (NAR) extensively investigated its pharmacological properties, which include anti-tumor actions. However, due low bioavailability situation, nanoencapsulation designed improve NAR anticancer efficacy. can encapsulated chitosan nanoparticles-TPP conjugates, thereby improving cellular absorption cytotoxicity against cells. Consequently, we proposed nanoparticles as target
Language: Английский
Citations
1
Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: March 13, 2024
Non-coding ribonucleic acids (ncRNAs) have been recently shown to contribute tumorigenesis by mediating changes in metabolism. ncRNAs act as key molecules metabolic pathways regulation. The dysregulation of during cancer progression contributes altered phenotypes leading reprogrammed Since affect different tumor processes regulating mitochondrial dynamics and metabolism, the future can be exploited disease detection, diagnosis, treatment, resistance. purpose this review is highlight role reprogramming relate their therapeutic potential management genitourinary cancer.
Language: Английский
Citations
0
JCO Precision Oncology, Journal Year: 2024, Volume and Issue: 8
Published: July 1, 2024
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 85 - 106
Published: Sept. 13, 2024
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 18, 2024
ABSTRACT Purpose To examine the effects of voluntary exercise training on tumor growth and explore underlying intratumoral molecular pathways processes responsible for beneficial VWR initiation progression in a mouse model Castration-Resistant Prostate Cancer (CRPC). Methods Male immunodeficient mice (SCID) were castrated subcutaneously inoculated with human CWR-22RV1 cancer cells to construct CRPC xenograft before randomly assigned either wheel running (VWR) or sedentary (SED) group (n=6/group). After three weeks, tissues collected. Tumor size was measured calculated. mRNA expression markers DNA replication, Androgen Receptor (AR) signaling, mitochondrial dynamics determined by RT-PCR. Protein content western blotting. Finally, RNA-sequencing analysis performed tissues. Results Voluntary resulted smaller volume at initial stage attenuated throughout time course (P < 0.05). The reduction coincided lower replication ( MCM2 , MCM6 MCM7 ), AR signaling ELOVL5 FKBP5 ) regulatory proteins fission (Drp1 Fis1) fusion (MFN1 OPA1) when compared SED (P<0.05). More importantly, RNA sequencing data further revealed that related angiogenesis, extracellular matrix formation endothelial cell proliferation downregulated. Conclusions Three weeks effective delaying progression, which reduced transcription targets dynamics. We identified pathways/processes angiogenesis may be delayed VWR.
Language: Английский
Citations
0