International Journal of Health Science,
Journal Year:
2024,
Volume and Issue:
4(11), P. 2 - 9
Published: Jan. 24, 2024
Objective:
investigate
and
analyze,
through
scientific
literature,
the
pathophysiological
mechanisms
underlying
Post-Traumatic
Stress
Disorder(PTSD),
in
addition
to
identifying
possible
targets
therapeutic
methods
for
effective
treatment
of
condition
Methods:
Narrative
literature
review
carried
out
from
September
November
2023,
searches
PubMed
database
using
search
strategy((Post-Traumatic
Disorders)
OR
(PTSD))
AND
((Treatment)
(Psychedelics)
(Neuromodulation)
(Virtual
Reality)
(Augmented
Reality)).2029
articles
were
found
and,
after
inclusion
exclusion
criteria,
17
selected
compose
study.Discussion:
Different
types
studies
point
influence
neuronal
circuits
PTSD,
demonstrating
reductions
connectivity
between
prefrontal
cortex
subcortical
structures,
such
as
amygdala
hippocampus.These
brain
changes
are
related
emotional
memory
symptoms
that
characterize
or
PTSD.Therefore,
psychotherapies,
cognitive
behavioral
therapy,
functional
release
technique
trauma-focused
associated
with
pharmacological
serotonin
reuptake
inhibitors
have
proven
be
treating
disorder.Innovative
neuromodulation
treatments
also
shown
important
results.Final
considerations:
It
is
essential
continue
develop
research
deepen
understanding
PTSD
provide
individualized
options
patients.Advancement
this
field
improve
quality
life
people
affected
by
ultimately,
achieve
more
complete
treatments.
Issues in Mental Health Nursing,
Journal Year:
2023,
Volume and Issue:
44(10), P. 1020 - 1034
Published: Oct. 3, 2023
This
narrative
review
explores
the
transformative
impact
of
Artificial
Intelligence
(AI)
on
mental
health
nursing,
particularly
in
enhancing
psychiatric
patient
care.
AI
technologies
present
new
strategies
for
early
detection,
risk
assessment,
and
improving
treatment
adherence
health.
They
also
facilitate
remote
monitoring,
bridge
geographical
gaps,
support
clinical
decision-making.
The
evolution
virtual
assistants
AI-enhanced
therapeutic
interventions
are
discussed.
These
technological
advancements
reshape
nurse-patient
interactions
while
ensuring
personalized,
efficient,
high-quality
addresses
AI's
ethical
responsible
use
emphasizing
privacy,
data
security,
balance
between
human
interaction
tools.
As
applications
care
continue
to
evolve,
this
encourages
continued
innovation
advocating
implementation,
thereby
optimally
leveraging
potential
nursing.
Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(7), P. 2630 - 2644
Published: June 20, 2023
Abstract
Post-traumatic
stress
disorder
(PTSD)
is
usually
considered
a
psychiatric
upon
emotional
trauma.
However,
with
the
rising
number
of
conflicts
and
traffic
accidents
around
world,
incidence
PTSD
has
skyrocketed
along
traumatic
brain
injury
(TBI),
complex
neuropathological
disease
due
to
external
physical
force
also
most
common
concurrent
PTSD.
Recently,
overlap
between
TBI
increasingly
attracting
attention,
as
it
potential
stimulate
emergence
novel
treatments
for
both
conditions.
Of
note,
exploiting
microRNAs
(miRNAs),
well-known
class
small
non-coding
RNAs
(ncRNAs),
have
rapidly
gained
momentum
in
many
nervous
system
disorders,
given
miRNAs’
multitudinous
key
regulatory
role
various
biological
processes,
including
neural
development
normal
functioning
system.
Currently,
wealth
studies
elucidated
similarities
pathophysiology
symptoms;
however,
there
dearth
discussion
respect
miRNAs
TBI.
In
this
review,
we
summarize
recent
available
discuss
highlight
promising
therapeutics
conditions
future.
BMC Psychology,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Jan. 11, 2025
In
clinical
practice,
creative
arts
therapy
is
frequently
utilized
for
the
treatment
of
traumatized
adults,
with
reports
favorable
outcomes.
However,
effectiveness
this
intervention
in
post-traumatic
stress
disorder
(PTSD)
has
not
yet
been
definitively
established
through
meta-analysis.
meta-analysis,
we
aim
to
assess
management
PTSD.
We
conducted
systematic
literature
searches
electronic
databases
from
extended
inception
each
database
November
2023.
Cochrane
risk
bias
tool
evaluate
quality
evidence.
Standardized
mean
differences
(SMDs)
were
calculated
as
effects
art
on
improvement
Seven
controlled,
comparative
studies
investigated
use
treating
adults
Meta-analysis
demonstrated
a
significant
decrease
PTSD
symptoms
following
(SMD
=
-1.98,
95%
Confidence
Interval
(CI):
-3.8
-0.16,
p
<
0.03,
I2
98%).
Subgroup
analysis
indicates
that
drama
was
notably
effective,
while
music,
art,
and
dance/movement
therapies
exhibited
less
pronounced
effects.
Despite
limitations,
including
limited
number
studies,
participant
size,
study
heterogeneity,
methodological
quality,
these
results
provide
valuable
understanding
regarding
efficacy
highlight
urgent
need
additional
research
area.
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Despite
advancements
in
psychiatric
treatments,
many
patients
with
treatment-resistant
disorders
are
turning
to
neurosurgical
interventions.
These
include
neuromodulation-based
surgeries
such
as
deep
brain
stimulation
(DBS)
and
ablative
cingulotomy,
offering
relief
for
severe
conditions
post-traumatic
stress
disorder
(PTSD),
depression,
schizophrenia,
obsessive-compulsive
(OCD),
anxiety,
substance
use
disorder.
While
"psychosurgery"
has
sparked
debate
due
concerns
about
patient
well-being,
recent
studies
indicate
promising
symptom
improvement
rates
across
various
while
also
demonstrating
overall
safety.
Neuromodulation
techniques,
DBS,
transcranial
magnetic
(TMS),
electroconvulsive
therapy
(ECT),
have
evolved
regard
their
sensitivity
ability
target
specific
regions
alleviate
symptoms.
benefits,
these
therapies
been
shown
elicit
side
effects
memory
loss
seizures
patients,
which
controversy
the
of
this
technology
clinicians
patients.
Ablative
therapies,
on
other
hand,
concerning
being
overly
invasive
approach
toward
care.
stigma
associated
interventions
care,
procedures
often
remain
a
last
resort
highlighting
need
continued
research
improve
treatments
expand
options
those
need.
In
narrative
review,
we
examine
current
literature
an
understanding
history
treatment
its
implications
clinical
practice.
Frontiers in Psychiatry,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 21, 2025
Introduction
Many
people
with
eating
disorders
report
having
experienced
childhood
maltreatment
or
a
traumatic
event
prior
to
developing
an
disorder.
Although
many
have
significant
exposure
symptoms
of
post-traumatic
stress
disorder,
very
little
research
has
examined
the
effects
combined
treatments
for
this
group.
The
purpose
systematic
review
was
synthesize
all
existing
on
biological
those
and
psychological
trauma,
evaluate
their
safety,
identify
future
areas
in
area
support
patients
trauma.
Method
A
multi-step
literature
search,
according
priori
protocol
performed
PubMed,
Embase,
APA
PsycINFO,
Web
Science,
Scopus
Cochrane
Central.
Studies
needed
include
intervention
at
least
one
disorder
trauma
outcome.
Given
limited
area,
minimal
exclusion
criteria
were
applied.
quality
assessment
included
studies
completed
using
Risk
Bias
Non-Randomized
Studies-or
Interventions
(ROBINS-I)
tool.
Results
After
removing
duplicates,
2623
article
titles
abstracts
screened,
43
articles
selected
full-text
review.
Following
review,
11
met
inclusion
criteria.
repurposed
medications
(n
=
3),
ketamine
2),
repetitive
transcranial
magnetic
stimulation
(rTMS;
n
deep
brain
=1)
electroconvulsive
therapy
(ECT;
1),
3,4-methylenedioxymethamphetamine
(MDMA;
neurofeedback
1).
All
reported
some
improvement
either
pathology,
strongest
effect
MDMA.
While
promising,
missing
data
selective
reporting
interpretability
findings.
Adverse
events
across
interventions
common.
Conclusion
is
common
disorders,
few
been
evaluated
population.
Future
work
should
aim
investigate
co-occurring
as
these
evolving
show
potential
benefits
complex
Psychotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: March 5, 2025
Exposure
to
family
violence
in
childhood
significantly
increases
the
risk
of
developing
severe
psychiatric
and
physiological
illnesses.
Trauma-focused
cognitive
behavioural
therapy
(TF-CBT)
effectively
addresses
trauma-related
symptoms
improves
overall
well-being.
However,
knowledge
persistence
these
positive
effects
over
time,
facilitating
factors,
why
some
children
are
not
benefited
remains
limited.
Furthermore,
little
attention
has
been
paid
exploring
children's
subjective
experiences.
This
study
aimed
investigate
long-term
changes
among
youths
who
underwent
TF-CBT
due
violence.
Nine
participants
(M
age
=
16,6
years,
range
14-23;
7
girls
2
boys)
were
assessed
interviewed
four
five
years
after
treatment.
The
adopted
a
mixed-method
approach,
integrating
quantitative
qualitative
methods.
While
most
still
reported
being
affected
by
violence,
had
from
treatment,
with
improvements
lasting
years.
for
those
did
report
decreased
symptoms,
trauma
persisted,
accompanied
additional
mental
health
problems.
findings
underscore
importance
providing
effective
trauma-focused
treatments
such
as
highlight
need
enhanced
safety
measures
parental
interventions
do
benefit
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Abstract
Background
Post-Traumatic
Stress
Disorder
(PTSD)
is
associated
with
neurobiological
alterations,
which
can
be
examined
using
surface-based
morphology
(SBM).
While
machine
learning
(ML)
approaches
have
shown
potential
in
classifying
PTSD
based
on
SBM
features,
further
exploration
needed
to
improve
interpretability
and
clinical
relevance.
Objectives
This
study
seeks
integrate
ML-based
classification
of
SHAP
analysis
identify
important
features
their
associations
symptomatology,
providing
insights
into
the
structural
changes
underlying
PTSD.
Methods
High-resolution
T1-weighted
MRI
data
from
101
participants
(62
PTSD,
39
healthy
controls)
were
analyzed
FreeSurfer’s
pipeline,
extracting
cortical
thickness,
surface
area,
curvature
aparc.a2009s
atlas.
Several
ML
models,
including
Random
Forest,
SVM,
XGBoost,
trained
evaluated
ten-fold
cross-validation.
was
applied
determine
feature
importance,
correlation
analyses
conducted
examine
relationships
between
key
symptom
severity.
Results
Sixteen
regions
identified
significant
differences
reduced
thickness
left
lingual
gyrus
increased
bilateral
central
sulcus.
The
Forest
model
achieved
highest
accuracy
(91%)
classification.
highlighted
parahippocampal
as
features.
Correlation
suggested
links
these
specific
clusters.
Conclusion
integration
interpretable
methods
provides
a
promising
approach
for
investigating
brain
validation
needed,
findings
contribute
better
understanding
neurobiology
may
support
future
research
diagnostic
therapeutic
strategies.