Российский физиологический журнал им И М Сеченова, Journal Year: 2024, Volume and Issue: 110(10), P. 1541 - 1558
Published: Dec. 29, 2024
This abstract discusses the oligomerization of G protein-coupled receptors (GPCRs), which significantly expands functional capabilities cells in living organisms by modulating intracellular signaling pathways. provides a variety physiological effects both normal and pathological states. The structure localization brain one most studied heterodimers, D1-D2 receptor complex, its cascades, correlate with development depressive disorders, are examined. Sexual differences functioning this heterodimer analyzed, issue selectivity bivalent synthetic ligands activating specific pathways is discussed, highlighting their potential as therapeutic targets for targeted treatment disorders. concluding part addresses diversity dopamine heterodimers other members GPCR family role pathophysiology depression.
Language: Английский