Life Sciences, Journal Year: 2024, Volume and Issue: 350, P. 122784 - 122784
Published: June 5, 2024
Language: Английский
Pharmacological Research, Journal Year: 2023, Volume and Issue: 197, P. 106978 - 106978
Published: Nov. 1, 2023
Animal venom is an important evolutionary innovation in nature. As one of the most representative animal venoms, scorpion contains extremely diverse set bioactive peptides. Scorpion peptides not only are 'poisons' that immobilize, paralyze, kill, or dissolve preys but also become candidates for drug development and design. Here, review focuses on molecular diversity peptides, their typical structural characteristics, multiple therapeutic pharmaceutical applications channelopathies, viral infections cancers. Especially, group toxin TRPTx targeting transient receptor potential (TRP) channels systematically summarized worthy attention because TRP play a crucial role regulation homeostasis occurrence diseases human. We further establish relationship between characteristics functional to provide research basis modern clinical utilization resources.
Language: Английский
Citations
24
Life Sciences, Journal Year: 2024, Volume and Issue: 347, P. 122653 - 122653
Published: April 23, 2024
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3651 - 3651
Published: April 12, 2025
Micropeptides (miPEPs), encoded by short open reading frames (sORFs) within various genomic regions, have recently emerged as critical regulators of multiple biological processes. In particular, these small molecules are now increasingly being recognized for their role in modulating viral replication, pathogenesis, and host immune responses. Both miPEPs virus-derived been noted ability to regulate virus–host interactions through diversified mechanisms such altering protein stability protein–protein interactions. Although thousands sORFs annotated having the potential encode miPEPs, only a number experimentally validated so far, with some directly linked subset associated modulation, indicating that investigation is still its infancy. The systematic identification, translational status assessment, in-depth characterization, functional analysis substantial fraction encoding remain largely underexplored. Further studies anticipated uncover intricate underlying interactions, broader functions miPEPs. This article will review emerging roles immunity, discuss challenges future perspectives miPEP studies.
Language: Английский
Citations
0
Exploration of Medicine, Journal Year: 2025, Volume and Issue: 6
Published: April 28, 2025
The interaction between cancer and coronavirus disease 2019 (COVID-19) poses significant challenges, particularly for immunocompromised individuals who are at heightened risk acute infections long-term complications. pandemic has exacerbated existing vulnerabilities in care by disrupting treatment protocols delaying diagnoses, leading to worsened health outcomes. This article emphasizes the importance of investigating potential impact severe respiratory syndrome 2 (SARS-CoV-2) on progression highlights need effective strategies protect this high-risk population. Long-term consequences, including emergence long COVID, further emphasize ongoing surveillance comprehensive healthcare planning patients during after pandemics. A multifaceted approach is essential, incorporating vaccination, timely therapeutic interventions, sustained support with lingering symptoms. also discusses urges continued research into oncogenic risks associated SARS-CoV-2, which crucial enhancing our understanding broader implications COVID-19 informing public aimed safeguarding future Moreover, data collection development refined clinical guidelines vital improving patient outcomes preparing systems crises. Additionally, mechanisms SARS-CoV-2 may increase susceptibility, chronic inflammation, cellular senescence, immune dysregulation. Understanding these elucidating virus’s potential, among survivors infections. Ensuring continuity resilience global crises requires mitigate disruptions, enhance access screenings treatments, address specific challenges faced experiencing COVID.
Language: Английский
Citations
0
American Journal Of Pathology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 3, 2024
Abstract As a major component of innate immunity and positive regulator interferons, the Stimulator interferon gene (STING) has an immunotherapy potential to govern variety infectious diseases. Despite recent advances regarding vaccines against COVID-19, nontoxic novel adjuvants with enhance vaccine efficacy are urgently desired. In this connection, it been well-documented that STING agonists applied combat COVID-19. This approach is significance for boosting immune responses most likely through autophagy-dependent manner in susceptible individuals infection induced by severe acute respiratory syndrome Coronavirus (SARS‑CoV‑2). Given exert substantial immunomodulatory impacts under wide array pathologic conditions, these agents could be considered enhancing immunogenicity SARS-related coronavirus. Here, we intend discuss agonists’ recruitment boost upon vaccination coronavirus infections. light primordial role autophagy modulation, being antiviral adjuvant was also explored.
Language: Английский
Citations
3
Biomolecules, Journal Year: 2023, Volume and Issue: 13(10), P. 1452 - 1452
Published: Sept. 26, 2023
In light of the COVID-19 global pandemic caused by SARS-CoV-2, ongoing research has centered on minimizing viral spread either stopping entry or inhibiting replication. Repurposing antiviral drugs, typically nucleoside analogs, proven successful at virus This review summarizes current information regarding coronavirus classification and characterization presents broad clinical consequences SARS-CoV-2 activation angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types. It provides publicly available knowledge chemical nature proposed therapeutics their target biomolecules to assist identification potentially new drugs for treatment infection.
Language: Английский
Citations
3
Open Forum Infectious Diseases, Journal Year: 2023, Volume and Issue: 10(10)
Published: Sept. 8, 2023
What Long COVID Prevention Strategies Suggest About Its Pathophysiology bVaccination defined as 14 days after (1) second dose of mRNA-1273 or BNT162b2 (2) first shot Ad26.c Vaccination was among those the CoronaVac BNT162b2.d with mRNA vaccine (BNT162b2 mRNA-1273) AZD1222.e any following: mRNA-1273, BNT162b2, Ad26.f Type not specified.
Language: Английский
Citations
2
Journal of Investigative Dermatology, Journal Year: 2024, Volume and Issue: 144(3), P. 441 - 443
Published: Feb. 21, 2024
View Large Image Figure ViewerDownload Hi-res image Download (PPT) The widespread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has given rise to COVID-19 and its devastating consequences. Research studies report frequent dermatological manifestations, with at least 20% of patients having cutaneous lesions (Magro et al., 2021Magro C. Nuovo G. Mulvey J.J. Laurence J. Harp Crowson A.N. skin as a critical window in unveiling the pathophysiologic principles COVID-19.Clin Dermatol. 2021; 39: 934-965Abstract Full Text PDF PubMed Scopus (22) Google Scholar). Reports this population note wide range vasculitis, including small vessel also known leukocytoclastic vasculitis (LCV)."The implication LC3B, LC3C, LL-37 COVID-19-associated vasculopathies could open novel avenues therapeutic targets." "The Gawaz 2024Gawaz A. Schindler M. Hagelauer E. Blanchard Riel S. Vollert al.SARS-CoV-2-induced vasculitic are associated massive spike protein depositions autophagosomes.J Invest 2024; 144: 369-377.e4Abstract (0) Scholar recently reported new data investigating mechanisms vascular injury potential causality SARS-CoV-2 lesions. From cohort 4 positive for LCV, compared 3 controls without disease, investigators characterized microvascular changes samples COVID-19–induced vasculitis. To explore mechanism investigate direct viral presence skin, they performed histological analyses ultrastructural characterization endothelial cells. Interestingly, found extensive deposition cells that colocalized autophagosome proteins LC3B LC3C—markers autophagy. researchers concluded autophagosomes occurs during SARS-CoV-2–associated vasculitis.Clinical Implications•This study provides insight into connection between lesions.•It spells out evidence relating virus manifestations.•It demonstrates COVID-19–associated targets. •This 1.8% all findings (Kaya 2020Kaya Kaya Saurat J.H. Clinical histopathological features pathological COVID-19: review literature.Dermatopathology (Basel). 2020; 7: 3-16Crossref Scholar), is type small-vessel by inflammation blood vessels. Often an immune response, various factors can trigger it, infections drugs. Immune complex aggregates postcapillary venules, infiltration polymorphonuclear cells, fibrinoid necrosis, leukocytoclasis histologically characterize LCV. vasculopathy true on histology develops minority cases, mostly or (Maronese 2022Maronese C.A. Zelin Avallone Moltrasio Romagnuolo Ribero al.Cutaneous era pandemic.Front Med (Lausanne). 2022; 9996288Google pathogenic not fully elucidated. Although role hyperactive complement activation, question, it appears result from due pauci-immune thromboembolic mechanisms. Previous beliefs attributed damage infection. However, recent research suggests indirect may be involved pathogenesis vasculopathy, low cell expression angiotensin-converting enzyme (ACE2) resistance SARS CoV-2 analysis electron microscopy capillaries. They inflammatory pattern were similar closely simulated pathology classical observed vasocentric lymphohistiocytic neutrophilic infiltrates, nuclear dust, erythrocyte extravasation, capillary wall degeneration fibrin deposition. surface (S) mediates entry fulfill function, S binds receptor ACE2 through binding domain activated human proteases, allowing infect cell. have detection particles sweat glands (Cazzato 2022Cazzato Cascardi Colagrande Foti Stellacci Marrone al.SARS-CoV-2 skin: insights perspectives.Biomolecules. 12: 1212Crossref (9) still uncertain whether attributable consequence circulating other organs leading Magro glycoproteins interalveolar septa 5 cases. microvasculature suggesting both eccrine authors (Gawaz Scholar) did detect microscopy. observe abundant cytoplasm in/around nucleus dermal date, there no real active replication most endothelium, despite localization capsid protein, specifically vessels Neutrophils one effective defense against external pathogens; play important pathogen clearance specific antiviral NETosis, form death primarily caused neutrophils, creation extracellular neutrophil traps (NETs). NETs composed DNA fibers chromatin encapsulate cytosolic granule histones depolymerized reticulated trap eliminate pathogens (Zhang 2023Zhang R. Sun Han Y. Huang L. Sheng H. Wang al.Neutrophil autophagy NETosis perspectives.Autophagy. 2023; 19: 758-767Crossref (3) Autophagy—the conserved autodegradation process neutrophils—plays phagocytosis pathogens. Autophagy catabolic isolates damaged cellular components well invasive microbes, isolating them rest cell, forming autophagosomes, delivering lysosomes degradation. This eukaryotic essential survival, homeostasis, immunity (Resnik 2023Resnik Lopez Mingorance F. Rivera Mitchell Gonzalez C.D. Vaccaro M.I. response SARS-CoV-2.Int J Mol Sci. 24: 4928Crossref viruses affect metabolism pathways. leads accumulation metabolites infected marker microtubule-associated (LC3B). LC3 plays crucial overall process. acts RNA-binding causes mRNA interference Different tissues types ubiquitously express LC3B. Researchers implicated which expressed lower levels, virus-induced formation (Delorme-Axford Klionsky, 2020Delorme-Axford Klionsky D.J. Highlights fight does infection?.Autophagy. 16: 2123-2127Crossref (24) focused LC3C—protein markers autophagy—to determine LC3-associated setting was more prominent areas vascular-associated whereas LC3C evident directly than healthy where neither nor detectable any perivascular structures. cathelicidin antimicrobial peptide belongs family host peptides. Neutrophilic granulocytes release LL-37, innate activity. Some elevated plasma levels cases clinical hypercoagulation manifestations (Duan 2022Duan Z. Zhang Chen X. Liu Zhao Jin al.Role thrombotic complications COVID-19.Cell Life 79: 309Crossref (10) predominantly present rather nonrelated therefore SARS-CoV-2–related might endothelia. In Aloul 2022Aloul K.M. Nielsen J.E. Defensor E.B. Lin J.S. Fortkort J.A. Shamloo al.Upregulating prevent responses reduce microthrombosis.Front Immunol. 13880961Crossref (14) Scholar, highlighted helps vitro endocytosis dendritic aggregation. Furthermore, suggested enhancing potentially mitigate reactions related decrease incidence microthrombosis. previous virus-dependent immune-mediated COVID-19–related yet clearly identified molecular pathways responsible COVID-19. concept autophagosome-associated SARS-CoV2 proteins. These contribute better understanding virus-associated vasculopathy. targets (Figure 1). should exercise caution owing sample size studied timing investigations, late course disease. We need further prospective larger cohorts confirm these findings. Nesrine Brahimi: http://orcid.org/0009-0007-0799-852X Vincent Piguet: http://orcid.org/0000-0001-6079-4517 VP personal financial ties pharmaceutical company. He undertakes advisory work Pfizer, AbbVie, Janssen, UCB, Novartis, Almirall, Celgene. received honoraria Kyowa Kirin. his Department Division Director Dermatology University Toronto, departmental support Bausch Health, Celgene, LEO Pharma, Lilly, NAOS, Pierre-Fabre, Sanofi past 36 months. NB fellowship funding AbbVie Canada Grants. No preparation commentary. SARS-CoV-2–Induced Vasculitic Skin Lesions Are Associated Massive Spike Protein Depositions AutophagosomesJournal Investigative DermatologyVol. 144Issue 2PreviewIn 2, vasculopathic prognosis. conclusively clarified. study, 25 prospectively collected examined and, case analyzed immunohistochemistry. Vasculopathy 76% Full-Text Open Access
Language: Английский
Citations
0
Life Sciences, Journal Year: 2024, Volume and Issue: 350, P. 122784 - 122784
Published: June 5, 2024
Language: Английский
Citations
0