Brain Communications, Journal Year: 2023, Volume and Issue: 6(1)
Published: Dec. 28, 2023
Abstract Neurological disorders include a variety of conditions, including Alzheimer’s disease, motor neuron disease and Parkinson’s affecting longevity quality life, their pathogenesis is associated with oxidative stress. Several the chronic neurodegenerative pathologies CNS share some common features, such as stress, inflammation, synapse dysfunctions, protein misfolding defective autophagia. Neuroinflammation can involve activation mast cells, contributing to in addition other sources reactive oxygen species. Antioxidants powerfully neutralize species free radicals, decreasing damage. Antioxidant genes, like manganese superoxide dismutase enzyme, undergo epigenetic changes that reduce expression, thus increasing stress tissue. Alternatively, DNA be altered by radical The landscape these genes change antioxidant function may result disease. This imbalance production increases cause cell damage neurons often observed an age-related event. Increased expression mice protective against exogenous supplementation antioxidants. Manganese requires for its enzymic function. therapy considered diseases, new mimetic dismutase, avasopasem manganese, described suggested putative treatment causes aim this narrative review explore evidence role inhibiting Can neuronal environment causing neuroinflammation neurodegeneration, reduced or reversed?
Language: Английский
Citations
115CoQ10 and Mitochondrial Dysfunction in Alzheimer’s Disease
Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 191 - 191
Published: Feb. 2, 2024
The progress in understanding the pathogenesis and treatment of Alzheimer’s disease (AD) is based on recognition primary causes disease, which can be deduced from knowledge risk factors biomarkers measurable early stages disease. Insights into time course biomarker abnormalities point to a role for connection amyloid beta (Aβ) pathology, tau mitochondrial dysfunction, oxidative stress onset development AD. Coenzyme Q10 (CoQ10) lipid antioxidant electron transporter transport system. availability activity CoQ10 crucial proper function cellular bioenergetics. Based hypothesis AD stress, regulation efficiency phosphorylation system by means considered promising restoring impaired AD, or preventing dysfunction pathology This review summarizes pathophysiology may play significant role, with aim evaluating perspective pharmacotherapy its analogues.
Language: Английский
Citations
13Neurodegenerative Disease: From Molecular Basis to Therapy
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 967 - 967
Published: Jan. 12, 2024
Neurodegenerative diseases are a heterogeneous group of age-related disorders characterised by the progressive degeneration or death neurons in central peripheral nervous system [...].
Language: Английский
Citations
11Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties
Phytomedicine, Journal Year: 2023, Volume and Issue: 122, P. 155150 - 155150
Published: Oct. 15, 2023
Language: Английский
Citations
12Novel Therapeutic Strategies in Alzheimer’s Disease: Pitfalls and Challenges of Anti-Amyloid Therapies and Beyond
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3098 - 3098
Published: May 25, 2024
Alzheimer's disease (AD) causes a significant challenge to global healthcare systems, with limited effective treatments available. This review examines the landscape of novel therapeutic strategies for AD, focusing on shortcomings traditional therapies against amyloid-beta (Aβ) and exploring emerging alternatives. Despite decades research emphasizing role Aβ accumulation in AD pathogenesis, clinical trials targeting have obtained disappointing results, highlighting complexity pathophysiology need investigating other approaches. In this manuscript, we first discuss challenges associated anti-Aβ therapies, including efficacy potential adverse effects, underscoring necessity alternative mechanisms targets. Thereafter, promising non-Aβ-based strategies, such as tau-targeted neuroinflammation modulation, gene stem cell therapy. These approaches offer new avenues treatment by addressing additional pathological hallmarks downstream effects beyond deposition.
Language: Английский
Citations
5Peanut meal-derived bioactive compounds: Extraction, co-extrusion encapsulation and neuroprotection against aluminum-induced Alzheimer's disease via in silico and in vivo studies
Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(3), P. 100588 - 100588
Published: June 7, 2024
Peanut meal (seeds waste with the red skin) contains antioxidants and anti-inflammatory compounds, which protect cells from oxidative stress inflammation. Hypothesis: This byproduct can be used to produce nutraceutical functional food items that may become popular. Methods: Ultrasound-assisted extraction was prepare peanut extracts at various times different solvents of 90 % (acetone, ethanol, methanol, acetic acid ethyl ester). Acetone extracting (for 20 min ) demonstrated highest total phenolic content (83.78 mg GAE/g meal) DPPH scavenging activity (95.83 %). extract (PME) analyzed by HPLC encapsulated using sodium alginate via co-extrusion technique. The alginate/PME microbeads were studied for their morphology release compounds. Results: results molecular docking a strong binding affinity, implying identified compounds in PME inhibit acetylcholinesterase. Through vivo study, it revealed antioxidant effects AlCl3-treated rats. Additionally, reduced acetylcholinesterase while elevating levels dopamine serotonin compared Conclusion: work provided valuable contributions towards valorization byproducts, highlighting potential neuroprotective effect against aluminum-induced Alzheimer's disease.
Language: Английский
Citations
4New Sulfonate Ester‐Linked Fluorinated Hydrazone Derivatives as Multitarget Carbonic Anhydrase and Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, Molecular Docking and ADME Analysis
Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(12)
Published: Aug. 19, 2024
Abstract In this study, some new hydrazone derivatives ( 2a – g ) was designed, synthesized for first time, and evaluated as multitarget inhibitors of AChE, BChE, hCA I II. The chemical structures hybrids were confirmed by elemental analysis spectroscopic techniques. All tested compounds showed low nanomolar inhibition with IC 50 values in the range 30.4–264.0 nM against I, 23.2–251.6 II, 12.1–114.3 76.4–134.0 BChE. These inhibited AChE more than acetazolamide (AZA) neostigmine. Among them, 2c 2e , which have a linear structure, determined to be most active inhibitor candidates these selected enzymes. Molecular docking studies carried out on 2a‐ ‐ ), revealing their binding interactions site II thus supporting experimental findings. Additionally, silico absorption, distribution, metabolism, excretion (ADME) prediction obtained approaches determine solubility, whether they potential cross blood‐brain barrier (BBB), such GI absorption drug likeness principles.
Language: Английский
Citations
4Factors Affecting Pathological Amyloid Protein Transformation: From Post-Translational Modifications to Chaperones
Biochemistry (Moscow), Journal Year: 2025, Volume and Issue: 90(S1), P. S164 - S192
Published: Feb. 1, 2025
Language: Английский
Citations
0Recent advances in therapeutic strategies for Alzheimer's and Parkinson's disease using protein/peptide co‐modified polymer nanoparticles
Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 28, 2024
Abstract The blood‐brain barrier (BBB), which protects the brain from foreign molecules, makes delivery of drugs to central nervous system is challenging. Nanoparticles (NPs) have been used over past decade as drug systems for treatment many disorders with great results. However, effectiveness NPs in delivering Alzheimer's disease (AD) and Parkinson's (PD) limited by BBB. A recent breakthrough nanotechnology involves use surface‐modified polymer that enhance absorption transport across BBB; however, technology still has some limitations. Studies conducted few years demonstrated modified peptides or proteins can effectively cross BBB via specific receptors, thus enhancing their efficiency. In this review, we explore combined AD PD. This discussion focuses on pathophysiology these diseases, BBB, potential therapeutics based co‐modifying proteins. Additionally, outline future directions conjugated biomolecules.
Language: Английский
Citations
3Neuroprotective Effects of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) against Amyloid-β-Induced Alzheimer’s Disease Mouse Model
Nutrients, Journal Year: 2023, Volume and Issue: 15(23), P. 4986 - 4986
Published: Dec. 1, 2023
Alzheimer’s disease (AD), is a progressive neurodegenerative disorder that involves the deposition of β-amyloid plaques and clinical symptoms confusion, memory loss, cognitive dysfunction. Despite enormous progress in field, no curative treatment available. Therefore, current study was designed to determine neuroprotective effects N-methyl-(2S, 4R)-Trans-4-hydroxy-L-proline (NMP) obtained from Sideroxylon obtusifolium, Brazilian folk medicine with anti-inflammatory anti-oxidative properties. Here, for first time, we explored role NMP Aβ1–42-injected mouse model AD. After acclimatization, single intracerebroventricular injection Aβ1–42 (5 µL/5 min/mouse) C57BL/6N mice induced significant amyloidogenesis, reactive gliosis, oxidative stress, neuroinflammation, synaptic deficits. However, an intraperitoneal at dose (50 mg/kg/day) three consecutive weeks remarkably decreased beta secretase1 (BACE-1) Aβ, activated astrocyte microglia expression level as well downstream inflammatory mediators such pNF-ĸB, TNF-α, IL-1β. NPM also strongly attenuated evaluated by NRF2/HO-1, failure, improving both presynaptic (SNAP-25 SYN) postsynaptic (PSD-95 SNAP-23) regions synapses cortexes hippocampi mice, contributing improvement AD behavioral deficits displayed Morris water maze Y-maze. Overall, our data suggest provides potent multifactorial effects, including inhibition amyloid plaques,
Language: Английский
Citations
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