Targeting SMAD3 Improves Response to Oxaliplatin in Esophageal Adenocarcinoma Models by Impeding DNA Repair DOI Open Access
Farah Ballout, Heng Lu, Nadeem S. Bhat

et al.

Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 30(10), P. 2193 - 2205

Published: April 9, 2024

TGFβ signaling is implicated in the progression of most cancers, including esophageal adenocarcinoma (EAC). Emerging evidence indicates that a key factor development resistance toward cancer therapy.

Language: Английский

H2AX: A key player in DNA damage response and a promising target for cancer therapy DOI Open Access

Kirti S. Prabhu,

Shilpa Kuttikrishnan,

Nuha Ahmad

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116663 - 116663

Published: April 30, 2024

Cancer is caused by a complex interaction of factors that interrupt the normal growth and division cells. At center this process intricate relationship between DNA damage cellular mechanisms responsible for maintaining genomic stability. When not repaired, it can cause genetic mutations contribute to initiation progression cancer. On other hand, response system, which involves phosphorylation histone variant H2AX (γH2AX), crucial in preserving integrity signaling facilitating repair double-strand breaks. This review provides an explanation molecular dynamics context response. It emphasizes role recruiting localizing machinery at sites chromatin damage. The explains how phosphorylation, facilitated master kinases ATM ATR, acts as signal damage, triggering downstream pathways govern cell cycle checkpoints, apoptosis, fate decision death. critical regulatory point, ensuring survival promoting or steering cells towards apoptosis cases catastrophic Moreover, we explore therapeutic potential targeting cancer treatment, leveraging its dual function biomarker target. By delineating lead roles control, highlight significance both prognostic tool focal point intervention, offering insights into utility enhancing efficacy treatments.

Language: Английский

Citations

43
Unveiling the pharmacological potential of plant triterpenoids in breast cancer management: an updated review DOI Creative Commons
Shaza H. Aly, Abdullah M. M. Elbadry, Ahmed S. Doghish

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Language: Английский

Citations

14
Molecular Basis of Breast Tumor Heterogeneity DOI
Esra Dikoglu, Fresia Pareja

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 237 - 257

Published: Jan. 1, 2025

Language: Английский

Citations

1
Role of LncRNA H19 in tumor progression and treatment DOI Creative Commons
Linjing Li, Yuting Gao, Boyi Yu

et al.

Molecular and Cellular Probes, Journal Year: 2024, Volume and Issue: 75, P. 101961 - 101961

Published: April 8, 2024

As one of the earliest discovered lncRNA molecules, H19 is usually expressed in large quantities during embryonic development and involved cell differentiation tissue formation. In recent years, role tumors has been gradually recognized. Increasing evidence suggests that its aberrant expression closely related to cancer development. LncRNA as an oncogene not only promotes growth, proliferation, invasion metastasis many tumors, but also develops resistance treatment, affecting patients' prognosis survival. Therefore, this review, we summarise extensive research on involvement tumor progression discuss how H19, a key target gene, affects sensitivity radiotherapy, chemotherapy immunotherapy by participating multiple cellular processes regulating signaling pathways, which provides promising prospect for further into treatment cancer.

Language: Английский

Citations

8
DNA damage response in breast cancer and its significant role in guiding novel precise therapies DOI Creative Commons
Jiayi Li,

Ziqi Jia,

Dong Lin

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 27, 2024

Abstract DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer recent years. On hand, DDR coordinates cell cycle and signal transduction, whose dysfunction may lead to apoptosis, genomic instability, tumor development. Conversely, is an intrinsic feature tumors that underlies their treatments inflict damage. In this review, we systematically explore various mechanisms DDR, rationale research advances DDR-targeted drugs cancer, discuss challenges its clinical applications. Notably, poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated favorable efficacy safety with high homogenous recombination (HRD) status a series trials. Moreover, several studies on novel DDR-related molecules are actively exploring target become resistant PARP inhibition. Before further application new regimens or drugs, standardized biomarkers needed develop for accurately characterizing benefit population predicting efficacy. Despite promising treatments, off-target toxicity drug resistance need be addressed. Strategies overcome await exploration mechanisms, combined targeted immunotherapy will hopefully provide more precise strategies expand potential responsive populations.

Language: Английский

Citations

7
Factors affecting the cleavage efficiency of the CRISPR-Cas9 system DOI Creative Commons

Won Jun Jung,

Soo-Ji Park, Seongkwang Cha

et al.

Animal Cells and Systems, Journal Year: 2024, Volume and Issue: 28(1), P. 75 - 83

Published: March 3, 2024

The CRISPR-Cas system stands out as a promising genome editing tool due to its cost-effectiveness and time efficiency compared other methods. This has tremendous potential for treating various diseases, including genetic disorders cancer, promotes therapeutic research wide range of diseases. Additionally, the simplifies generation animal models, offering more accessible alternative traditional CRISPR-Cas9 can be used cleave target DNA strands that need corrected, causing double-strand breaks (DSBs). with DSBs then recovered by repair pathway uses edit gene sequences. High cleavage is thus imperative effective editing. Herein, we explore several factors affecting system. These include GC content protospacer-adjacent motif (PAM) proximal distal regions, single-guide RNA (sgRNA) properties, chromatin state. considerations contribute

Language: Английский

Citations

6
RSK1 and RSK2 as therapeutic targets: an up-to-date snapshot of emerging data DOI Creative Commons

Ashley N. Spirrison,

Deborah A. Lannigan

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Dec. 4, 2024

Introduction The four members of the p90 ribosomal S6 kinase (RSK) family are serine/threonine protein kinases, which phosphorylated and activated by ERK1/2. RSK1/2/3 further PDK1. Receiving inputs from two major signaling pathways places RSK as a key node in numerous pathologies. A plethora RSK1/2 substrates have been identified, majority cases causative roles these play pathology unknown.

Language: Английский

Citations

4
Dual Functionality of Cobalt Oxide Nanoparticles: Exploring Their Potential as Antimicrobial and Anticancer Agents DOI
Ikhazuagbe H. Ifijen,

Emmanuel Faderin,

C. O. OKAFOR

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

0
Vernonia amygdalina Delile and cancer: a comprehensive review of its chemopreventive mechanisms and efficacy DOI Creative Commons
Martin Ndayambaje, Thierry Habyarimana,

Theogene Niyonsaba

et al.

Discover Plants., Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 30, 2025

Language: Английский

Citations

0
Sustainable Strategies for Cancer Phytomedicine: Balancing Efficacy and the Environment Responsibility DOI

Sibel Sari,

Demet Saylan

Published: Jan. 1, 2025

Language: Английский

Citations

0